메뉴 건너뛰기




Volumn 1381, Issue , 2011, Pages 243-253

Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF) for an extended period: Therapeutic implications for multiple sclerosis

Author keywords

Autoimmune diseases; encephalomyelitis; Experimental autoimmune; Multiple sclerosis; Opioid; Opioid growth factor; Opioid growth factor receptor

Indexed keywords

METENKEPHALIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NALTREXONE; OPIATE; OPIATE ANTAGONIST;

EID: 79952283348     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.01.036     Document Type: Article
Times cited : (42)

References (53)
  • 1
    • 67649881102 scopus 로고    scopus 로고
    • Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
    • The Australia and New Zealand Sclerosis Genetics Consortium (ANZgene)
    • The Australia and New Zealand Sclerosis Genetics Consortium (ANZgene) Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 Nat. Genet. 41 2009 824 830
    • (2009) Nat. Genet. , vol.41 , pp. 824-830
  • 2
    • 34547824621 scopus 로고    scopus 로고
    • Enhanced visualization of axonopathy in EAE using thy1-YFP transgenic mice
    • DOI 10.1016/j.jns.2007.03.020, PII S0022510X07002201
    • P. Bannerman, and A. Hahn Enhanced visualization of axon pathology in EAE using thy1-YFP transgenic mice J. Neurol. Sci. 260 2007 23 32 (Pubitemid 47225086)
    • (2007) Journal of the Neurological Sciences , vol.260 , Issue.1-2 , pp. 23-32
    • Bannerman, P.G.1    Hahn, A.2
  • 3
    • 33751560062 scopus 로고    scopus 로고
    • Astrogliosis in EAE spinal cord: Derivation from radial glia, and relationships to oligodendroglia
    • DOI 10.1002/glia.20437
    • P. Bannerman, A. Hahn, A. Soulika, V. Gallo, and D. Pleasure Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia Glia 55 2007 57 64 (Pubitemid 44845509)
    • (2007) GLIA , vol.55 , Issue.1 , pp. 57-64
    • Bannerman, P.1    Hahn, A.2    Soulika, A.3    Gallo, V.4    Pleasure, D.5
  • 4
    • 67651177581 scopus 로고    scopus 로고
    • Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: Therapeutic implications
    • J.L. Bennett, and O. Stuve Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: therapeutic implications Clin. Neuropharm. 32 2009 121 132
    • (2009) Clin. Neuropharm. , vol.32 , pp. 121-132
    • Bennett, J.L.1    Stuve, O.2
  • 6
    • 35948956251 scopus 로고    scopus 로고
    • The Opioid Growth Factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer
    • DOI 10.1158/0008-5472.CAN-07-1922
    • F. Cheng, I.S. Zagon, M.F. Verderame, and P.J. McLaughlin The OGF-OGFr axis utilizes the p16 pathway to inhibit progression of human squamous cell carcinoma of the head and neck Cancer Res. 67 2007 10511 10518 (Pubitemid 350070827)
    • (2007) Cancer Research , vol.67 , Issue.21 , pp. 10511-10518
    • Cheng, F.1    Zagon, I.S.2    Verderame, M.F.3    McLaughlin, P.J.4
  • 8
    • 66149147955 scopus 로고    scopus 로고
    • Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation
    • F. Cheng, P.J. McLaughlin, M.F. Verderame, and I.S. Zagon Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation Exp. Biol. Med. 234 2009 532 541
    • (2009) Exp. Biol. Med. , vol.234 , pp. 532-541
    • Cheng, F.1    McLaughlin, P.J.2    Verderame, M.F.3    Zagon, I.S.4
  • 9
    • 77957166100 scopus 로고    scopus 로고
    • Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin β and Ran for nucleocytoplasmic trafficking
    • F. Cheng, P.J. McLaughlin, and I.S. Zagon Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin β and Ran for nucleocytoplasmic trafficking Exp. Biol. Med. 235 2010 1093 1101
