Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Srivastava, Kshitij ^a   Srivastava, Anvesha ^b  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF THE DISTRICT OF COLUMBIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 146A; MICRORNA 149; MICRORNA 196A; MICRORNA 499; SINGLE STRANDED RNA; UNCLASSIFIED DRUG;

ARTICLE; ASIAN; CANCER RISK; CANCER SUSCEPTIBILITY; CAUCASIAN; COLORECTAL CANCER; CONTROLLED STUDY; ETHNICITY; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; LUNG CANCER; META ANALYSIS (TOPIC); SINGLE NUCLEOTIDE POLYMORPHISM;

GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICRORNAS; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PUBLICATION BIAS; RISK FACTORS;

EID: 84870582494     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050966     Document Type: Article

References (94)

1. Ambros V, (2004) The functions of animal microRNAs. Nature 431: 350-355.
2. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
3. Bartel DP, (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
4. Garzon R, Croce CM, (2011) MicroRNAs and Cancer: Introduction. Seminars in Oncology 38: 721-723.
5. Jia Y, Liu H, Zhuang Q, Xu S, Yang Z, et al. (2012) Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. Oncol Rep.
6. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, et al. (2005) MicroRNA expression profiles classify human cancers. Nature 435: 834-838.
7. Volinia S, Calin GA, Liu C-G, Ambs S, Cimmino A, et al. (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proceedings of the National Academy of Sciences of the United States of America 103: 2257-2261.
8. Garzon R, Marcucci G, Croce CM, (2010) Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 9: 775-789.
9. Esquela-Kerscher A, Slack FJ, (2006) Oncomirs [mdash] microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269.
10. Wiemer EA, (2007) The role of microRNAs in cancer: No small matter. European Journal of Cancer 43: 1529-1544.
11. Guo J, Jin M, Zhang M, Chen K, (2012) A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies. PLoS ONE 7: e30585.
12. Cochran WG, (1954) The Combination of Estimates from Different Experiments. Biometrics 10: 101-129.
13. Mantel N, Haenszel W, (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748.
14. DerSimonian R, Laird N, (1986) Meta-analysis in clinical trials. Controlled Clinical Trials 7: 177-188.
15. Woolf B, (1955) On estimating the relation between blood group and disease. Ann Hum Genet 19: 251-253.
16. Thakkinstian A, McElduff P, D'Este C, Duffy D, Attia J, (2005) A method for meta-analysis of molecular association studies. Statistics in Medicine 24: 1291-1306.
17. Trikalinos TA, Salanti G, Khoury MJ, Ioannidis JPA, (2006) Impact of Violations and Deviations in Hardy-Weinberg Equilibrium on Postulated Gene-Disease Associations. American Journal of Epidemiology 163: 300-309.
18. Okubo M, Tahara T, Shibata T, Yamashita H, Nakamura M, et al. (2010) Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population. Helicobacter 15: 524-531.
19. George GP, Gangwar R, Mandal RK, Sankhwar SN, Mittal RD, (2011) Genetic variation in microRNA genes and prostate cancer risk in North Indian population. Mol Biol Rep 38: 1609-1615.
20. Chu Y-H, Tzeng S-L, Lin C-W, Chien M-H, Chen M-K, et al. (2012) Impacts of MicroRNA Gene Polymorphisms on the Susceptibility of Environmental Factors Leading to Carcinogenesis in Oral Cancer. PLoS ONE 7: e39777.
21. Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB, et al. (2008) Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res 68: 2530-2537.
22. Hoffman AE, Zheng T, Yi C, Leaderer D, Weidhaas J, et al. (2009) microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis. Cancer Res 69: 5970-5977.
23. Ye Y, Wang KK, Gu J, Yang H, Lin J, et al. (2008) Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. Cancer Prev Res (Phila) 1: 460-469.
24. Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, et al. (2008) Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proceedings of the National Academy of Sciences 105: 7269-7274.
