No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake

European Journal of Clinical Nutrition

Volumn 66, Issue 12, 2012, Pages 1315-1322

  Frassetto, L A ^a   Hardcastle, A C ^b   Sebastian, A ^a   Aucott, L ^b   Fraser, W D ^c   Reid, D M ^a   MacDonald, H M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

blood pressure; diet; osteoporosis; potassium; sodium chloride

Indexed keywords

CALCIUM; CHLORIDE; CHROMIUM; CITRATE POTASSIUM; DEOXYPYRIDINOLINE; PHOSPHATE; PLACEBO; POTASSIUM; POTASSIUM BICARBONATE; SODIUM; SODIUM CHLORIDE;

ADULT; ARTICLE; BLOOD PRESSURE; BONE DENSITY; BONE TURNOVER; CHLORIDE EXCRETION; DATA ANALYSIS; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG DOSE COMPARISON; DRUG MEGADOSE; DUAL ENERGY X RAY ABSORPTIOMETRY; ELECTROLYTE EXCRETION; FEMALE; FRUIT; HIP; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; OSTEOLYSIS; PATIENT COMPLIANCE; POSTMENOPAUSE; PREDICTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; SODIUM EXCRETION; SODIUM INTAKE; SPINE; SYSTOLIC BLOOD PRESSURE; UNITED KINGDOM; UNITED STATES; URINALYSIS; VEGETABLE;

ADULT; AGED; AGED, 80 AND OVER; ALKALIES; BIOLOGICAL MARKERS; BLOOD PRESSURE; BONE DENSITY; BONE RESORPTION; CALIFORNIA; CHLORIDES; DIET; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POTASSIUM, DIETARY; RETROSPECTIVE STUDIES; SCOTLAND; SODIUM; SODIUM CHLORIDE, DIETARY; SPINE;

RATTUS;

EID: 84870798986     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2012.151     Document Type: Article

References (58)