    • (2010) Exp. Biol. Med. , vol.235 , pp. 1093-1101
    • Cheng, F.1    McLaughlin, P.J.2    Zagon, I.S.3
  • 10
    • 77955296499 scopus 로고    scopus 로고
    • Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis
    • B.A.C. Cree, E. Kornyeyeva, and D.S. Goodin Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis Ann. Neurol. 68 2010 145 150
    • (2010) Ann. Neurol. , vol.68 , pp. 145-150
    • Cree, B.A.C.1    Kornyeyeva, E.2    Goodin, D.S.3
  • 11
    • 0018687101 scopus 로고
    • Elevated plasma β-endorphin levels in pregnant women and their neonates
    • DOI 10.1016/0024-3205(79)90541-1
    • K. Csontos, M. Rust, V. Hollt, W. Mahr, W. Kromer, and H.J. Teschemacher Elevated plasma β-endorphin levels in pregnant women and their neonates Life Sci. 25 1979 835 844 (Pubitemid 10229026)
    • (1979) Life Sciences , vol.25 , Issue.10 , pp. 835-844
    • Csontos, K.1    Rust, M.2    Hoellt, V.3
  • 12
    • 0029870593 scopus 로고    scopus 로고
    • Phosphorylation of enkephalins enhances their proteolytic stability
    • DOI 10.1016/0024-3205(96)00057-4
    • C. Dass, and P. Mahalakshmi Phosphorylation of enkephalins enhances their proteolytic stability Life Sci. 58 1996 1039 1045 (Pubitemid 26088527)
    • (1996) Life Sciences , vol.58 , Issue.13 , pp. 1039-1045
    • Dass, C.1    Mahalakshmi, P.2
  • 14
    • 33644836341 scopus 로고    scopus 로고
    • Mechanisms of immunopathology in murine models of central nervous system demyelinating disease
    • A.M. Ercolini, and S.D. Miller Mechanisms of immunopathology in murine models of central nervous system demyelinating disease J. Immunol. 176 2006 3293 3298 (Pubitemid 43363973)
    • (2006) Journal of Immunology , vol.176 , Issue.6 , pp. 3293-3298
    • Ercolini, A.M.1    Miller, S.D.2
  • 16
    • 0033876844 scopus 로고    scopus 로고
    • β-endorphin concentrations in peripheral blood mononuclear cells of patients with multiple sclerosis
    • M. Gironi, V. Martinelli, E. Brambilla, R. Furlan, A.E. Panerai, G. Comi, and P. Sacerdote β-endorphin concentrations in peripheral blood mononuclear cells of patients with multiple sclerosis Arch. Neurol. 57 2000 1178 1181
    • (2000) Arch. Neurol. , vol.57 , pp. 1178-1181
    • Gironi, M.1    Martinelli, V.2    Brambilla, E.3    Furlan, R.4    Panerai, A.E.5    Comi, G.6    Sacerdote, P.7
  • 18
    • 0026319690 scopus 로고
    • Localization of preproenkephalin A mRNA in the neonatal rat retina
    • T. Isayama, and I.S. Zagon Localization of preproenkephalin A mRNA in the neonatal rat retina Brain Res. Bull. 27 1991 805 808
    • (1991) Brain Res. Bull. , vol.27 , pp. 805-808
    • Isayama, T.1    Zagon, I.S.2
  • 19
    • 0026231995 scopus 로고
    • Enkephalins and immune inflammatory reactions
    • B.D. Jankovic Enkephalins and immune inflammatory reactions Acta Neurol. 13 1991 433 441
    • (1991) Acta Neurol. , vol.13 , pp. 433-441
    • Jankovic, B.D.1
  • 20
    • 0023572096 scopus 로고
    • Methods used for the study of opioid receptors
    • F. Leslie Methods used for the study of opioid receptors Pharmacol. Rev. 39 1987 197 249 (Pubitemid 18045485)
    • (1987) Pharmacological Reviews , vol.39 , Issue.3 , pp. 197-249
    • Leslie, F.M.1
  • 21
    • 14744275392 scopus 로고    scopus 로고
    • + T cells prevent murine coronavirus spread to the spinal cord and subsequent demyelination
    • DOI 10.1128/JVI.79.6.3370-3381.2005
    • K.C. MacNamara, M.M. Chua, P.T. Nelson, H. Shen, and S.R. Weiss Increased epitope-specific CD8+ T cells prevent murine coronavirus spread to the spinal cord and subsequent demyelination J. Virol. 79 2005 3370 3381 (Pubitemid 40327925)
