Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease

Biomarkers

Volumn 17, Issue 8, 2012, Pages 745-749

  Wang, Xin ^a,b   Yong, Huijuan ^a   Mi, Lin ^a   Bai, Yun ^c   Guo, Lijun ^a   Gao, Wei ^a   Cui, Ming ^a   Zhang, Yongzhen ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Angiopoietin 2; Biomarker; Coronary heart disease; Inflammation

Indexed keywords

ANGIOPOIETIN 2; BIOLOGICAL MARKER; C REACTIVE PROTEIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENSINI SCORE; HUMAN; INFLAMMATION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PATIENT MONITORING; PROGNOSIS; PROTEIN BLOOD LEVEL; SCORING SYSTEM; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; UNSTABLE ANGINA PECTORIS;

AGED; ANALYSIS OF VARIANCE; ANGIOPOIETIN-2; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CORONARY DISEASE; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS;

EID: 84870552639     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/1354750X.2012.727028     Document Type: Article

References (27)

1. Cho YJ, Ma JE, Yun EY, Kim YE, Kim HC, Lee JD, Hwang YS, Jeong YY. (2011). Serum angiopoietin-2 levels are elevated during acute exacerbations of COPD. Respirology 16:284-290.
2. Conroy AL, Lafferty EI, Lovegrove FE, Krudsood S, Tangpukdee N, Liles WC, Kain KC. (2009). Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. Malar J 8:295.
3. Eklund L, Olsen BR. (2006). Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp Cell Res 312:630-641.
4. Fam NP, Arab S, Billia F, Han R, Proteau G, Latter D, Errett L, Bonneau D, Dunne R, Liu PP, Stewart DJ. (2010). Increased myocardial expression of angiopoietin-2 in patients undergoing urgent surgical revascularization for acute coronary syndromes. Can J Cardiol 26:365-370.
5. Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG. (2006). Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation. Nat Med 12:235-239.
6. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG. (2004). The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103:4150-4156.
7. Gensini GG. (1983). A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 51:606.
8. Jeon BH, Khanday F, Deshpande S, Haile A, Ozaki M, Irani K. (2003). Tie-ing the antiinflammatory effect of angiopoietin-1 to inhibition of NF-κB. Circ Res 92:586-588.
9. Kim I, Kim JH, Ryu YS, Liu M, Koh GY. (2000). Tumor necrosis factor-α upregulates angiopoietin-2 in human umbilical vein endothelial cells. Biochem Biophys Res Commun 269:361-365.
10. Kim I, Moon SO, Park SK, Chae SW, Koh GY. (2001). Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression. Circ Res 89:477-479.
11. Kwak HJ, Lee SJ, Lee YH, Ryu CH, Koh KN, Choi HY, Koh GY. (2000). Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells. Circulation 101:2317-2324.
12. Lee SH, Wolf PL, Escudero R, Deutsch R, Jamieson SW, Thistlethwaite PA. (2000). Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med 342:626-633.
13. Lemieux C, Maliba R, Favier J, Théorêt JF, Merhi Y, Sirois MG. (2005). Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood 105:1523-1530.
14. Loughna S, Sato TN. (2001). Angiopoietin and Tie signaling pathways in vascular development. Matrix Biol 20:319-325.
15. Mandriota SJ, Pepper MS. (1998). Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ Res 83:852-859.
16. Matsunaga T, Warltier DC, Tessmer J, Weihrauch D, Simons M, Chilian WM. (2003). Expression of VEGF and angiopoietins-1 and -2 during ischemia-induced coronary angiogenesis. Am J Physiol Heart Circ Physiol 285:H352-H358.
17. Michalska-Jakubus M, Kowal-Bielecka O, Chodorowska G, Bielecki M, Krasowska D. (2011). Angiopoietins-1 and -2 are differentially expressed in the sera of patients with systemic sclerosis: High angiopoietin-2 levels are associated with greater severity and higher activity of the disease. Rheumatology (Oxford) 50:746-755.
18. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD. (2010). Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med 38:1845-1851.
19. Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C, Zakynthinos S, Armaganidis A, Papapetropoulos A, Roussos C. (2007). Angiopoietin-2 is increased in severe sepsis: Correlation with inflammatory mediators. Crit Care Med 35:199-206.
20. Page AV, Kotb M, McGeer A, Low DE, Kain KC, Liles WC. (2011). Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. Clin Infect Dis 52:e157-e161.
21. Ricciuto DR, dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, Lafferty EI, Cook DJ, Fox-Robichaud A, Kahnamoui K, Kain KC, Liaw PC, Liles WC. (2011). Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med 39:702-710.
22. Ridker PM, Hennekens CH, Buring JE, Rifai N. (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836-843.
23. Scharpfenecker M, Fiedler U, Reiss Y, Augustin HG. (2005). The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci 118:771-780.
24. Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. (2009). Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock 31:348-353.
25. Tracy RP. (1999). Inflammation markers and coronary heart disease. Curr Opin Lipidol 10:435-441.
26. Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ. (2011). Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. Br J Cancer 104:51-59.
27. Witzenbichler B, Maisonpierre PC, Jones P, Yancopoulos GD, Isner JM. (1998). Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. J Biol Chem 273:18514-18521.