메뉴 건너뛰기




Volumn 21, Issue 126, 2012, Pages 313-320

Challenges in the diagnosis and treatment of pulmonary arterial hypertension

Author keywords

Combination therapy; Diagnostic algorithms; Pulmonary arterial hypertensionspecific therapy; Screening

Indexed keywords

AMBRISENTAN; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; ENDOTHELIN RECEPTOR ANTAGONIST; ILOPROST; IMATINIB; MACITENTAN; PLACEBO; PROSTACYCLIN; SILDENAFIL; TADALAFIL; TREPROSTINIL;

EID: 84870765606     PISSN: 09059180     EISSN: 16000617     Source Type: Journal    
DOI: 10.1183/09059180.00005412     Document Type: Review
Times cited : (62)

References (45)
  • 1
    • 0032578279 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Gaine SP, Rubin LJ. Primary pulmonary hypertension. Lancet 1998; 352: 719-725.
    • (1998) Lancet , vol.352 , pp. 719-725
    • Gaine, S.P.1    Rubin, L.J.2
  • 2
    • 70349634397 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
    • Galie' N, HoeperMM, HumbertM, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Respir J 2009; 34: 1219-1263.
    • (2009) Eur Respir J , vol.34 , pp. 1219-1263
    • Galie', N.1    Hoeper, M.M.2    Humbert, M.3
  • 3
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, Sitbon O, Chaouat A, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010; 122: 156-163.
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 4
    • 58449122578 scopus 로고    scopus 로고
    • Connective tissue diseaseassociated pulmonary arterial hypertension in the modern treatment era
    • Condliffe R, Kiely DG, Peacock AJ, et al. Connective tissue diseaseassociated pulmonary arterial hypertension in the modern treatment era. Am J Respir Crit Care Med 2009; 179: 151-157.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 151-157
    • Condliffe, R.1    Kiely, D.G.2    Peacock, A.J.3
  • 5
    • 84863519076 scopus 로고    scopus 로고
    • An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL registry
    • Benza RL, Miller DP, Barst RJ, et al. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL registry. Chest 2012; 142: 448-456.
    • (2012) Chest , vol.142 , pp. 448-456
    • Benza, R.L.1    Miller, D.P.2    Barst, R.J.3
  • 6
    • 54049091919 scopus 로고    scopus 로고
    • Uncertainties in the diagnosis and treatment of pulmonary arterial hypertension
    • Ghofrani HA, Wilkins MW, Rich S. Uncertainties in the diagnosis and treatment of pulmonary arterial hypertension. Circulation 2008; 118: 1195-1201.
    • (2008) Circulation , vol.118 , pp. 1195-1201
    • Ghofrani, H.A.1    Wilkins, M.W.2    Rich, S.3
  • 7
    • 78651415646 scopus 로고    scopus 로고
    • The changing picture of patients with pulmonary arterial hypertension in the United States: How REVEAL differs from historic and non-US Contemporary Registries
    • Frost AE, Badesch DB, Barst RJ, et al. The changing picture of patients with pulmonary arterial hypertension in the United States: how REVEAL differs from historic and non-US Contemporary Registries. Chest 2011; 139: 128-137.
    • (2011) Chest , vol.139 , pp. 128-137
    • Frost, A.E.1    Badesch, D.B.2    Barst, R.J.3
  • 8
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension. A national prospective study
    • Rich S, Dantzker DR, Ayres SM, et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216-223.
    • (1987) Ann Intern Med , vol.107 , pp. 216-223
    • Rich, S.1    Dantzker, D.R.2    Ayres, S.M.3
  • 9
    • 33646269035 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in France: Results from a national registry
    • Humbert M, Sitbon O, Chaouat A, et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 2006; 173: 1023-1030.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 1023-1030
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 10
    • 76749135710 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Baseline characteristics from the REVEAL Registry
    • Badesch DB, Raskob GE, Elliott CG, et al. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest 2010; 137: 376-387.
