Pulmonary arterial hypertension and lung transplantation

Expert Review of Respiratory Medicine

Volumn 5, Issue 3, 2011, Pages 441-454

  Lordan, James L ^a   Corris, Paul A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

atrial septostomy; bridge to transplantation; lung allocation scores; lung transplantation; Novalung lung assist device; prognosis; pulmonary arterial hypertension; transplantation outcomes

Indexed keywords

ALEMTUZUMAB; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANTINEOPLASTIC AGENT; AZATHIOPRINE; AZITHROMYCIN; BASILIXIMAB; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN; CYTOMEGALOVIRUS ANTIBODY; GANCICLOVIR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RITUXIMAB; TACROLIMUS; THYMOCYTE ANTIBODY; VALGANCICLOVIR;

ACUTE GRAFT REJECTION; ARTIFICIAL LUNG; BACTERIAL INFECTION; CHRONIC GRAFT REJECTION; CHRONIC KIDNEY DYSFUNCTION; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; COMORBIDITY; CONGENITAL HEART DISEASE; CONNECTIVE TISSUE DISEASE; CYTOMEGALOVIRUS INFECTION; DIABETES MELLITUS; DISEASE ASSOCIATION; DOUBLE LUNG TRANSPLANTATION; DRUG DOSE REDUCTION; DRUG INDUCED CANCER; ENDARTERECTOMY; EXTRACORPOREAL OXYGENATION; GRAFT RECIPIENT; HEART ATRIAL SEPTOSTOMY; HEART LUNG TRANSPLANTATION; HEART SURGERY; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; KIDNEY DYSFUNCTION; KIDNEY FAILURE; LOW DRUG DOSE; LUNG GRAFT REJECTION; LUNG HEMODYNAMICS; LUNG TRANSPLANTATION; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MORBIDITY; MYCOSIS; ORGAN DONOR; OSTEOPOROSIS; PATIENT REFERRAL; PATIENT SELECTION; POSTOPERATIVE PERIOD; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; PRACTICE GUIDELINE; PRIMARY GRAFT DYSFUNCTION; PROGNOSIS; PULMONARY HYPERTENSION; PULMONARY VENO-OCCLUSIVE DISEASE; REVIEW; RISK FACTOR; SCORING SYSTEM; SKIN CANCER; SURGICAL TECHNIQUE; SURVIVAL; TREATMENT INDICATION; TREATMENT OUTCOME; VIRUS INFECTION;

EID: 79959718398     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.11.21     Document Type: Review

References (81)

