Fish oil fatty acids and human platelets: Dose-dependent decrease in dienoic and increase in trienoic thromboxane generation

Biochemical Pharmacology

Volumn 52, Issue 8, 1996, Pages 1211-1217

  Kramer H J ^b   Stevens, J ^b   Grimminger, F ^b   Seeger, W ^a,b  

^a Department of Internal Medicine ^*  (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

arachidonic acid; docosahexaenoic acid; eicosapentaeonic acid; platelets; post HPLC ELISA; thromboxane A2 and A3

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ARACHIDONIC ACID; CALCIMYCIN; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; MEMBRANE PHOSPHOLIPID; OMEGA 3 FATTY ACID; PROSTAGLANDIN SYNTHASE; THROMBIN; THROMBOXANE A2; THROMBOXANE A3; THROMBOXANE B2; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION;

ANIMALS; ARACHIDONIC ACID; BLOOD PLATELETS; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; FISH OILS; HUMANS; KINETICS; THROMBOXANE A2; THROMBOXANE B2; THROMBOXANES;

EID: 0030601849     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00473-X     Document Type: Article

References (36)

1. 1. Weber PC, Fischer S, von Schacky C, Lorenz R and Strasser T, The conversion of dietary eicosapentaenoic acid to prostanoids and leukotrienes in man. Prog Lipid Res 25: 273-276, 1986.
2. 2. Leaf A and Weber PC, Medical progress. Cardiovascular effects of n-3 fatty acids. N Engl J Med 318: 549-557, 1988.
3. 3. Dyerberg J, Bang HO, Stofferson E, Moncada S and Vane JR, Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 15: 117-119, 1978.
4. 4. von Schacky C, Fischer S and Weber PC, Long-term effects of dietary marine n-3 fatty acids upon plasma and cellular lipids, platelet function and eicosanoid formation in humans. J Clin Invest 76: 1626-1631, 1985.
5. 5. Fischer S and Weber PC, The prostacyclin/thromboxane balance is favourably shifted in Greenland eskimos. Prostaglandins 32: 235-241, 1986.
6. 6. Gronn C, Gorbitz E, Christensen A, Levorsen L, Ose L, Hagve TA and Christophersen BO, Dietary n-6 fatty acids inhibit the incorporation of dietary n-3 fatty acids in thrombocyte and serum phospholipids in humans: a controlled dietetic study. Scand. J Clin Lab Invest 51: 255-263, 1991.
7. 7. Needleman P, Raz A, Minkes MS, Ferrendelli JA and Sprecher H, Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci USA 76: 944-948, 1979.
8. 8. Grimminger F, Mayer K, Krämer HJ, Stevens J, Walmrath D and Seeger W, Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2- versus 3-series prostanoid generation. J Pharmacol Exp Ther 267: 259-265, 1993.
9. 9. Croset M, Guichardant M and Lagarde M, Different metabolic behavior of long-chain n-3 polyunsaturated fatty acids in human platelets. Biochim Biophys Acta 961: 262-269, 1988.
10. 10. Chetty N, Vickers JD, Kinlough-Rathbone KL, Packham MA and Mustard JF, Eicosapentaenoic acid interferes with U46619-stimulated formation of inositol phosphates in washed rabbit platelets. Thromb Hemostas 62: 1116-1120, 1989.
11. 11. O'Keefe SF, Lagarde M, Grandgirard A and Sebedio JL, Trans n-3 eicosapentaenoic and docosahexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets compared to the respective cis fatty acids. J Lipid Res 31: 1241-1246, 1990.
12. 12. Bordet JC, Guichardant M and Lagarde M, Modulation of prostanoid formation by various polyunsaturated fatty acids during platelet-endothelial cell interactions. Prostagl Leukotr Essent Fatty Acids 39: 197-202, 1990.
13. 2 receptor binding and function. J Biol Chem 265: 21692-21697, 1990.
14. 2alpha in the epidermis of psoriasis. Proc Natl Acad Sci USA 72: 5130-5135, 1975.
15. 15. Ullrich V, Hecker G and Schatz-Mundig M, Platelet-neutrophil interactions. In: Molecular Aspects of Inflammation. (Eds. Sies H, FlohéL and Zimmer G), pp. 59-71. Springer-Verlag, Berlin, 1991.
16. 16. Unterberg A, Wahl M, Hammersen F and Baethmann A, Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid. Acta Neuropathol 73: 209-219, 1987.
17. 17. Grimminger F, Kreusler B, Schneider U, Becker G and Seeger W, Influence of microvascular adherence on neutrophil leukotriene generation - evidence for cooperative eicosanoid synthesis. J Immunol 144: 1866-1872, 1990.