    • (2010) Chest , vol.137 , pp. 376-387
    • Badesch, D.B.1    Raskob, G.E.2    Elliott, C.G.3
  • 11
    • 79960103454 scopus 로고    scopus 로고
    • Delay in recognition of pulmonary arterial hypertension: Factors identified from the REVEAL Registry
    • Brown LM, Chen H, Halpern S, et al. Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry. Chest 2011; 140: 19-26.
    • (2011) Chest , vol.140 , pp. 19-26
    • Brown, L.M.1    Chen, H.2    Halpern, S.3
  • 12
    • 2942603006 scopus 로고    scopus 로고
    • Diagnosis and differential assessment of pulmonary arterial hypertension
    • Barst RJ, McGoon M, Torbicki A, et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: Suppl. 12, 40S-47S.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL. 12
    • Barst, R.J.1    McGoon, M.2    Torbicki, A.3
  • 13
    • 79953205584 scopus 로고    scopus 로고
    • REVEAL registry: Correlation of right heart catheterization and echocardiography in patients with pulmonary arterial hypertension
    • Farber HW, Foreman AJ, Miller DP, et al. REVEAL registry: correlation of right heart catheterization and echocardiography in patients with pulmonary arterial hypertension. Congest Heart Fail 2011; 17: 56-64.
    • (2011) Congest Heart Fail , vol.17 , pp. 56-64
    • Farber, H.W.1    Foreman, A.J.2    Miller, D.P.3
  • 14
    • 29144536869 scopus 로고    scopus 로고
    • Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study
    • Hachulla E, Gressin V, Guillevin L, et al. Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study. Arthritis Rheum 2005; 52: 3792-3800.
    • (2005) Arthritis Rheum , vol.52 , pp. 3792-3800
    • Hachulla, E.1    Gressin, V.2    Guillevin, L.3
  • 15
    • 78649813429 scopus 로고    scopus 로고
    • ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)
    • Baumgartner H, Bonhoeffer P, DeGroot N, et al. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). Eur Heart J 2010; 31: 2915-2957.
    • (2010) Eur Heart J , vol.31 , pp. 2915-2957
    • Baumgartner, H.1    Bonhoeffer, P.2    DeGroot, N.3
  • 16
    • 55549116023 scopus 로고    scopus 로고
    • Role of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension
    • Benza R, Biederman R, Murali S, et al. Role of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension. J Am Coll Cardiol 2008; 52: 1683-1692.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1683-1692
    • Benza, R.1    Biederman, R.2    Murali, S.3
  • 17
    • 69249109309 scopus 로고    scopus 로고
    • Cardiac magnetic resonance imaging for the assessment of the heart and pulmonary circulation in pulmonary hypertension
    • McLure LE, Peacock AJ. Cardiac magnetic resonance imaging for the assessment of the heart and pulmonary circulation in pulmonary hypertension. Eur Respir J 2009; 33: 1454-1466.
    • (2009) Eur Respir J , vol.33 , pp. 1454-1466
    • McLure, L.E.1    Peacock, A.J.2
  • 18
    • 33845343982 scopus 로고    scopus 로고
    • Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers
    • Hoeper MM, Lee SH, Voswinckel R, et al. Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers. J Am Coll Cardiol 2006; 48: 2546-2552.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 2546-2552
    • Hoeper, M.M.1    Lee, S.H.2    Voswinckel, R.3
  • 19
    • 67650828330 scopus 로고    scopus 로고
    • Misclassification of pulmonary hypertension due to reliance on pulmonary capillary wedge pressure rather than left ventricular end-diastolic pressure
    • Halpern SD, Taichman DB. Misclassification of pulmonary hypertension due to reliance on pulmonary capillary wedge pressure rather than left ventricular end-diastolic pressure. Chest 2009; 136: 37-43.