25. Zhou J, Lv R, Song X, Li D, Hu X, et al. (2011) Association Between Two Genetic Variants in miRNA and Primary Liver Cancer Risk in the Chinese Population. DNA Cell Biol.
26. Xiang Y, Fan S, Cao J, Huang S, Zhang LP (2012) Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep.
27. Pastrello C, Polesel J, Della Puppa L, Viel A, Maestro R, (2010) Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients. Carcinogenesis 31: 2124-2126.
28. Vinci S, Gelmini S, Pratesi N, Conti S, Malentacchi F, et al. (2011) Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers. Clin Chem Lab Med.
29. Kim WH, Min KT, Jeon YJ, Kwon C-I, Ko KH, et al. (2012) Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene 504: 92-97.
30. Jedlinski DJ, Gabrovska PN, Weinstein SR, Smith RA, Griffiths LR, (2011) Single nucleotide polymorphism in hsa-mir-196a-2 and breast cancer risk: a case control study. Twin Res Hum Genet 14: 417-421.
31. Vinci S, Gelmini S, Pratesi N, Conti S, Malentacchi F, et al. (2011) Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers. Clin Chem Lab Med 49: 2073-2080.
32. Lian H, Wang L, Zhang J, (2012) Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans. PLoS One 7: e31615.
33. Xu W, Xu J, Liu S, Chen B, Wang X, et al. (2011) Effects of Common Polymorphisms rs11614913 inmiR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis. PLoS One 6: e20471.
34. Greenland S, Rothman KJ (1998) Measures of effect and measures of association. In Rothman KJ, Greenland S (eds.), Modern epidemiology, 2nd Edition. Philadelphia, PA: Lippincott-Raven. 47-64.
35. Xu T, Zhu Y, Wei Q-K, Yuan Y, Zhou F, et al. (2008) A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis 29: 2126-2131.
36. Li L, Chen XP, Li YJ, (2010) MicroRNA-146a and human disease. Scand J Immunol 71: 227-231.
37. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, et al. (2002) Identification of Tissue-Specific MicroRNAs from Mouse. Current Biology 12: 735-739.
38. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, et al. (2008) Expression of microRNA-146 suppresses NF-[kappa]B activity with reduction of metastatic potential in breast cancer cells. Oncogene 27: 5643-5647.
39. Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, et al. (2009) Breast Cancer Metastasis Suppressor 1 Up-regulates miR-146, Which Suppresses Breast Cancer Metastasis. Cancer Research 69: 1279-1283.
40. Lin S-L, Chiang A, Chang D, Ying S-Y, (2008) Loss of mir-146a function in hormone-refractory prostate cancer. RNA 14: 417-424.
41. Xu W, Xu J, Liu S, Chen B, Wang X, et al. (2011) Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis. PLoS One 6: e20471.
42. Tian T, Xu Y, Dai J, Wu J, Shen H, et al. (2010) Functional polymorphisms in two pre-microRNAs and cancer risk: a meta-analysis. Int J Mol Epidemiol Genet 1: 358-366.
43. Hoffman AE, Zheng T, Yi C, Leaderer D, Weidhaas J, et al. (2009) microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis. Cancer Research 69: 5970-5977.
44. Hu Z, Chen J, Tian T, Zhou X, Gu H, et al. (2008) Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest 118: 2600-2608.
45. Chu H, Wang M, Shi D, Ma L, Zhang Z, et al. (2011) Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies. PLoS ONE 6: e18108.
46. Wang F, Ma Y-L, Zhang P, Yang J-J, Chen H-Q, et al. (2012) A genetic variant in microRNA-196a2 is associated with increased cancer risk: a meta-analysis. Molecular Biology Reports 39: 269-275.
47. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L, (2006) Comparison of Two Methods to Detect Publication Bias in Meta-analysis. JAMA: The Journal of the American Medical Association 295: 676-680.
48. Hu Z, Liang J, Wang Z, Tian T, Zhou X, et al. (2009) Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum Mutat 30: 79-84.