1. Humbert M, Morrell NW, Archer SL et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43(12 Suppl. S), 13S-24S (2004 (Pubitemid 38759713)
2. McLaughlin VV, McGoon MD. Pulmonary arterial hypertension. Circulation 114(13), 1417-1431 (2006 (Pubitemid 44454562)
3. D'Alonzo GE, Barst RJ, Ayres SM et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann. Intern. Med. 115(5), 343-349 (1991
4. Simonneau G, Robbins IM, Beghetti M et al. Updated clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 54(Suppl. 1), S43-S54 (2009
5. Sitbon O, Humbert M, Nunes H et al. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J. Am. Coll. Cardiol. 40(4), 780-788 (2002 (Pubitemid 34925627)
6. McLaughlin VV, Shillington A, Rich S Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 106(12), 1477-1482 (2002
7. Rubin LJ, Badesch DB, Barst RJ et al. Bosentan therapy for pulmonary arterial hypertension. N. Engl. J. Med. 346(12), 896-903 (2002 (Pubitemid 34984638)
8. Provencher S, Sitbon O, Humbert M, Cabrol S, Jaïs X, Simonneau G. Long-term outcome with first-line bosentan therapy in idiopathic pulmonary arterial hypertension. Eur. Heart J. 27(5), 589-595 (2006
9. Galie N, Ghofrani HA, Torbicki A et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N. Engl. J. Med. 353(20), 2148-2157 (2005 (Pubitemid 41653106)
10. Galie N, Rubin LJ, Hoeper M et al. Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study), a double-blind, randomised controlled trial. Lancet 371(9630), 2093-2100 (2008 (Pubitemid 351902178)
11. Simonneau G, Rubin LJ, Galiè N et al. Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial. Ann. Intern. Med. 149(8), 521-525 (2005
12. Benza RL, Park MH, Keogh A, Girgis RE. Management of pulmonary arterial hypertension with a focus on combination therapies. J. Heart Lung Transplant. 26(5), 437-446 (2007 (Pubitemid 46602007)
13. Barst RJ, Gibbs JS, Ghofrani HA et al. Updated evidence-based treatment algorithm in pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54(Suppl. 1), S78-S84 (2009
14. Galie N, Hoeper MM, Humbert M et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur. Respir. J. 34(6), 1219-1263 (2009
15. Hoeper MM, Markevych I, Spiekerkoetter E, Welte T, Niedermeyer J. Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. Eur. Respir. J. 26(5), 858-863 (2005 (Pubitemid 41632043)
16. Humbert M, Sitbon O, Chaouat A et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 122(2), 156-163 (2010
17. Galie N, Manes A, Negro L, Palazzini M, Bacchi-Reggiani ML, Branzi A. A meta-analysis of randomized controlled trials in pulmonary arterial hypertension. Eur. Heart J. 30(4), 394-403 (2009
18. Benza RL, Miller DP, Gomberg-Maitland M et al. Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEALCirculation 122(2), 164-172 (2010
19. Thenappan T, Shah SJ, Rich S, Tian L, Archer SL, Gomberg-Maitland M. Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation. Eur. Respir. J. 35(5), 1079-1087 (2009
20. Christie JD, Edwards LB, Aurora P et al. The Registry of the International Society for Heart and Lung Transplantation: Twenty-Sixth Official Adult Lung And Heart-Lung Transplantation Report. J. Heart Lung Transplant. 28(10), 1031-1049 (2009
21. Miyamoto S, Nagaya N, Satoh T et al. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. Am. J. Respir. Crit. Care Med. 161(2 Pt 1), 487-492 (2000). (Pubitemid 30129457)
22. Wensel R, Opitz CF, Anker SD et al. Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing. Circulation 106(3), 319-324 (2002 (Pubitemid 34778955)
23. Forfia PR, Fisher MR, Mathai SC et al. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am. J. Respir. Crit. Care Med. 174(9), 1034-1041 (2006 (Pubitemid 44684453)
24. Kreider M, Kotloff RM. Selection of candidates for lung transplantation. Proc. Am. Thorac. Soc. 6(1), 20-27 (2009
25. Fijalkowska A, Kurzyna M, Torbicki A et al. Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension. Chest 129(5), 1313-1321 (2006
26. Orens JB, Estenne M, Arcasoy S et al. International guidelines for the selection of lung transplant candidates: 2006 update - a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. J. Heart Lung Transplant. 25(7), 745-755 (2006
27. Dandel M, Lehmkuhl HB, Mulahasanovic S et al. Survival of patients with idiopathic pulmonary arterial hypertension after listing for transplantation: impact of iloprost and bosentan treatment. J. Heart Lung Transplant. 26(9), 898-906 (2007 (Pubitemid 47369210)
28. Egan TM, Murray S, Bustami RT et al. Development of the new lung allocation system in the United States. Am. J. Transplant. 6(5 Pt 2), 1212-1227 (2006
29. Davis SQ, Garrity ER Jr. Organ allocation in lung transplant. Chest 132(5), 1646-1651 (2007 (Pubitemid 350156024)