    • (2009) Chest , vol.136 , pp. 37-43
    • Halpern, S.D.1    Taichman, D.B.2
  • 20
    • 62549141018 scopus 로고    scopus 로고
    • Pulmonary hypertension in heart failure with preserved ejection fraction: A communitybased study
    • Lam CS, Roger VL, Rodeheffer RJ, et al. Pulmonary hypertension in heart failure with preserved ejection fraction: a communitybased study. J Am Coll Cardiol 2009; 53: 1119-1126.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1119-1126
    • Lam, C.S.1    Roger, V.L.2    Rodeheffer, R.J.3
  • 21
    • 84855471916 scopus 로고    scopus 로고
    • Combined pulmonary fibrosis and emphysema syndrome: A review
    • Jankowich MD, Rounds SI. Combined pulmonary fibrosis and emphysema syndrome: a review. Chest 2012; 141: 222-231.
    • (2012) Chest , vol.141 , pp. 222-231
    • Jankowich, M.D.1    Rounds, S.I.2
  • 22
    • 84875833523 scopus 로고    scopus 로고
    • National Health Service Information Centre, Date last accessed: June 12, 2012
    • National Health Service Information Centre. National audit of pulmonary hypertension 2011. www.ic.nhs.uk/services/nationalclinical-audit-support-programme-ncasp/audit-reports/heart-disease Date last accessed: June 12, 2012.
    • (2011) National audit of pulmonary hypertension
  • 23
    • 45249119855 scopus 로고    scopus 로고
    • Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): A double-blind, randomised controlled trial
    • Galie' N, Rubin LJ, Hoeper M, et al. Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 2008; 371: 2093-2100.
    • (2008) Lancet , vol.371 , pp. 2093-2100
    • Galie', N.1    Rubin, L.J.2    Hoeper, M.3
  • 24
    • 0037331116 scopus 로고    scopus 로고
    • Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis
    • Kawut SM, Taichman DB, Archer-Chicko CL, et al. Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis. Chest 2003; 123: 344-350.
    • (2003) Chest , vol.123 , pp. 344-350
    • Kawut, S.M.1    Taichman, D.B.2    Archer-Chicko, C.L.3
  • 25
    • 84855358253 scopus 로고    scopus 로고
    • The pulmonary arterial hypertension quality enhancement research initiative: Comparison of patients with idiopathic PAH to patients with systemic sclerosis-associated PAH
    • Clements PJ, Tan M, McLaughlin VV, et al. The pulmonary arterial hypertension quality enhancement research initiative: comparison of patients with idiopathic PAH to patients with systemic sclerosis-associated PAH. Ann Rheum Dis 2012; 71: 249-252.
    • (2012) Ann Rheum Dis , vol.71 , pp. 249-252
    • Clements, P.J.1    Tan, M.2    McLaughlin, V.V.3
  • 26
    • 78650319609 scopus 로고    scopus 로고
    • Treat-to-target strategies in pulmonary arterial hypertension: The importance of using multiple goals
    • Sitbon O, Galie' N. Treat-to-target strategies in pulmonary arterial hypertension: the importance of using multiple goals. Eur Respir Rev 2010; 19: 272-278.
    • (2010) Eur Respir Rev , vol.19 , pp. 272-278
    • Sitbon, O.1    Galie', N.2
  • 27
    • 27744504402 scopus 로고    scopus 로고
    • Goal-orientated treatment and combination therapy for pulmonary arterial hypertension
    • Hoeper M, Markevych I, Spiekerkoetter E, et al. Goal-orientated treatment and combination therapy for pulmonary arterial hypertension. Eur Respir J 2005; 26: 858-863.
    • (2005) Eur Respir J , vol.26 , pp. 858-863
    • Hoeper, M.1    Markevych, I.2    Spiekerkoetter, E.3
  • 28
    • 84857874027 scopus 로고    scopus 로고
    • How to detect disease progression in pulmonary arterial hypertension
    • Vachiéry JL, Yerly P, Huez S. How to detect disease progression in pulmonary arterial hypertension. Eur Respir Rev 2012; 21: 40-47.