    • (2005) Journal of Virology , vol.79 , Issue.6 , pp. 3370-3381
    • MacNamara, K.C.1    Ming, M.C.2    Nelson, P.T.3    Shen, H.4    Weiss, S.R.5
  • 23
    • 64549158395 scopus 로고    scopus 로고
    • Clinically isolated syndrome and multiple sclerosis: Rethinking the arsenal
    • K. Pandey, and F.D. Lublin Clinically isolated syndrome and multiple sclerosis: rethinking the arsenal Curr. Treat. Options Neurol. 11 2009 193 202
    • (2009) Curr. Treat. Options Neurol. , vol.11 , pp. 193-202
    • Pandey, K.1    Lublin, F.D.2
  • 24
    • 10944261736 scopus 로고    scopus 로고
    • Current approved options for treating patients with multiple sclerosis
    • S.A. Rizvi, and M.A. Agius Current approved options for treating patients with multiple sclerosis Neurology 63 2004 S8 S14
    • (2004) Neurology , vol.63
    • Rizvi, S.A.1    Agius, M.A.2
  • 25
    • 0028287238 scopus 로고
    • Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection
    • DOI 10.1016/0006-3223(94)90037-X
    • B.F. Roy, C. Benkelfat, J.L. Hill, P.F. Pierce, M.M. Dauphin, T.M. Kelly, T. Sunderland, D.R. Weinberger, and N. Breslin Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection Biol. Psychiatry 35 1994 335 344 (Pubitemid 24150269)
    • (1994) Biological Psychiatry , vol.35 , Issue.5 , pp. 335-344
    • Roy, B.F.1    Benkelfat, C.2    Hill, J.L.3    Pierce, P.F.4    Dauphin, M.M.5    Kelly, T.M.6    Sunderland, T.7    Weinberger, D.R.8    Breslin, N.9
  • 26
    • 77955144319 scopus 로고    scopus 로고
    • The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis: A randomized placebo-controlled trial
    • N. Sharafaddinzadeh, A. Moghtaderi, D. Kashipazha, N. Majdinasab, and B. Shalbafan The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis: a randomized placebo-controlled trial Mult. Scler. 16 2010 964 969
    • (2010) Mult. Scler. , vol.16 , pp. 964-969
    • Sharafaddinzadeh, N.1    Moghtaderi, A.2    Kashipazha, D.3    Majdinasab, N.4    Shalbafan, B.5
  • 31
    • 34547749000 scopus 로고    scopus 로고
    • Inflammatory processes in the aging mouse brain
    • C.C. Stichel, and H. Luebbert Inflammatory processes in the aging mouse brain Neurobiol. Aging 28 2007 1507 1521
    • (2007) Neurobiol. Aging , vol.28 , pp. 1507-1521
    • Stichel, C.C.1    Luebbert, H.2
  • 32
    • 0030856118 scopus 로고    scopus 로고
    • A critical role for lymphotoxin in experimental allergic encephalomyelitis
    • DOI 10.1084/jem.186.8.1233
    • W.E. Suen, C.M. Bergman, P. Hjelmstrom, and N.H. Ruddle A critical role for lymphotoxin in experimental allergic encephalomyelitis J. Exp. Med. 186 1997 1233 1240 (Pubitemid 27469018)
    • (1997) Journal of Experimental Medicine , vol.186 , Issue.8 , pp. 1233-1240
    • Suen, W.E.1    Bergman, C.M.2    Hjelmstrom, P.3    Ruddle, N.H.4
  • 33
    • 0034898075 scopus 로고    scopus 로고
    • Prolonged gray matter disease without demyelination caused by Theiler's murine encephalomyelitis virus with a mutation in VP2 puff B
    • DOI 10.1128/JVI.75.16.7494-7505.2001
    • I. Tsunoda, Y. Wada, J.E. Libbey, T.S. Cannon, F.G. Whitby, and R.S. Fujinami Prolonged gray matter disease without demyelination caused by Theiler's murine encephalomyelitis virus with a mutation in VP2 puff B J. Virol. 75 2001 7494 7505 (Pubitemid 32738008)
    • (2001) Journal of Virology , vol.75 , Issue.16 , pp. 7494-7505
    • Tsunoda, I.1    Wada, Y.2    Libbey, J.E.3    Cannon, T.S.4    Whitby, F.G.5    Fujinami, R.S.6
  • 35
    • 65249142200 scopus 로고    scopus 로고
    • The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?
