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Physical activity and cancer prevention: A review of current evidence and biological mechanisms
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This review summarizes potential biological mechanisms mediating the association between physical activity and cancer, and highlights evidence from both animal models and human epidemiological studies
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Anzuini F, Battistella A, Izzotti A. Physical activity and cancer prevention: a review of current evidence and biological mechanisms. J Prev Med Hyg. 2011;52(4):174-80. This review summarizes potential biological mechanisms mediating the association between physical activity and cancer, and highlights evidence from both animal models and human epidemiological studies.
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Spence RR, Heesch KC, Brown WJ. A systematic review of the association between physical activity and colorectal cancer risk. Scand J Med Sci Sports. 2009;19(6):764-81.
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Spence, R.R.1
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Friedenreich CM, Neilson HK, Lynch BM. State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer. 2010;46(14):2593-604.
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Friedenreich, C.M.1
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Physical activity and colon cancer prevention: A meta-analysis
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Wolin KY, Yan Y, Colditz GA, Lee IM. Physical activity and colon cancer prevention: a meta-analysis. Br J Cancer. 2009;100 (4):611-6.
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Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer. 2002;101(5):403-8.
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Timing and intensity of recreational physical activity and the risk of subsite-specific colorectal cancer
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This case-control study examines the timing and intensity of recreational physical activity on subsite-specific colorectal cancer risk, showing reductions in distal not proximal colon cancer risk associated with vigorous physical activity. Further, this is one of the few studies to observe an association with rectal cancer
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Boyle T, Heyworth J, Bull F, et al. Timing and intensity of recreational physical activity and the risk of subsite-specific colorectal cancer. Canc Causes Contr. 2011;22(12):1647-58. This case-control study examines the timing and intensity of recreational physical activity on subsite-specific colorectal cancer risk, showing reductions in distal not proximal colon cancer risk associated with vigorous physical activity. Further, this is one of the few studies to observe an association with rectal cancer.
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Canc Causes Contr
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Boyle, T.1
Heyworth, J.2
Bull, F.3
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13
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Too much sitting: The population health science of sedentary behavior
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Owen N, Healy GN, Matthews CE, Dunstan DW. Too much sitting: the population health science of sedentary behavior. Exerc Sport Sci Rev. 2010;38(3):105-13.
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Owen, N.1
Healy, G.N.2
Matthews, C.E.3
Dunstan, D.W.4
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Boyle T, Fritschi L, Heyworth J, Bull F. Long-term sedentary work and the risk of subsite-specific colorectal cancer. Am J Epidemiol. 2011;173(10):1183-91.
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Am J Epidemiol
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Boyle, T.1
Fritschi, L.2
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Bull, F.4
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15
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Body size and colorectal cancer risk after 16.3 years of follow-up: An analysis from the netherlands cohort study
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Hughes LA, Simons CC, van den Brandt PA, et al. Body size and colorectal cancer risk after 16.3 years of follow-up: an analysis from the Netherlands Cohort Study. Am J Epidemiol. 2011;174 (10):1127-39.
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Am J Epidemiol
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Hughes, L.A.1
Simons, C.C.2
Van Den Brandt, P.A.3
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16
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Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med. 2009;361 (25):2449-60.
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N Engl J Med
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Markowitz, S.D.1
Bertagnolli, M.M.2
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17
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Body size, physical activity and risk of colorectal cancer with or without the cpg island methylator phenotype (cimp
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Hughes LA, Simons CC, van den Brandt PA, et al. Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype (CIMP). PLoS One. 2011;6(4): e18571.
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PLoS One
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Hughes, L.A.1
Simons, C.C.2
Van Den Brandt, P.A.3
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18
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79952280377
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Physical activity and risk of colon adenoma: A meta-analysis
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This systematic literature review and meta-analysis examines physical activity/exercise and risk/prevalence of colon adenomas or polyps, which are known precursor lesions of colon cancer, and reports a significant inverse association between physical activity and colon adenomas, suggesting that physical activity can have an important role in preventing lesions that may lead to colon cancer
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Wolin KY, Yan Y, Colditz GA. Physical activity and risk of colon adenoma: a meta-analysis. Br J Cancer. 2011;104(5):882-5. This systematic literature review and meta-analysis examines physical activity/exercise and risk/prevalence of colon adenomas or polyps, which are known precursor lesions of colon cancer, and reports a significant inverse association between physical activity and colon adenomas, suggesting that physical activity can have an important role in preventing lesions that may lead to colon cancer.
