Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 235-242

  Yaziji, Vicente ^a,b   Rodríguez, David ^b   Coelho, Alberto ^a,b   García Mera, Xerardo ^b   El Maatougui, Abdelaziz ^a,b   Brea, José ^b   Loza, María Isabel ^b   Cadavid, María Isabel ^b   Gutiérrez De Terán, Hugo ^b   Sotelo, Eddy ^a,b  

^a s n   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

3D QSAR; Adenosine antagonists; Adenosine receptor; Grid Independent Descriptors (GRIND 2); Library synthesis; Pyrimidines; Suzuki Miyaura cross coupling reaction

Indexed keywords

1,2,4 TRIAZINE DERIVATIVE; ACETAMIDE; ADENOSINE A3 RECEPTOR ANTAGONIST; BORONIC ACID DERIVATIVE; MOLECULAR SCAFFOLD; N (2,6 BIS(3 METHOXYPHENYL)PYRIMIDIN 4 YL)ACETAMIDE; N (2,6 DIARYLPYRIMIDIN 4 YL)ACETAMIDE; N [2,6 BIS(2,3 DIMETHOXYPHENYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS(2,5 DIMETHOXYPHENYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS(2,6 DIMETHOXYPHENYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS(3,4,5 TRIMETHOXYPHENYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS(3,4DIMETHOXYPHENYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS(3,5 DIMETHOXYPHENYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS(4 ETHOXYPHENYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS(4 METHOXYSTYRYL)PYRIMIDIN 4 YL]ACETAMIDE; N [2,6 BIS[4 (TRIFLUOROMETHOXY]PHENYL]PYRIMIDIN 4 YL)ACETAMIDE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; ARYLATION; BINDING AFFINITY; BINDING ASSAY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR MODEL; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEQUENCE ALIGNMENT; SUZUKI REACTION;

ACETAMIDES; ADENOSINE A3 RECEPTOR ANTAGONISTS; ANISOLES; BINDING SITES; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870681703     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.010     Document Type: Article

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