30. Chan KM. Idiopathic pulmonary arterial hypertension and equity of donor lung allocation in the era of the lung allocation score: are we there yet? Am. J. Respir. Crit. Care Med. 180(5), 385-387 (2009
31. Chen H, Shiboski SC, Golden JA et al. Impact of the lung allocation score on lung transplantation for pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 180(5), 468-474 (2009
32. Hopkins WE, Ochoa LL, Richardson GW, Trulock EP. Comparison of the hemodynamics and survival of adults with severe primary pulmonary hypertension or Eisenmenger syndrome. J. Heart Lung Transplant. 15(1 Pt 1), 100-105 (1996 (Pubitemid 26056129)
33. Charman SC, Sharples LD, McNeil KD, Wallwork J. Assessment of survival benefit after lung transplantation by patient diagnosis. J. Heart Lung Transplant. 21(2), 226-232 (2002 (Pubitemid 34130540)
34. Corris PA. Atrial septostomy and transplantation for patients with pulmonary arterial hypertension. Semin. Respir. Crit. Care Med. 30(4), 493-501 (2009
35. Goerler H, Simon A, Gohrbandt B et al. Heart-lung and lung transplantation in grown-up congenital heart disease: long-term single centre experience. Eur. J. Cardiothorac. Surg. 32(6), 926-931 (2007 (Pubitemid 350081015)
36. Hosseinpour AR, Cullen S, Tsang VT. Transplantation for adults with congenital heart disease. Eur. J. Cardiothorac. Surg. 30(3), 508-514 (2006 (Pubitemid 44209327)
37. Smits JM, Vanhaecke J, Haverich A et al. Waiting for a thoracic transplant in Eurotransplant. Transpl. Int. 19(1), 54-66 (2006
38. McNeil K, Dunning J. Chronic thromboembolic pulmonary hypertension (CTEPHHeart 93(9), 1152-1158 (2007 (Pubitemid 47311004)
39. Cabrol S, Souza R, Jais X et al. Intravenous epoprostenol in inoperable chronic thromboembolic pulmonary hypertension. J. Heart Lung Transplant. 26(4), 357-362 (2007 (Pubitemid 46522504)
40. Johnson SR, Swiston JR, Granton JT. Prognostic factors for survival in scleroderma associated pulmonary arterial hypertension. J. Rheumatol. 35(8), 1584-1590 (2008
41. Shitrit D, Amital A, Peled N et al. Lung transplantation in patients with scleroderma: case series, review of the literature, and criteria for transplantation. Clin. Transplant 23(2), 178-183 (2009
42. Schachna L, Medsger TA Jr, Dauber JH et al. Lung transplantation in scleroderma compared with idiopathic pulmonary fibrosis and idiopathic pulmonary arterial hypertension. Arthritis Rheum. 54(12), 3954-3961 (2006 (Pubitemid 44955899)
43. Mertens V, Blondeau K, Van Oudenhove L et al. Bile acids aspiration reduces survival in lung transplant recipients with BOS despite azithromycin. Am. J. Transplant. 11(2), 329-335 (2011
44. Robertson AG, Ward C, Pearson JP, Corris PA, Dark JH, Griffin SM. Lung transplantation, gastroesophageal reflux, and fundoplication. Ann. Thorac. Surg. 89(2), 653-660 (2010
45. D'Ovidio F, Singer LG, Hadjiliadis D et al. Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann. Thorac. Surg. 80(4), 1254-1260 (2005 (Pubitemid 41354098)
46. Gutierrez C, Al-Faifi S, Chaparro C et al. The effect of recipient's age on lung transplant outcome. Am. J. Transplant. 7(5), 1271-1277 (2007 (Pubitemid 46643087)
47. Kanasky WF Jr, Anton SD, Rodrigue JR, Perri MG, Szwed T, Baz MA. Impact of body weight on long-term survival after lung transplantation. Chest 121(2), 401-406 (2002 (Pubitemid 34132975)
48. Hadjiliadis D, Chaparro C, Reinsmoen NL et al. Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study. J. Heart Lung Transplant. 24(Suppl. 7), S249-S254 (2005 (Pubitemid 40922657)
49. Levine SM, Jenkinson SG, Bryan CL et al. Ventilation-perfusion inequalities during graft rejection in patients undergoing single lung transplantation for primary pulmonary hypertension. Chest 101(2), 401-405 (1992
50. Bando K, Armitage JM, Paradis IL et al. Indications for and results of single, bilateral, and heart-lung transplantation for pulmonary hypertension. J. Thorac. Cardiovasc. Surg. 108(6), 1056-1065 (1994 (Pubitemid 24379859)
51. Waddell TK, Bennett L, Kennedy R, Todd TR, Keshavjee SH. Heart-lung or lung transplantation for Eisenmenger syndrome. J. Heart Lung Transplant. 21(7), 731-737 (2002 (Pubitemid 34718178)
52. Fadel E, Mercier O, Mussot S et al. Long-term outcome of double-lung and heart-lung transplantation for pulmonary hypertension: a comparative retrospective study of 219 patients. Eur. J. Cardiothorac. Surg. 38(3), 277-284 (2008
53. Toyoda Y, Thacker J, Santos R et al. Long-term outcome of lung and heart-lung transplantation for idiopathic pulmonary arterial hypertension. Ann. Thorac. Surg. 86(4), 1116-1122 (2008
54. Rich S, Lam W. Atrial septostomy as palliative therapy for refractory primary pulmonary hypertension. Am. J. Cardiol. 51(9), 1560-1561 (1983 (Pubitemid 13086714)
55. Hopkins WE. The remarkable right ventricle of patients with Eisenmenger syndrome. Coron. Artery Dis. 16(1), 19-25 (2005 (Pubitemid 40279593)