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(2011)
Br J Cancer
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Wolin, K.Y.1
Yan, Y.2
Colditz, G.A.3
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19
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Physical activity, biomarkers, and disease outcomes in cancer survivors: A systematic review
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In this article, the authors systematically review studies that examined relationships between physical activity and mortality (cancer-specific and all-cause) and/or cancer biomarkers, concluding consistent evidence exists for reduced allcause, breast cancer-specific, and colon cancer-specific mortality; evidence for other cancers is insufficient, and exercise may result in beneficial changes in the circulating level of insulin, insulinrelated pathways, inflammation, and, possibly, immunity
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Ballard-Barbash R, Friedenreich CM, Courneya KS, et al. Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J Natl Canc Inst. 2012;104 (11):815-40. In this article, the authors systematically review studies that examined relationships between physical activity and mortality (cancer-specific and all-cause) and/or cancer biomarkers, concluding consistent evidence exists for reduced allcause, breast cancer-specific, and colon cancer-specific mortality; evidence for other cancers is insufficient, and exercise may result in beneficial changes in the circulating level of insulin, insulinrelated pathways, inflammation, and, possibly, immunity.
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J Natl Canc Inst
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Ballard-Barbash, R.1
Friedenreich, C.M.2
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20
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The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: A review of the literature
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Davies NJ, Batehup L, Thomas R. The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature. Br J Cancer. 2011;105 Suppl 1:S52-73.
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Br J Cancer
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Davies, N.J.1
Batehup, L.2
Thomas, R.3
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21
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84870505938
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This review summarizes observational studies examining the role of diet and physical activity in breast, colorectal, and prostate cancer survivorship, stating substantial evidence that physical activity can help relieve treatment-related symptoms, such as fatigue, exists, as well as promising data suggesting that physical activity after diagnosis is associated with improved survival. The article briefly describes some of the proposed biological mechanisms including the role of adiposity, metabolic and sex hormones, growth factors, immunological processes and chronic inflammation
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This review summarizes observational studies examining the role of diet and physical activity in breast, colorectal, and prostate cancer survivorship, stating substantial evidence that physical activity can help relieve treatment-related symptoms, such as fatigue, exists, as well as promising data suggesting that physical activity after diagnosis is associated with improved survival. The article briefly describes some of the proposed biological mechanisms including the role of adiposity, metabolic and sex hormones, growth factors, immunological processes and chronic inflammation.
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22
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79955369630
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Association of ctnnb1 (beta-catenin) alterations, body mass index, and physicalactivity with survival in patients with colorectal cancer
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Morikawa T, Kuchiba A, Yamauchi M, et al. Association of CTNNB1 (beta-catenin) alterations, body mass index, and physicalactivity with survival in patients with colorectal cancer. JAMA. 2011;305(16):1685-94.
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Carpenter, C.L.1
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25
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Carpenter, C.L.1
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26
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Iwasaki, M.1
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Physical activity and breast cancer risk in chinese women
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Pronk A, Ji BT, Shu XO, et al. Physical activity and breast cancer risk in Chinese women. Br J Cancer. 2011;105(9):1443-50.
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Awatef M, Olfa G, Rim C, et al. Physical activity reduces breast cancer risk: a case-control study in Tunisia. Canc Epidemiol. 2011;35(6):540-4.
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Physical activity reduces breast cancer risk in african american women
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Sheppard VB, Makambi K, Taylor T, et al. Physical activity reduces breast cancer risk in African American women. Ethn Dis. 2011;21(4):406-11.
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Sheppard, V.B.1
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31
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Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status-The japan public health center-based prospective study
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Suzuki R, Iwasaki M, Yamamoto S, et al. Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status-The Japan Public Health Center-based Prospective Study. Prev Med. 2011;52(3-4):227-33.
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Suzuki, R.1
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32
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79955774979
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Using data from 155,723 women enrolled in the Women's Health Initiative clinical trial and observational cohort, this article assesses associations between body size, recreational physical activity, and risk of triple-negative and estrogen receptor-ositive (ER+) breast cancers, observing a reduction in risk associated with moderate/low-intensity physical activity for ER+tumors only
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Phipps AI, Chlebowski RT, Prentice R, et al. Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. Canc Epidemiol Biomarkers Prev. 2011;20(3):454-63. Using data from 155,723 women enrolled in the Women's Health Initiative clinical trial and observational cohort, this article assesses associations between body size, recreational physical activity, and risk of triple-negative and estrogen receptor-positive (ER+) breast cancers, observing a reduction in risk associated with moderate/low-intensity physical activity for ER+tumors only.
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(2011)
Canc Epidemiol Biomarkers Prev
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Phipps, A.I.1
Chlebowski, R.T.2
Prentice, R.3
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33
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79955785107
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Does hormone therapy counter the beneficial effects of physical activity on breast cancer risk in postmenopausal women?