49. Tian T, Shu Y, Chen J, Hu Z, Xu L, et al. (2009) A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese. Cancer Epidemiol Biomarkers Prev 18: 1183-1187.
50. Catucci I, Yang R, Verderio P, Pizzamiglio S, Heesen L, et al. (2010) Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. Hum Mutat 31: E1052-1057.
51. Peng S, Kuang Z, Sheng C, Zhang Y, Xu H, et al. (2010) Association of microRNA-196a-2 gene polymorphism with gastric cancer risk in a Chinese population. Dig Dis Sci 55: 2288-2293.
52. Zhou X, Chen X, Hu L, Han S, Qiang F, et al. (2010) Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women. Gynecol Oncol 117: 287-290.
53. Yang R, Schlehe B, Hemminki K, Sutter C, Bugert P, et al. (2010) A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. Breast Cancer Res Treat 121: 693-702.
54. Xu B, Feng NH, Li PC, Tao J, Wu D, et al. (2010) A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. Prostate 70: 467-472.
55. Qi P, Dou TH, Geng L, Zhou FG, Gu X, et al. (2010) Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection. Hum Immunol 71: 621-626.
56. Dou T, Wu Q, Chen X, Ribas J, Ni X, et al. (2010) A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population. J Cancer Res Clin Oncol 136: 1853-1859.
57. Xu Y, Liu L, Liu J, Zhang Y, Zhu J, et al. (2011) A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer 128: 412-417.
58. Kim MJ, Yoo SS, Choi YY, Park JY, (2010) A functional polymorphism in the pre-microRNA-196a2 and the risk of lung cancer in a Korean population. Lung Cancer 69: 127-129.
59. Christensen BC, Avissar-Whiting M, Ouellet LG, Butler RA, Nelson HH, et al. (2010) Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer. Clin Cancer Res 16: 3713-3720.
60. Srivastava K, Srivastava A, Mittal B, (2010) Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population. J Hum Genet 55: 495-499.
61. Liu Z, Li G, Wei S, Niu J, El-Naggar AK, et al. (2010) Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck. Cancer 116: 4753-4760.
62. Zeng Y, Sun QM, Liu NN, Dong GH, Chen J, et al. (2010) Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population. World J Gastroenterol 16: 3578-3583.
63. Sun Q, Gu H, Zeng Y, Xia Y, Wang Y, et al. (2010) Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. Cancer Sci 101: 2241-2247.
64. Guo H, Wang K, Xiong G, Hu H, Wang D, et al. (2010) A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han. Fam Cancer 9: 599-603.
65. Yang R, Dick M, Marme F, Schneeweiss A, Langheinz A, et al. (2011) Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk. Breast Cancer Res Treat 127: 549-554.
66. Li XD, Li ZG, Song XX, Liu CF, (2010) A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. Pathology 42: 669-673.
67. Chen H, Sun LY, Chen LL, Zheng HQ, Zhang QF (2011) A variant in microRNA-196a2 is not associated with susceptibility to and progression of colorectal cancer in Chinese. Intern Med J.
68. Yue C, Wang M, Ding B, Wang W, Fu S, et al. (2011) Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population. Gynecol Oncol 122: 33-37.
69. Mittal RD, Gangwar R, George GP, Mittal T, Kapoor R, (2011) Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India. DNA Cell Biol 30: 401-406.
70. Zhou B, Wang K, Wang Y, Xi M, Zhang Z, et al. (2011) Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma. Mol Carcinog 50: 499-505.
71. Akkiz H, Bayram S, Bekar A, Akgollu E, Ulger Y, (2011) A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study. J Viral Hepat 18: e399-407.
72. Zhan JF, Chen LH, Chen ZX, Yuan YW, Xie GZ, et al. (2011) A functional variant in microRNA-196a2 is associated with susceptibility of colorectal cancer in a Chinese population. Arch Med Res 42: 144-148.