18. 18. Grimminger F, Sibelius U and Seeger W, Amplification of LTB4 generation in AM-PMN cocultures: transcellular 5-lipoxygenase metabolism. Am J Physiol 261: L195-L203, 1991.
19. 19. Grimminger F, von Kürthen I, Walmrath D and Seeger W, Type II alveolar epithelial eicosanoid metabolism: predominance of cyclooxygenase pathways and transcellular lipoxygenase metabolism in co-culture with neutrophils. Am J Respir Cell Mol Biol 6: 9-16, 1992.
20. 20. Chauncey JB, Peters-Golden M and Simon RH, Arachidonic acid metabolism by rat alveolar epithelial cells. Lab Invest 58: 133-140, 1988.
21. 21. Chauncey JB, Simon RH and Peters-Golden M, Rat alveolar macrophages synthesize leukotriene B4 and 12-hydroxyeicosatetraenoic acid from alveolar epithelial cell-derived arachidonic acid. Am Rev Respir Dis 138: 928-935, 1988.
22. 22. Peterson J, Bihain BE, Bengtsson-Olivecrona G, Deckelbaum RJ, Carpentier YA and Olivecrona T, Fatty acid control of lipoprotein lipase: a link between energy metabolism and lipid transport. Proc Natl Acad Sci USA 87: 909-913, 1990.
23. 23. Lindholm M, Eklund JO, Hamberger B and Järnberg PO, Plasma catecholamine and free fatty acid levels during infusion of lipid emulsion in critically ill patients. Crit Care Med 12: 953-956, 1984.
24. 24. Yamazaki K, Hamazaki T, Yano S, Funada T and Ibuki F, Changes in fatty acid composition in rat blood and organs after infusion of docosahexaenoic acid ethyl ester. Am J Clin Nutr 53: 620-627, 1991.
25. 25. Mascioli EA, Lopes S, Randall S, Porter KA, Kater G, Hirschberg Y, Babayan CK, Bistrian BR and Blackburn GL, Serum fatty acid profiles after intravenous medium chain triglyceride administration. Lipids 24: 793-798, 1989.
26. 26. Grimminger F, Papavasilis C, Führer D, Mayer K, Heuer KU, Pieperhofert ST, Lübbecke F, Krämer HJ, Stevens J, Schütterle G and Seeger W, Influence of long-term n-3 lipid infusion on plasma and membrane fatty acids and lipid mediator generation in a patient with severe ulcerative colitis. Eur J Clin Invest 23: 706-715, 1993.
27. 27. Hamazaki T, Fischer S, Meese CO, Schweer H, Urakaze M, Yokoyama A and Yano S, The infusion of trieicosapentaenoyl-glycerol into humans and the in vivo formation of prostaglandin I3 and thromboxane A3. Biochem Biophys Res Commun 151: 1386-1394, 1988.
28. 28. Hamazaki T, Urakaze M, Yano S, Soda Y, Miyamoto A, Kubota K and Ibuki F, Injection of tridocosahexaenoyl-glycerol emulsion and fatty acid composition of blood cells. Lipids 22: 1031-1034, 1987.
29. 29. Urakaze M, Hamazaki T, Makuta M, Ibuki F, Kobayashi S, Yano S and Kumagai A, Infusion of fish oil emulsion: effects on platelet aggregation and fatty acid composition in phospholipids of plasma, platelets, and red blood cell membranes in rabbits. Am J Clin Nutr 46: 936-940, 1987.
30. 30. Urakaze M, Hamazaki T, Soda Y, Miyamoto A, Ibuki F, Yano S and Kumagai A, Infusion of emulsified trieicosapentaenoyl-glycerol into rabbits-the effects on platelet aggregation, polymorphonuclear leukocyte adhesion, and fatty acid composition in plasma and platelet phospholipids. Thromb Res 44: 673-682, 1986.
31. 31. Grimminger F, Mayser P, Papavassilis C, Thomas M, Schlotzer E, Heuer KU, Hinsch KD, Schill WB and Seeger W, A double-blind, randomised, placebo-controlled trial of n-3 fatty acid-based lipid infusion in acute, extended guttate psoriasis - rapid improvement of clinical manifestation and changes in neutrophil leukotriene profile. Clin Investig 71: 634-643, 1993.
32. 32. Krämer HJ, Stevens J and Seeger W, Analysis of 2- and 3-series prostanoids by post-HPLC-ELISA. Anal Biochem 214: 535-543, 1993.
33. 33. Hatmi M, Lussiana JP, Junien JL, Burke J and Vargaftig BB, Interference of eicosapentaenoic and docosahexaenoic acids with arachidonate-and U46619-induced platelet activation and desensitation. Biochem Pharmacol 37: 481-489, 1987.
34. 34. Hamberg M and Samuelsson B, Prostaglandin endoperoxides. Novel transformation of arachidonic acid in human platelets. Proc Natl Acad Sci USA 71: 3400-3404, 1974.
35. 35. Corey EJ, Sihh C and Cashman JR, Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. Proc Natl Acad Sci USA 80: 3581-3584, 1983.
36. 36. von Shacky C and Weber PC, Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J Clin Invest 76: 2446-2450, 1985.