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Dieli-Conwright CM, Sullivan-Halley J, Patel A, et al. Does hormone therapy counter the beneficial effects of physical activity on breast cancer risk in postmenopausal women? Canc Causes Contr. 2011;22(3):515-22.
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Canc Causes Contr
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Dieli-Conwright, C.M.1
Sullivan-Halley, J.2
Patel, A.3
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80052306420
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Lifetime physical activity and the incidence of proliferative benign breast disease
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This study of 40,318 women enrolled in the Nurses' Health Study II cohort is the first to prospectively examine the association between recreational physical activity and the development of premalignant breast lesions, and suggests that exercise may be inversely associated with the risk of developing proliferative benign breast disease
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Jung MM, Colditz GA, Collins LC, et al. Lifetime physical activity and the incidence of proliferative benign breast disease. Canc Causes Contr. 2011;22(9):1297-305. This study of 40,318 women enrolled in the Nurses' Health Study II cohort is the first to prospectively examine the association between recreational physical activity and the development of premalignant breast lesions, and suggests that exercise may be inversely associated with the risk of developing proliferative benign breast disease.
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(2011)
Canc Causes Contr
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Jung, M.M.1
Colditz, G.A.2
Collins, L.C.3
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35
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79960736818
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Physical activity and survival after breast cancer diagnosis: Meta-analysis of published studies
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This meta-analysis examines studies of associations between pre-diagnosis and post-diagnosis physical activity and breast cancer outcomes, and provides evidence for inverse relationships for reduced all-cause mortality, breast cancer-specific mortality, and disease recurrence
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Ibrahim EM, Al-Homaidh A. Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies. Med Oncol. 2011;28(3):753-65. This meta-analysis examines studies of associations between pre-diagnosis and post-diagnosis physical activity and breast cancer outcomes, and provides evidence for inverse relationships for reduced all-cause mortality, breast cancer-specific mortality, and disease recurrence.
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Med Oncol
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Ibrahim, E.M.1
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36
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Exercise after diagnosis of breast cancer in association with survival
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Chen X, Lu W, Zheng W, et al. Exercise after diagnosis of breast cancer in association with survival. Canc Prev Res (Phila). 2011;4 (9):1409-18.
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Canc Prev Res (Phila
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Chen, X.1
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37
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77957238798
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Physical activity, sedentary behaviours, and the prevention of endometrial cancer
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The authors of this article performed a meta-analysis of studies examining physical activity, sitting time and endometrial cancer, as well as investigated sitting time in relation to endometrial cancer risk using data from the NIH-AARP Diet and Health Study, and conclude that the totality of evidence convincingly indicates that physical activity reduces risk
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Moore SC, Gierach GL, Schatzkin A, Matthews CE. Physical activity, sedentary behaviours, and the prevention of endometrial cancer. Br J Cancer. 2010;103(7):933-8. The authors of this article performed a meta-analysis of studies examining physical activity, sitting time and endometrial cancer, as well as investigated sitting time in relation to endometrial cancer risk using data from the NIH-AARP Diet and Health Study, and conclude that the totality of evidence convincingly indicates that physical activity reduces risk.
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Br J Cancer
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Moore, S.C.1
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39
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Physical activity and endometrial cancer in a population-based case-control study
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Arem H, Irwin ML, Zhou Y, et al. Physical activity and endometrial cancer in a population-based case-control study. Canc Causes Contr. 2011;22(2):219-26.
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Canc Causes Contr
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Arem, H.1
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Does physical activity reduce the risk of prostate cancer? A systematic review and meta-analysis
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This systematic review and meta-analysis summarizes results from 19 cohort and 24 case-control studies, examining the association between physical activity and prostate cancer and suggests a small inverse association between occupational, recreational and total physical activity and prostate cancer risk
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Liu Y, Hu F, Li D, et al. Does physical activity reduce the risk of prostate cancer? A systematic review and meta-analysis. Eur Urol. 2011;60(5):1029-44. This systematic review and meta-analysis summarizes results from 19 cohort and 24 case-control studies, examining the association between physical activity and prostate cancer and suggests a small inverse association between occupational, recreational and total physical activity and prostate cancer risk.
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Eur Urol
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The association between active participation in a sports club, physical activity and social network on the development of lung cancer in smokers: A case-control study
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Schmidt A, Jung J, Ernstmann N, et al. The association between active participation in a sports club, physical activity and social network on the development of lung cancer in smokers: a case-control study. BMC Res Notes. 2012;5:2.
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Leisure-time physical activity and lung cancer: A meta-analysis
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Olsen CM, Bain CJ, Jordan SJ, et al. Recreational physical activity and epithelial ovarian cancer: a case-control study, systematic review, and meta-analysis. Canc Epidemiol Biomarkers Prev. 2007;16(11):2321-30.
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