Preliminary study of injury from heating systemically delivered, nontargeted dextran-superparamagnetic iron oxide nanoparticles in mice

Nanomedicine

Volumn 7, Issue 11, 2012, Pages 1697-1711

  Kut, Carmen ^a   Zhang, Yonggang ^a   Hedayati, Mohammad ^a   Zhou, Haoming ^a   Cornejo, Christine ^a   Bordelon, David ^a   Mihalic, Jana ^b   Wabler, Michele ^a   Burghardt, Elizabeth ^a   Gruettner, Cordula ^c   Geyh, Alison ^b   Brayton, Cory ^a   Deweese, Theodore L ^a   Ivkov, Robert ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c MICROMOD PARTIKELTECHNOLOGIE GMBH   (Germany)

Author keywords

hyperthermia; liver; magnetic nanoparticle; SPIO; spleen; toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; DEXTRAN; IRON; LACTATE DEHYDROGENASE; NANOMAG; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVITY; HEATING; HISTOPATHOLOGY; HYPERTHERMIC THERAPY; HYPERTRANSAMINASEMIA; LIVER; LOW DRUG DOSE; MAGNETIC FIELD; MALE; MASS SPECTROMETRY; MICROSCOPE; MORTALITY; MOUSE; NONHUMAN; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; RECTUM TEMPERATURE; SPLEEN; TEMPERATURE MEASUREMENT; THERMAL INJURY; TISSUE NECROSIS; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BODY TEMPERATURE; DEXTRANS; HEATING; LIVER; MAGNETIC FIELDS; MAGNETITE NANOPARTICLES; MALE; MICE; MICE, NUDE; SPLEEN;

EID: 84870606068     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.12.65     Document Type: Article

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