1. Barrett-Connor E, Gore R, Browner WS, Cummings SR. Prevention of osteoporotic hip fracture: global versus high-risk strategies. Osteoporos Int 1998; 8: S2-S7.
2. Teucher B, Fairweather-Tait S. Dietary sodium as a risk factor for osteoporosis: where is the evidence? Proc Nutr Soc 2003; 62: 859-866.
3. Krieger NS, Frick KK, LaPlante Strutz K, Michalenka A, Bushinsky DA. Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro. J Bone Miner Res 2007; 22: 907-917.
4. Bushinsky DA, Lechleider RJ. Mechanism of proton-induced bone calcium release: calcium carbonate-dissolution. Am J Physiol 1987; 53(5 Pt 2): F998-1005.
5. Lutz J. Calcium balance and acid-base status of women as affected by increased protein intake and by sodium bicarbonate ingestion. Am J Clin Nutr 1984; 39: 281-288.
6. Lemann Jr J, Litzow JR, Lennon EJ. The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. J Clin Invest 1966; 45: 1608-1614.
7. Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris Jr RC. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994; 330: 1776-1781.
8. Batlle DC, Sharma AM, Alsheikha MW, Sobrero M, Saleh A, Gutterman C. Renal acid excretion and intracellular pH in salt-sensitive genetic hypertension. J Clin Invest 1993; 91: 2178-2184.
9. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008; 23: 517-524.
10. Fenton TR, Eliasziw M, Tough SC, Lyon AW, Brown JP, Hanley DA. Low urine pH and acid excretion do not predict bone fractures or the loss of bone mineral density: a prospective cohort study. BMC Musculoskelet Disord 2010; 11: 88-88.
11. Macdonald HM, Black AJ, Aucott L, Duthie G, Duthie S, Sandison R et al. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. Am J Clin Nutr 2008; 88: 465-474.
12. King Jr JS, Jackson R, Ashe B. Relation of sodium intake to urinary calcium excretion. Invest Urol 1964; 1: 555-560.
13. McCarron DA, Rankin LI, Bennett WM, Krutzik S, McClung MR, Luft FC. Urinary calcium excretion at extremes of sodium intake in normal man. Am J Nephrol 1981; 1: 84-90.
14. Heaney RP. Role of dietary sodium in osteoporosis. J Am Coll Nutr 2006; 25: 271S-276S.
15. Aub JC, Tibbetts DM, McLean R. The influence of parathyroid hormone, urea, sodium chloride, fat and intertinal activity on calcium balance. J Nutr 1937; 113: 635-655.
16. Lin PH, Ginty F, Appel LJ, Aickin M, Bohannon A, Garnero P et al. The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. J Nutr 2003; 133: 3130-3136.
17. Zemel MB, Bedford BA, Standley PR, Sowers JR. Saline infusion causes rapid increase in parathyroid hormone and intracellular calcium levels. Am J Hypertens 1989; 2: 185-187.
18. Frassetto LA, Morris Jr RC, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol 2007; 293: F521-F525.
19. Weinberger MH. Salt sensitivity of blood pressure in humans. Hypertension 1996; 27: 481-490.
20. Schmidlin O, Forman A, Leone A, Sebastian A, Morris Jr RC. Salt sensitivity in blacks: evidence that the initial pressor effect of NaCl involves inhibition of vasodilatation by asymmetrical dimethylarginine. Hypertension 2011; 58: 380-385.
21. Morris Jr RC, Sebastian A, Forman A, Tanaka M, Schmidlin O. Normotensive salt sensitivity: effects of race and dietary potassium. Hypertension 1999; 33: 18-23.
22. Houston MC. The importance of potassium in managing hypertension. Curr Hypertens Rep 2011; 13: 309-317.
23. Lin JS, O'Connor E, Whitlock EP, Beil TL. Behavioral counseling to promote physical activity and a healthful diet to prevent cardiovascular disease in adults: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 2010; 153: 736-750.
24. Persy V, D'Haese P. Vascular calcification and bone disease: the calcification paradox. Trends Mol Med 2009; 15: 405-416.
25. D'Amelio P, Isaia G, Isaia GC. The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease. J Endocrinol Invest 2009; 32(4 Suppl): 6-9.
26. Schmidlin O, Leone A, Forman A, Sebastian A, Morris RC. Evidence that ADMAmediated vascular dysfunction can initiate salt sensitivity in normotensive African Americans. Hypertension 2008; 52: E128.
27. Fang Y, Mu JJ, He LC, Wang SC, Liu ZQ. Salt loading on plasma asymmetrical dimethylarginine and the protective role of potassium supplement in normotensive salt-sensitive asians. Hypertension 2006; 48: 724-729.
28. Sharma AM, Kribben A, Schattenfroh S, Cetto C, Distler A. Salt sensitivity in humans is associated with abnormal acid-base regulation. Hypertension 1990; 16: 407-413.
29. Frassetto LA, Schmidlin O, Sebastian A. Sodium chloride sensitivity: a dual attack on blood pressure and bone. J Am Soc Nephrol 2009; 20: 759A.
30. Wimalawansa SJ. Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans. Ann NY Acad Sci 2007; 1117: 283-297.