    • (2012) Eur Respir Rev , vol.21 , pp. 40-47
    • Vachiéry, J.L.1    Yerly, P.2    Huez, S.3
  • 29
    • 84857856069 scopus 로고    scopus 로고
    • The prognostic impact of follow-up assessments in patients with idiopathic pulmonary arterial hypertension
    • Nickel N, Golpon H, Greer M, et al. The prognostic impact of follow-up assessments in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 2012; 39: 589-596.
    • (2012) Eur Respir J , vol.39 , pp. 589-596
    • Nickel, N.1    Golpon, H.2    Greer, M.3
  • 30
    • 4544383466 scopus 로고    scopus 로고
    • Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
    • Humbert M, Barst RJ, Robbins IM, et al. Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J 2004; 24: 353-359.
    • (2004) Eur Respir J , vol.24 , pp. 353-359
    • Humbert, M.1    Barst, R.J.2    Robbins, I.M.3
  • 31
    • 33845526777 scopus 로고    scopus 로고
    • Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
    • McLaughlin VV, Oudiz RJ, Frost A, et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med 2006; 174: 1257-1263.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1257-1263
    • McLaughlin, V.V.1    Oudiz, R.J.2    Frost, A.3
  • 32
    • 10444246635 scopus 로고    scopus 로고
    • Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension
    • Hoeper MM, Faulenbach C, Golpon H, et al. Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension. Eur Respir J 2004; 24: 1007-1010.
    • (2004) Eur Respir J , vol.24 , pp. 1007-1010
    • Hoeper, M.M.1    Faulenbach, C.2    Golpon, H.3
  • 33
    • 54549125950 scopus 로고    scopus 로고
    • Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: A randomized trial
    • Simonneau G, Rubin LJ, Galie' N, et al. Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial. Ann Intern Med 2008; 149: 521-530.
    • (2008) Ann Intern Med , vol.149 , pp. 521-530
    • Simonneau, G.1    Rubin, L.J.2    Galie', N.3
  • 34
    • 77952301237 scopus 로고    scopus 로고
    • Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: A randomized controlled clinical trial
    • McLaughlin VV, Benza RL, Rubin LJ, et al. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. J Am Coll Cardiol 2010; 55: 1915-1922.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1915-1922
    • McLaughlin, V.V.1    Benza, R.L.2    Rubin, L.J.3
  • 35
    • 84866515810 scopus 로고    scopus 로고
    • Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (The FREEDOM-C Study): A randomized controlled trial
    • [Epub ahead of print DOI: 10.1378/chest.11-2212]
    • Tapson V, Torres F, Kermeen F, et al. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (The FREEDOM-C Study): a randomized controlled trial. Chest 2012; [Epub ahead of print DOI: 10.1378/chest.11-2212].
    • (2012) Chest
    • Tapson, V.1    Torres, F.2    Kermeen, F.3
  • 36
    • 84858809665 scopus 로고    scopus 로고
    • Imatinib improves exercise capacity and hemodynamics at 24 weeks as add-on therapy in symptomatic pulmonary arterial hypertension patients: The IMPRES Study
    • Hoeper M, Barst R, Bourge R, et al. Imatinib improves exercise capacity and hemodynamics at 24 weeks as add-on therapy in symptomatic pulmonary arterial hypertension patients: the IMPRES Study. Chest 2011; 140: 1045A.
    • (2011) Chest , vol.140
    • Hoeper, M.1    Barst, R.2    Bourge, R.3
  • 37
    • 67649523052 scopus 로고    scopus 로고
    • Tadalafil therapy for pulmonary arterial hypertension
    • Galie' N, Brundage B, Ghofrani HA, et al. Tadalafil therapy for pulmonary arterial hypertension. Circulation 2009; 119: 2894-2903.