56. Cantu E, Duane Davis R Jr. Surgical Treatment of pulmonary hypertension. Adv. Pulmon. Hyperten. 9(1), 31-39 (2010
57. Sandoval J, Rothman A, Pulido T. Atrial septostomy for pulmonary hypertension. Clin. Chest Med. 22(3), 547-560 (2001). (Pubitemid 32912086)
58. Nihill MR, O'Laughlin MP, Mullins CE. Effects of atrial septostomy in patients with terminal cor pulmonale due to pulmonary vascular disease. Cathet. Cardiovasc. Diagn. 24(3), 166-172 (1991
59. Rothman A, Sklansky MS, Lucas VW et al. Atrial septostomy as a bridge to lung transplantation in patients with severe pulmonary hypertension. Am. J. Cardiol. 84(6), 682-686 (1999 (Pubitemid 29417961)
60. Sager JS, Ahya VN. Surgical therapies for pulmonary arterial hypertension. Clin. Chest Med. 28(1), 187-202, ix (2007 (Pubitemid 46335932)
61. Klepetko W, Mayer E, Benza RL et al. Interventional and surgical modalities of treatment for pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43(12 Suppl. S), 73S-80S (2004 (Pubitemid 38759721)
62. Althoff TF, Knebel F, Panda A et al. Long-term follow-up of a fenestrated Amplatzer atrial septal occluder in pulmonary arterial hypertension. Chest 133(1), 283-285 (2008
63. Gregoric ID, Chandra D, Myers TJ, Scheinin SA, Loyalka P, Kar B. Extracorporeal membrane oxygenation as a bridge to emergency heart-lung transplantation in a patient with idiopathic pulmonary arterial hypertension. J. Heart Lung Transplant. 27(4), 466-468 (2008 (Pubitemid 351418252)
64. Strueber M. Extracorporeal support as a bridge to lung transplantation. Curr. Opin. Crit. Care 16(1), 69-73 (2010
65. Strueber M, Hoeper MM, Fischer S et al. Bridge to thoracic organ transplantation in patients with pulmonary arterial hypertension using a pumpless lung assist device. Am. J. Transplant. 9(4), 853-857 (2009
66. Fischer S, Bohn D, Rycus P et al. Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registry. J. Heart Lung Transplant. 26(5), 472-477 (2007 (Pubitemid 46602004)
67. Taylor K, Holtby H. Emergency interventional lung assist for pulmonary hypertension. Anesth. Analg. 109(2), 382-385 (2009
68. van Loenhout KC, Groves SC, Galazka M et al. Early outcomes using alemtuzumab induction in lung transplantation. Interact. Cardiovasc. Thorac. Surg. 10(2), 190-194 (2009
69. Penketh AR, Higenbottam TW, Hutter J, Coutts C, Stewart S, Wallwork J. Clinical experience in the management of pulmonary opportunist infection and rejection in recipients of heart-lung transplants. Thorax 43(10), 762-769 (1988 (Pubitemid 18265577)
70. Glanville AR. Bronchoscopic monitoring after lung transplantation. Semin. Respir. Crit. Care Med. 31(2), 208-221 (2010
71. Kuntz CL, Hadjiliadis D, Ahya VN et al. Risk factors for early primary graft dysfunction after lung transplantation: a registry study. Clin. Transplant 23(6), 819-830 (2009
72. Lee JC, Christie JD, Primary graft dysfunction. Proc. Am. Thorac. Soc. 6(1), 39-46 (2009
73. Amital A, Shitrit D, Raviv Y et al. Surfactant as salvage therapy in life threatening primary graft dysfunction in lung transplantation. Eur. J. Cardiothorac. Surg. 35(2), 299-303 (2009
74. Wigfield CH, Lindsey JD, Steffens TG, Edwards NM, Love RB. Early institution of extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation improves outcome. J. Heart Lung Transplant. 26(4), 331-338 (2007 (Pubitemid 46498762)
75. Lyu DM, Zamora MR. Medical complications of lung transplantation. Proc. Am. Thorac. Soc. 6(1), 101-107 (2009
76. Mitsani D, Nguyen MH, Kwak EJ et al. Cytomegalovirus disease among donor-positive/recipient-negative lung transplant recipients in the era of valganciclovir prophylaxis. J. Heart Lung Transplant. 29(9), 1014-1020 (2010
77. Cooper JD, Billingham M, Egan T et al. A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation. J. Heart Lung Transplant. 12(5), 713-716 (1993 (Pubitemid 23305066)
78. Yates B, Murphy DM, Forrest IA et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. Am. J. Respir. Crit. Care Med. 172(6), 772-775 (2005 (Pubitemid 41324235)
79. Fisher AJ, Rutherford RM, Bozzino J, Parry G, Dark JH, Corris PA. The safety and efficacy of total lymphoid irradiation in progressive bronchiolitis obliterans syndrome after lung transplantation. Am. J. Transplant. 5(3), 537-543 (2005 (Pubitemid 40313345)
80. Reams BD, McAdams HP, Howell DN, Steele MP, Davis RD, Palmer SM. Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. Chest 124(4), 1242-1249 (2003 (Pubitemid 37290032)
81. Wudhikarn K, Holman CJ, Linan M et al. Post-transplant lymphoproliferative disorders in lung transplant recipients: 20-yr experience at the University of Minnesota. Clin. Transplant. DOI: 10.1111/j.1399-0012.2010. 01332.x (2010) (Epub ahead of print).