In silico and in vivo evaluation of flavonoid extracts on CYP2D6-mediated herb-drug interaction

Journal of Molecular Modeling

Volumn 18, Issue 10, 2012, Pages 4657-4663

  Su, Zhe ^a   Zhang, Bo ^a   Zhu, Wenliang ^a   Du, Zhimin ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

CYP2D6; CYP450 inhibition; Flavonoid extract; Herb drug interaction

Indexed keywords

CYTOCHROME P450 2D6; FLAVONOID; GINKGO BILOBA EXTRACT; GRAPE SEED EXTRACT; ISOFLAVONE; METOPROLOL; PLANT EXTRACT; SILYBUM MARIANUM EXTRACT; SOY EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STRUCTURE; HERB DRUG INTERACTION; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BLOOD PRESSURE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; CYTOCHROME P-450 CYP2D6; FLAVONOIDS; HEART RATE; HERB-DRUG INTERACTIONS; ISOFLAVONES; MALE; METOPROLOL; MODELS, MOLECULAR; PLANT EXTRACTS; RATS; RATS, WISTAR; REFERENCE STANDARDS; SYSTOLE;

RATTUS;

EID: 84870572356     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-012-1472-6     Document Type: Article

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