Toxicity of the synthetic polymeric 3-alkylpyridinium salt (APS3) is due to specific block of nicotinic acetylcholine receptors

Toxicology

Volumn 303, Issue , 2013, Pages 25-33

  Grandič, Marjana ^a   Aráoz, Romulo ^b   Molgó, Jordi ^b   Turk, Tom ^a   Sepčić, Kristina ^a   Benoit, Evelyne ^b   Frangež, Robert ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b CNRS   (France)

Author keywords

APS3; Motor endplate; Mouse; Nicotinic acetylcholine receptors; Rat; Xenopus oocytes

Indexed keywords

3 ALKYLPYRIDINIUM; NICOTINIC RECEPTOR; POLYMER; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDPLATE POTENTIAL; FEMALE; HEMIDIAPHRAGM; IC 50; IN VITRO STUDY; IN VIVO STUDY; LETHAL DOSE; MALE; MEAN ARTERIAL PRESSURE; MINIATURE ENDPLATE POTENTIAL; MOUSE; MUSCLE ACTION POTENTIAL; MUSCLE CONTRACTION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RENIERA SARAI; SOUTHERN EUROPE; SPONGE (PORIFERA); TACHYCARDIA; TORPEDO; XENOPUS;

ANIMALS; BLOOD PRESSURE; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INHIBITORY CONCENTRATION 50; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; LETHAL DOSE 50; MALE; MICE; MICE, INBRED BALB C; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NICOTINIC ANTAGONISTS; OOCYTES; POLYMERS; PORIFERA; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

MAMMALIA; RATTUS; RENIERA SARAI;

EID: 84870513030     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.10.013     Document Type: Article

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