Extract and fraction from Ulmus wallichiana Planchon promote peak bone achievement and have a nonestrogenic osteoprotective effect

Menopause

Volumn 17, Issue 2, 2010, Pages 393-402

  Sharan, Kunal ^a   Siddiqui, Jawed A ^a   Swarnkar, Gaurav ^a   Tyagi, Abdul Malik ^a   Kumar, Avinash ^a   Rawat, Preeti ^a   Kumar, Manmeet ^a   Nagar, Geet K ^a   Arya, Kamal R ^a   Manickavasagam, Lakshmi ^a   Jain, Girish K ^a   Maurya, Rakesh ^a   Chattopadhyay, Naibedya ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Bone strength; Estrogenicity; Flavonoid C glucosides; Osteogenic; Peak bone mass

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; BUTANOL; COLLAGEN TYPE 1; DRUG VEHICLE; FLAVONOID; HERBACEOUS AGENT; OSTEOCALCIN; PLANT EXTRACT; ULMUS WALLICHIANA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARK; BIOMECHANICS; BONE DENSITY; BONE MARROW CELL; BONE STRENGTH; BONE TURNOVER; CONTROLLED STUDY; DEGRADATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; MEDICINAL PLANT; MENOPAUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPROTECTION; OVARIECTOMY; PLANT STEM; PROPHYLAXIS; RAT; SHAM PROCEDURE; TRABECULAR BONE; ULMUS WALLICHIANA;

ANIMALS; BIOLOGICAL MARKERS; BONE DENSITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FLAVONOIDS; GLYCOSIDES; HUMANS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS, POSTMENOPAUSAL; OVARIECTOMY; PHYTOTHERAPY; PLANT BARK; PLANT PREPARATIONS; PLANT STEMS; RATS; RATS, SPRAGUE-DAWLEY; ULMUS; WEIGHT-BEARING;

EID: 77949407107     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/gme.0b013e3181bfae38     Document Type: Article

References (25)

1. Nassar AH, Abd Essamad HM, Awwad JT, Khoury NG, Usta IM. Gynecologists' attitudes towards hormone therapy in the post BWomen's Health Initiative[study era. Maturitas 2005;52:18-25.
2. Canderelli R, Leccesse LA, Miller NL, Unruh Davidson J. Benefits of hormone replacement therapy in postmenopausal women. J Am Acad Nurse Pract 2007;19:635-641.
3. Coxam V. New advances in osteoporosis nutritional prevention. Med Sci (Paris) 2005;21:297-301.
4. Sharan K, Siddiqui JA, Swarnkar G, Maurya R, Chattopadhyay N. Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharmacokinetic studies. Curr Med Chem 2009;16:1138-1157.
5. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med 2006;27:1-93.
6. Maurya R, Singh G, Yadav PP. Antiosteoporotic agents from natural sources. In: Rahman AU, ed. Studies in Natural Product Chemistry, Bioactive Natural Products. New York, NY: Elsevier, 2008:517-548.
7. Gaur RD. Flora of District Garhwal, North West Himalaya. Srinagar, Garhwal, India: Trans Media, 1999:86.
8. Rawat P, Kumar M, Sharan K, Chattopadhyay N, Maurya R. Ulmosides A and B: flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase. Bioorg Med Chem Lett 2009;19:4684-4687.
9. Maurya R, Rawat P, Sharan K, et al. Novel flavonol compounds, a bioactive extract/fraction from Ulmus wallichiana and its compounds for prevention and treatment of osteo-health related disorders. Pub. No.WO/2009-110003, Pub. date 11-9/2009.
10. Kelsey JL. Risk factors for osteoporosis and associated fractures. Public Health Rep 1989;104:14-20.
11. Seeman E, Tsalamandris C, Formica C. Peak bone mass, a growing problem? Int J Fertil Menopausal Stud 1993;38(Suppl 2):77-82.
12. Bhargavan B, Gautam AK, Singh D, et al. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem 2009;108:388-399.
13. Pastoureau P, Chomel A, Bonnet J. Specific evaluation of localized bone mass and bone loss in the rat using dual-energy X-ray absorptiometry subregional analysis. Osteoporos Int 1995;5:143-149.
14. Trivedi R, Kumar A, Gupta V, et al. Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: possible roles of quercetin and kaempferol. Mol Cell Endocrinol 2009;302:86-91.
15. Trivedi R, Kumar S, Kumar A, et al. Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats. Mol Cell Endocrinol 2008;289:85-93.
16. Maniatopoulos C, Sodek J, Melcher AH. Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 1988;254:317-330.
17. Frost HM, Jee WS. On the rat model of human osteopenias and osteo-poroses. Bone Miner 1992;18:227-236.
18. Kalu DN. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 1991;15:175-191.
19. Comelekoglu U, Bagis S, Yalin S, et al. Biomechanical evaluation in osteoporosis: ovariectomized rat model. Clin Rheumatol 2007;26:380-384.
20. Lin YC, Lyle RM, Weaver CM, et al. Peak spine and femoral neck bone mass in young women. Bone 2003;32:546-553.
21. Orwoll ES, Belknap JK, Klein RF. Gender specificity in the genetic determinants of peak bone mass. J Bone Miner Res 2001;16: 1962-1971.
22. Melville R, Heybroek H. Elms of the Himalaya, Vol.26. Kew, London: Kew Bulletin, 1971.
23. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2007;22:659-661.
24. MacGregor JI, Jordan VC. Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 1998;50:151-196.
25. Neves ECM. Association of ovarian and uterine cancers with postmeno-pausal hormonal treatments. Clin Obstet Gynecol 2008;51:607-617.