73. Hong YS, Kang HJ, Kwak JY, Park BL, You CH, et al. (2011) Association between microRNA196a2 rs11614913 genotypes and the risk of non-small cell lung cancer in Korean population. J Prev Med Public Health 44: 125-130.
74. Permuth-Wey J, Thompson RC, Burton Nabors L, Olson JJ, Browning JE, et al. (2011) A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma. J Neurooncol 105: 639-646.
75. Akkiz H, Bayram S, Bekar A, Akgollu E, Uskudar O, et al. (2011) No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: a case-control study. Gene 486: 104-109.
76. Zhu L, Chu H, Gu D, Ma L, Shi D, et al. (2011) A Functional Polymorphism in miRNA-196a2 Is Associated with Colorectal Cancer Risk in a Chinese Population. DNA Cell Biol.
77. Schuetz JM, Daley D, Graham J, Berry BR, Gallagher RP, et al. (2012) Genetic variation in cell death genes and risk of non-hodgkin lymphoma. PLoS One 7: e31560.
78. Wang K, Guo H, Hu H, Xiong G, Guan X, et al. (2010) A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. Biomarkers 15: 614-618.
79. Zhang LS, Liang WB, Gao LB, Li HY, Li LJ, et al. (2011) Association Between pri-miR-218 Polymorphism and Risk of Hepatocellular Carcinoma in a Han Chinese Population. DNA Cell Biol.
80. Zhang M, Jin M, Yu Y, Zhang S, Wu Y, et al. (2012) Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population. European Journal of Cancer Care 21: 274-280.
81. Zhou F, Zhu H, Luo D, Wang M, Dong X, et al. (2012) A Functional Polymorphism in Pre-miR-146a Is Associated with Susceptibility to Gastric Cancer in a Chinese Population. DNA Cell Biol.
82. Smith RA, Jedlinski DJ, Gabrovska PN, Weinstein SR, Haupt L, et al. (2012) A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk. Cancer Genomics Proteomics 9: 115-118.
83. Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, et al. (2011) Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4+3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese. Dig Dis Sci 56: 1131-1137.
84. Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, et al. (2008) Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res 14: 7956-7962.
85. Lung RW-M, Wang X, Tong JH-M, Chau S-L, Lau K-M, et al. (2012) A single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma. Molecular Carcinogenesis: n/a-n/a.
86. Bae JS, Kim J-H, Pasaje CFA, Cheong HS, Lee TH, et al. (2012) Association study of genetic variations in microRNAs with the risk of hepatitis B-related liver diseases. Digestive and Liver Disease.
87. Wang F, Ma YL, Zhang P, Yang JJ, Chen HQ, et al. (2012) A genetic variant in microRNA-196a2 is associated with increased cancer risk: a meta-analysis. Mol Biol Rep 39: 269-275.
88. Chu H, Wang M, Shi D, Ma L, Zhang Z, et al. (2011) Hsa-miR-196a2 Rs11614913 polymorphism contributes to cancer susceptibility: evidence from 15 case-control studies. PLoS One 6: e18108.
89. Gao LB, Bai P, Pan XM, Jia J, Li LJ, et al. (2011) The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 125: 571-574.
90. Qiu LX, He J, Wang MY, Zhang RX, Shi TY, et al. (2011) The association between common genetic variant of microRNA-146a and cancer susceptibility. Cytokine 56: 695-698.
91. Qiu LX, Wang Y, Xia ZG, Xi B, Mao C, et al. (2011) miR-196a2 C allele is a low-penetrant risk factor for cancer development. Cytokine 56: 589-592.
92. Zhang H, Su Y, Yu H, Qian B, (2012) Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility. Cancer Bio Med 9: 63-72.
93. Wang J, Bi J, Liu X, Li K, Di J, et al. (2012) Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies. Molecular Biology Reports 39: 4571-4579.
94. Wang F, Sun G, Zou Y, Fan L, Song B, (2012) Lack of Association of miR-146a rs2910164 Polymorphism with Gastrointestinal Cancers: Evidence from 10206 Subjects. PLoS ONE 7: e39623.