31. Nabhan AF, Rabie NH. Isosorbide mononitrate versus alendronate for postmenopausal osteoporosis. Int J Gynaecol Obstet 2008; 103: 213-216.
32. Jamal SA, Goltzman D, Hanley DA, Papaioannou A, Prior JC, Josse RG. Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study. Osteoporos Int 2009; 20: 737-744.
33. Frassetto LA, Todd KM, Morris Jr RC, Sebastian A. Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. Am J Clin Nutr 1998; 68: 576-583.
34. Bingham SA, Gill C, Welch A, Cassidy A, Runswick SA, Oakes S et al. Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers. Intl J Epidemiol 1997; 26(Suppl 1): S137-S151.
35. Day N, McKeown N, Wong M, Welch A, Bingham S. Epidemiological assessment of diet: a comparison of a 7-day diary with a food frequency questionnaire using urinary markers of nitrogen, potassium and sodium. Intl J Epidemiol 2001; 30: 309-317.
36. McKeown NM, Day NE, Welch AA, Runswick SA, Luben RN, Mulligan AA et al. Use of biological markers to validate self-reported dietary intake in a random sample of the European prospective investigation into Cancer United Kingdom Norfolk Cohort. Am J Clin Nutr 2001; 74: 188-196.
37. MacDonald AG, Birkinshaw G, Durham B, Bucknall RC, Fraser WD. Biochemical markers of bone turnover in seronegative spondylarthropathy: relationship to disease activity. Br J Rheumatol 1997; 36: 50-53.
38. Macdonald HM, Hardcastle AC, Duthie GG, Duthie SJ, Aucott L, Sandison R et al. Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers. Br J Nutr 2009; 102: 1477-1486.
39. Frassetto L, Morris RCJ, Sebastian A. Long-term persistence of the urine calciumlowering effect of potassium bicarbonate in postmenopausal women. J Clin Endocrinol Metab 2005; 90: 831-834.
40. Cummings SR, Block G, McHenry K, Baron RB. Evaluation of two food frequency methods of measuring dietary calcium intake. Am J Epidemiol 1987; 126: 796-802.
41. Remer T, Manz F. Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. Am J Clin Nutr 1994; 59: 1356-1361.
42. Sellmeyer DE, Stone KL, Sebastian A, Cummings SR. A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr 2001; 73: 118-122.
43. Dawson-Hughes B, Harris SS, Palermo NJ, Castaneda-Sceppa C, Rasmussen HM, Dallal GE. Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women. J Clin Endocrinol Metab 2009; 94: 96-102.
44. J Jehle S, Zanetti A, Muser J, Hulter HN, Krapf R. Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia. J Am Soc Nephrol 2006; 17: 3213-3222.
45. Sellmeyer DE, Schloetter M, Sebastian A. Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab 2002; 87: 2008-2012.
46. Jehle S, Krapf R. Long term neutralization of diet-induced acid load by K citrate increases bone density in elderly subjects with normal bone mass: Results of a 2 year placebo controlled trial. J Am Soc Nephrol 2010; 21: 36 (F-FC2).
47. Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA. Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr 2009; 90: 1674-1692.
48. Fenton TR, Tough SC, Lyon AW, Eliasziw M, Hanley DA. Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality. Nutr J 2011; 10: 41.
49. Fenton TR, Lyon AW, Eliasziw M, Tough SC, Hanley DA. Meta-analysis of the effect of the acid-ash hypothesis of osteoporosis on calcium balance. J Bone Miner Res 2009; 24: 1835-1840.
50. Chen J. Sodium sensitivity of blood pressure in Chinese populations. Curr Hypertens Rep 2010; 12: 127-134.
51. von Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E. Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int 2007; 18: 1337-1344.
52. Li J, White J, Guo L, Zhao X, Wang J, Smart EJ et al. Salt inactivates endothelial nitric oxide synthase in endothelial cells. J Nutr 2009; 139: 447-451.
53. Kasten TP, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Misko TP et al. Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase. Proc Natl Acad Sci USA 1994; 91: 3569-3573.
54. Lowik CW, Nibbering PH, van de Ruit M, Papapoulos SE. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest 1994; 93: 1465-1472.
55. Krishna GG. Effect of potassium intake on blood pressure. J Am Soc Nephrol 1990; 1: 43-52.
56. Allender PS, Cutler JA, Follmann D, Cappuccio FP, Pryer J, Elliott P. Dietary calcium and blood pressure: a meta-analysis of randomized clinical trials. Ann Intern Med 1996; 124: 825-831.
57. Jurgens G, Graudal NA. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride. Cochrane Database Syst Rev 2003, (1): CD004022.
58. Garnero P. Biomarkers for osteoporosis management: utility in diagnosis, fracture risk prediction and therapy monitoring. Mol Diagn Ther 2008; 12: 157-170.