    • H.L. Weiner The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann. Neurol. 65 2009 239 248
    • (2009) Ann. Neurol. , vol.65 , pp. 239-248
    • Weiner, H.L.1
  • 36
    • 78649496647 scopus 로고    scopus 로고
    • B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases
    • I.S. Zagon, R.N. Donahue, R.H. Bonneau, and P.J. McLaughlin B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: implication for the treatment of autoimmune diseases Immunobiology 216 2011 173 183
    • (2011) Immunobiology , vol.216 , pp. 173-183
    • Zagon, I.S.1    Donahue, R.N.2    Bonneau, R.H.3    McLaughlin, P.J.4
  • 38
    • 0024510967 scopus 로고
    • Characterization of zeta (ζ): A new opioid receptor involved in growth
    • DOI 10.1016/0006-8993(89)91192-X
    • I.S. Zagon, S.R. Goodman, and P.J. McLaughlin Characterization of zeta (ζ): a new opioid receptor involved in growth Brain Res. 482 1989 297 305 (Pubitemid 19066541)
    • (1989) Brain Research , vol.482 , Issue.2 , pp. 297-305
    • Zagon, I.S.1    Goodman, S.R.2    McLaughlin, P.J.3
  • 39
    • 0027957255 scopus 로고
    • Preproenkephalin mRNA expression in the developing and adult rat brain
    • DOI 10.1016/0169-328X(94)90381-6
    • I.S. Zagon, T. Isayama, and P.J. McLaughlin Preproenkephalin mRNA expression in the developing and adult rat brain Mol. Brain Res. 21 1994 85 98 (Pubitemid 24034913)
    • (1994) Molecular Brain Research , vol.21 , Issue.1-2 , pp. 85-98
    • Zagon, I.S.1    Isayama, T.2    McLaughlin, P.J.3
  • 40
    • 0020565744 scopus 로고
    • Naltrexone modulates tumor response in mice with neuroblastoma
    • I.S. Zagon, and P.J. McLaughlin Naltrexone modulates tumor response in mice with neuroblastoma Science 221 1983 671 673 (Pubitemid 13026087)
    • (1983) Science , vol.221 , Issue.4611 , pp. 671-673
    • Zagon, I.S.1    McLaughlin, P.J.2
  • 41
    • 0020618404 scopus 로고
    • Increased brain size and cellular content in infant rats treated with an opiate antagonist
    • I.S. Zagon, and P.J. McLaughlin Increased brain size and cellular content in infant rats treated with an opiate antagonist Science 221 1983 1179 1180 (Pubitemid 13001230)
    • (1983) Science , vol.221 , Issue.4616 , pp. 1179-1180
    • Zagn, I.S.1    McLaughlin, P.J.2
  • 42
    • 0021259936 scopus 로고
    • Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: A role for endogenous opioid system in cancer
    • DOI 10.1016/0024-3205(84)90651-9
    • I.S. Zagon, and P.J. McLaughlin Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: a role for endogenous opioid systems in cancer Life Sci. 35 1984 409 416 (Pubitemid 14083762)
    • (1984) Life Sciences , vol.35 , Issue.4 , pp. 409-416
    • Zagon, I.S.1    McLaughlin, P.J.2
  • 43
    • 0024357795 scopus 로고
    • Naloxone modulates body and organ growth of rats: Dependency on the duration of opioid receptor blockade and stereospecificity
    • I.S. Zagon, and P.J. McLaughlin Naloxone modulates body and organ growth of rats: dependency on the duration of opioid receptor blockade and stereospecificity Pharmacol. Biochem. Behav. 33 1989 325 328 (Pubitemid 19245514)
    • (1989) Pharmacology Biochemistry and Behavior , vol.33 , Issue.2 , pp. 325-328
    • Zagon, I.S.1    McLaughlin, P.J.2
  • 44
    • 0024327163 scopus 로고
    • Endogenous opioid systems regulate growth of neural tumor cells in culture
    • DOI 10.1016/0006-8993(89)90425-3
    • I.S. Zagon, and P.J. McLaughlin Endogenous opioids regulate growth of neural tumor cells in culture Brain Res. 490 1989 14 25 (Pubitemid 19154956)
    • (1989) Brain Research , vol.490 , Issue.1 , pp. 14-25
    • Zagon, I.S.1    McLaughlin, P.J.2
  • 45
    • 0026026532 scopus 로고
    • Identification of opioid peptides regulating proliferation of neurons and glia in the developing nervous system