    • (2009) Circulation , vol.119 , pp. 2894-2903
    • Galie', N.1    Brundage, B.2    Ghofrani, H.A.3
  • 38
    • 77951054360 scopus 로고    scopus 로고
    • Endpoints in pulmonary arterial hypertension: The role of clinical worsening
    • Peacock A, Keogh A, Humbert M. Endpoints in pulmonary arterial hypertension: the role of clinical worsening. Curr Opin Pulm Med 2010; 16: Suppl. 1, S1-S9.
    • (2010) Curr Opin Pulm Med , vol.16 , Issue.SUPPL. 1
    • Peacock, A.1    Keogh, A.2    Humbert, M.3
  • 39
    • 77951045619 scopus 로고    scopus 로고
    • Perspective on the optimal endpoints for pulmonary arterial hypertension trials
    • Rubin L, Simonneau G. Perspective on the optimal endpoints for pulmonary arterial hypertension trials. Curr Opin Pulm Med 2010; 16: Suppl. 1, S43-S46.
    • (2010) Curr Opin Pulm Med , vol.16 , Issue.SUPPL. 1
    • Rubin, L.1    Simonneau, G.2
  • 40
    • 73449084124 scopus 로고    scopus 로고
    • Long-term outcome in pulmonary arterial hypertension: A plea for earlier parenteral prostacyclin therapy
    • Delcroix M, Spaas K, Quarck R. Long-term outcome in pulmonary arterial hypertension: a plea for earlier parenteral prostacyclin therapy. Eur Respir Rev 2009; 18: 253-259.
    • (2009) Eur Respir Rev , vol.18 , pp. 253-259
    • Delcroix, M.1    Spaas, K.2    Quarck, R.3
  • 41
    • 79959718398 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension and lung transplantation
    • Lordan JL, Corris PA. Pulmonary arterial hypertension and lung transplantation. Expert Rev Respir Med 2011; 5: 441-454.
    • (2011) Expert Rev Respir Med , vol.5 , pp. 441-454
    • Lordan, J.L.1    Corris, P.A.2
  • 42
    • 84960198380 scopus 로고    scopus 로고
    • Atrial septostomy
    • In: Humbert M, Souza R, Simonneau G, eds, Basel, Karger
    • Vachiéry JL. Atrial septostomy. In: Humbert M, Souza R, Simonneau G, eds. Pulmonary Vascular Disorders. Volume 41. Basel, Karger, 2012; pp. 1-8.
    • (2012) Pulmonary Vascular Disorders , vol.41 , pp. 1-8
    • Vachiéry, J.L.1
  • 43
    • 79959744503 scopus 로고    scopus 로고
    • Atrial septostomy in patients with pulmonary hypertension: Should it be recommended
    • Lammers AE, Haworth SG, Diller GP. Atrial septostomy in patients with pulmonary hypertension: should it be recommended? Expert Rev Respir Med 2011; 5: 363-376.
    • (2011) Expert Rev Respir Med , vol.5 , pp. 363-376
    • Lammers, A.E.1    Haworth, S.G.2    Diller, G.P.3
  • 44
    • 67649589485 scopus 로고    scopus 로고
    • Interventional and surgical modalities of treatment in pulmonary hypertension
    • Keogh AM, Mayer E, Benza RL, et al. Interventional and surgical modalities of treatment in pulmonary hypertension. J Am Coll Cardiol 2009; 54: Suppl. 1, S67-S77.
    • (2009) J Am Coll Cardiol , vol.54 , Issue.SUPPL. 1
    • Keogh, A.M.1    Mayer, E.2    Benza, R.L.3
  • 45
    • 82555189244 scopus 로고    scopus 로고
    • Effect of atrial septostomy on the survival of patients with severe pulmonary arterial hypertension
    • Sandoval J, Gaspar J, Peña H, et al. Effect of atrial septostomy on the survival of patients with severe pulmonary arterial hypertension. Eur Respir J 2011; 38: 1343-1348.
    • (2011) Eur Respir J , vol.38 , pp. 1343-1348
    • Sandoval, J.1    Gaspar, J.2    Peña, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.