Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive c-fiber recruitment after axotomy and regeneration

Journal of Neuroscience

Volumn 32, Issue 49, 2012, Pages 17869-17873

  Jankowski, Michael P ^a   Soneji, Deepak J ^a   Ekmann, Katrina M ^a   Anderson, Collene E ^a   Koerber, H Richard ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX11; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE FIBER C; NERVE FIBER TRANSECTION; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SAPHENOUS NERVE; SPIKE; WESTERN BLOTTING;

ANIMALS; AXOTOMY; GENE KNOCKDOWN TECHNIQUES; HOT TEMPERATURE; MALE; MICE; NERVE FIBERS, UNMYELINATED; NERVE REGENERATION; RECRUITMENT, NEUROPHYSIOLOGICAL; RNA, SMALL INTERFERING; SENSORY RECEPTOR CELLS; SENSORY THRESHOLDS; TRPV CATION CHANNELS;

EID: 84870534070     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3148-12.2012     Document Type: Article

References (19)

1. Bennett DL, Boucher TJ, Armanini MP, Poulsen KT, Michael GJ, Priestley JV, Phillips HS, McMahon SB, Shelton DL (2000) The glial cell line-derived neurotrophic factor family receptor components are differentially regulated within sensory neurons after nerve injury. J Neurosci 20:427-437. Medline
2. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824. CrossRef Medline
3. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288: 306-313. CrossRef Medline
4. Davidson TJ, Harel S, Arboleda VA, Prunell GF, Shelanski ML, Greene LA, Troy CM (2004) Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before Mrna degradation. J Neurosci 24:10040-10046. CrossRef Medline
5. Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187. CrossRef Medline
6. Elitt CM, McIlwrath SL, Lawson JJ, Malin SA, Molliver DC, Cornuet PK, Koerber HR, Davis BM, Albers KM (2006) Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci 26:8578-8587. CrossRef Medline
7. Head H, Sherren J (1905) The consequences of injury to the peripheral nerves in man. Brain 28:116-338. CrossRef
8. Jankowski MP, Cornuet PK, McIlwrath S, Koerber HR, Albers KM (2006) SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth. Neuroscience 143:501-514. CrossRef Medline
9. Jankowski MP, Lawson JJ, McIlwrath SL, Rau KK, Anderson CE, Albers KM, Koerber HR (2009a) Sensitization of cutaneous nociceptors after nerve transection and regeneration: possible role of target-derived neurotrophic factor signaling. J Neurosci 29:1636-1647. CrossRef Medline
10. Jankowski MP, McIlwrath SL, Jing X, Cornuet PK, Salerno KM, Koerber HR, Albers KM (2009b) Sox11 transcription factor modulates peripheral nerve regeneration in adult mice. Brain Res 1256:43-54. CrossRef Medline
11. Jankowski MP, Rau KK, Soneji DJ, Anderson CE, Koerber HR (2010) Enhanced artemin/GFRalpha3 levels regulate mechanically insensitive, heat-sensitive C-fiber recruitment after axotomy and regeneration. J Neurosci 30:16272-16283. CrossRef Medline
12. Jankowski MP, Rau KK, Soneji DJ, Ekmann KM, Anderson CE, Molliver DC, Koerber HR (2012) Purinergic receptor P2Y1 regulates polymodal C-fiber thermal sensitivity during peripheral inflammation. Pain 153:410-419. CrossRef Medline
13. Koerber HR, McIlwrath SL, Lawson JJ, Malin SA, Anderson CE, Jankowski MP, Davis BM (2010) Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers. Mol Pain 6:58. CrossRef Medline
14. Kress M, Koltzenburg M, Reeh PW, Handwerker HO (1992) Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro. J Neurophysiol 68:581-595. Medline
15. Lawson JJ, McIlwrath SL, Woodbury CJ, Davis BM, Koerber HR (2008) TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat. J Pain 9:298-308. CrossRef Medline
16. McIlwrath SL, Lawson JJ, Anderson CE, Albers KM, Koerber HR (2007) Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors. Eur J Neurosci 26:1801-1812. CrossRef Medline
17. Orozco OE, Walus L, Sah DW, Pepinsky RB, Sanicola M (2001) GFRalpha3 is expressed predominantly in nociceptive sensory neurons. Eur J Neurosci 13:2177-2182. CrossRef Medline
18. Ørstavik K, Weidner C, Schmidt R, Schmelz M, Hilliges M, Jørum E, Handwerker H, Torebjörk E (2003) Pathological C-fibres in patients with a chronic painful condition. Brain 126:567-578. CrossRef Medline
19. Tsujino H, Kondo E, Fukuoka T, Dai Y, Tokunaga A, Miki K, Yonenobu K, Ochi T, Noguchi K (2000) Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motorneurons: a novel neuronal marker of nerve injury. Mol Cell Neurosci 15:170-182. CrossRef Medline