    • I.S. Zagon, and P.J. McLaughlin Identification of opioid peptides regulating proliferation of neurons and glia in the developing nervous system Brain Res. 542 1991 318 323
    • (1991) Brain Res. , vol.542 , pp. 318-323
    • Zagon, I.S.1    McLaughlin, P.J.2
  • 46
    • 0029165840 scopus 로고
    • 5]-enkephalin to acute opioid antagonist (naltrexone) exposure
    • 5]-enkephalin to acute opioid antagonist (naltrexone) exposure Mol. Brain Res. 33 1995 111 120
    • (1995) Mol. Brain Res. , vol.33 , pp. 111-120
    • Zagon, I.S.1    McLaughlin, P.J.2
  • 47
    • 70350554076 scopus 로고    scopus 로고
    • Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: A new paradigm for the treatment of multiple sclerosis
    • I.S. Zagon, K.A. Rahn, A.P. Turel, and P.J. McLaughlin Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis Exp. Biol. Med. 234 2009 1383 1392
    • (2009) Exp. Biol. Med. , vol.234 , pp. 1383-1392
    • Zagon, I.S.1    Rahn, K.A.2    Turel, A.P.3    McLaughlin, P.J.4
  • 48
    • 73149104142 scopus 로고    scopus 로고
    • Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis
    • I.S. Zagon, K.A. Rahn, Robert H. Bonneau, A.P. Turel, and P.J. McLaughlin Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis Brain Res. 1310 2010 154 161
    • (2010) Brain Res. , vol.1310 , pp. 154-161
    • Zagon, I.S.1    Rahn, K.A.2    Bonneau, R.H.3    Turel, A.P.4    McLaughlin, P.J.5
  • 49
    • 0037470828 scopus 로고    scopus 로고
    • Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea
    • DOI 10.1016/S0006-8993(02)04172-0
    • I.S. Zagon, T.B. Ruth, A.E. Leure-duPree, J.W. Sassani, and P.J. McLaughlin Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea Brain Res. 967 2003 37 47 (Pubitemid 36324287)
    • (2003) Brain Research , vol.967 , Issue.1-2 , pp. 37-47
    • Zagon, I.S.1    Ruth, T.B.2    Leure-DuPree, A.E.3    Sassani, J.W.4    McLaughlin, P.J.5
  • 51
    • 0033961207 scopus 로고    scopus 로고
    • Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans
    • DOI 10.1016/S0006-8993(99)02330-6, PII S0006899399023306
    • I.S. Zagon, M.F. Verderame, S.S. Allen, and P.J. McLaughlin Cloning, sequencing, chromosomal location, and function of a cDNA encoding the opioid growth factor receptor (OGFr) in humans Brain Res. 856 2000 75 83 (Pubitemid 30085513)
    • (2000) Brain Research , vol.856 , Issue.1-2 , pp. 75-83
    • Zagon, I.S.1    Verderame, M.F.2    Allen, S.S.3    McLaughlin, P.J.4
  • 52
    • 0034141665 scopus 로고    scopus 로고
    • Increased expression of neutral endopeptidase (NEP) and aminopeptidase N (APN) on peripheral blood mononuclear cells in patients with multiple sclerosis
    • DOI 10.1016/S0165-2478(99)00176-5, PII S0165247899001765
    • J. Ziaber, Z. Baj, J. Pasnik, H. Chmielewski, and H. Tchorzewski Increased expression of neutral endopeptidase (NEP) and aminopeptidase N (APN) on peripheral blood mononuclear cells in patients with multiple sclerosis Immunol. Lett. 71 2000 127 129 (Pubitemid 30089776)
    • (2000) Immunology Letters , vol.71 , Issue.2 , pp. 127-129
    • Ziaber, J.1    Baj, Z.2    Pasnik, J.3    Chmielewski, H.4    Tchorzewski, H.5
  • 53
    • 0031744090 scopus 로고    scopus 로고
    • The immunoregulatory abilities of polymorphonuclear neutrophils in the course of multiple sclerosis
    • J. Ziaber, J. Panik, Z. Baj, L. Pokoca, H. Chmielewski, and H. Tchorzewski The immunoregulatory abilities of polymorphonuclear neutrophils in the course of multiple sclerosis Mediat. Inflamm. 7 1999 335 338
    • (1999) Mediat. Inflamm. , vol.7 , pp. 335-338
    • Ziaber, J.1    Panik, J.2    Baj, Z.3    Pokoca, L.4    Chmielewski, H.5    Tchorzewski, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.