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Volumn 29, Issue 1, 2013, Pages 25-29

Vaginal atrophy in breast cancer survivors: Role of vaginal estrogen therapy

Author keywords

Breast cancer survivors; Menopause treatment related; Tamoxifen and aromatase inhibitors therapy; Vaginal estrogen therapy

Indexed keywords

ANASTROZOLE; CONJUGATED ESTROGEN; ESTRADIOL; ESTRIOL; ESTROGEN; EXEMESTANE; LETROZOLE; PLACEBO; TAMOXIFEN;

EID: 84870491284     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2012.705389     Document Type: Article
Times cited : (17)

References (56)
  • 1
    • 0035985483 scopus 로고    scopus 로고
    • Hormone receptors in breast cancer: Racial differences in distribution and survival
    • Joslyn SA. Hormone receptors in breast cancer: racial differences in distribution and survival. Breast Cancer Res Treat 2002;73:45-59.
    • (2002) Breast Cancer Res Treat , vol.73 , pp. 45-59
    • Joslyn, S.A.1
  • 3
    • 0033983713 scopus 로고    scopus 로고
    • Report of the international consensus development conference on female sexual dysfunction: Definitions and classifications
    • Basson R, Berman J, Burnett A, Derogatis L, Ferguson D, Fourcroy J, Goldstein I, et al. Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 2000;163:888-893.
    • (2000) J Urol , vol.163 , pp. 888-893
    • Basson, R.1    Berman, J.2    Burnett, A.3    Derogatis, L.4    Ferguson, D.5    Fourcroy, J.6    Goldstein, I.7
  • 4
    • 0032234366 scopus 로고    scopus 로고
    • Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors
    • Ganz PA, Rowland JH, Meyerowitz BE, Desmond KA. Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors. Recent Results Cancer Res 1998;152:396-411.
    • (1998) Recent Results Cancer Res , vol.152 , pp. 396-411
    • Ganz, P.A.1    Rowland, J.H.2    Meyerowitz, B.E.3    Desmond, K.A.4
  • 5
    • 33750715386 scopus 로고    scopus 로고
    • Quality of life of postmenopausal women in the ATAC ("Arimidex" , tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for early breast cancer
    • ATAC Trialistsa9 Group
    • Cella D, Fallowfield L, Barker P, Cuzick J, Locker G, Howell A; ATAC Trialistsa9 Group. Quality of life of postmenopausal women in the ATAC ("Arimidex", tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for early breast cancer. Breast Cancer Res Treat 2006;100:273-284.
    • (2006) Breast Cancer Res Treat , vol.100 , pp. 273-284
    • Cella, D.1    Fallowfield, L.2    Barker, P.3    Cuzick, J.4    Locker, G.5    Howell, A.6
  • 6
    • 16544365765 scopus 로고    scopus 로고
    • Quality of life of postmenopausal women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial
    • Fallowfield L, Cella D, Cuzick J, Francis S, Locker G, Howell A. Quality of life of postmenopausal women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial. J Clin Oncol 2004;22:4261-4271.
    • (2004) J Clin Oncol , vol.22 , pp. 4261-4271
    • Fallowfield, L.1    Cella, D.2    Cuzick, J.3    Francis, S.4    Locker, G.5    Howell, A.6
  • 7
    • 79956104201 scopus 로고    scopus 로고
    • Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer
    • Hershman DL, Shao T, Kushi LH, Buono D, Tsai WY, Fehrenbacher L, Kwan M, et al. Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Res Treat 2011;126:529-537.
    • (2011) Breast Cancer Res Treat , vol.126 , pp. 529-537
    • Hershman, D.L.1    Shao, T.2    Kushi, L.H.3    Buono, D.4    Tsai, W.Y.5    Fehrenbacher, L.6    Kwan, M.7
  • 8
    • 0035038826 scopus 로고    scopus 로고
    • Tolerability of hormone therapies for breast cancer: How informative are documented symptom profiles in medical notes for 'well-tolerated' treatments?
    • Fellowes D, Fallowfield LJ, Saunders CM, Houghton J. Tolerability of hormone therapies for breast cancer: how informative are documented symptom profiles in medical notes for 'well-tolerated' treatments? Breast Cancer Res Treat 2001;66:73-81.
    • (2001) Breast Cancer Res Treat , vol.66 , pp. 73-81
    • Fellowes, D.1    Fallowfield, L.J.2    Saunders, C.M.3    Houghton, J.4
  • 9
    • 33745543979 scopus 로고    scopus 로고
    • Sexual problems in younger women after breast cancer surgery
    • Burwell SR, Case LD, Kaelin C, Avis NE. Sexual problems in younger women after breast cancer surgery. J Clin Oncol 2006;24:2815-2821.
    • (2006) J Clin Oncol , vol.24 , pp. 2815-2821
    • Burwell, S.R.1    Case, L.D.2    Kaelin, C.3    Avis, N.E.4
  • 11
    • 80053961549 scopus 로고    scopus 로고
    • Simon identifying and treating sexual dysfunction in postmenopausal women: The role of estrogen
    • James A. Simon identifying and treating sexual dysfunction in postmenopausal women: the role of estrogen. J Womens Health 2011;20:1453-1465.
    • (2011) J Womens Health , vol.20 , pp. 1453-1465
    • James, A.1
  • 12
    • 33646188516 scopus 로고    scopus 로고
    • Nonhormonal therapies for menopausal hot flashes: Systematic review and meta-analysis
    • Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, Nicolaidis C, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006;295:2057-2071.
    • (2006) JAMA , vol.295 , pp. 2057-2071
    • Nelson, H.D.1    Vesco, K.K.2    Haney, E.3    Fu, R.4    Nedrow, A.5    Miller, J.6    Nicolaidis, C.7
  • 13
    • 26944497954 scopus 로고    scopus 로고
    • Gabapentin for hot flashes in 420 women with breast cancer: A randomised double-blind placebo-controlled trial
    • Pandya KJ, Morrow GR, Roscoe JA, Zhao H, Hickok JT, Pajon E, Sweeney TJ, et al. Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 2005;366:818-824.
    • (2005) Lancet , vol.366 , pp. 818-824
    • Pandya, K.J.1    Morrow, G.R.2    Roscoe, J.A.3    Zhao, H.4    Hickok, J.T.5    Pajon, E.6    Sweeney, T.J.7
  • 14
    • 78651380678 scopus 로고
    • Comparative study: Replens versus local estrogen in menopausal women
    • Nachtigall LE. Comparative study: replens versus local estrogen in menopausal women. Fertil Steril 1994;6:1178-1180.
    • (1994) Fertil Steril , vol.6 , pp. 1178-1180
    • Nachtigall, L.E.1
  • 15
    • 31544446637 scopus 로고    scopus 로고
    • Menopausal symptoms in women treated for breast cancer: The prevalence and severity of symptoms and their perceived effects on quality of life
    • Gupta P, Sturdee DW, Palin SL, Majumder K, Fear R, Marshall T, Paterson I. Menopausal symptoms in women treated for breast cancer: the prevalence and severity of symptoms and their perceived effects on quality of life. Climacteric 2006;9:49-58.
    • (2006) Climacteric , vol.9 , pp. 49-58
    • Gupta, P.1    Sturdee, D.W.2    Palin, S.L.3    Majumder, K.4    Fear, R.5    Marshall, T.6    Paterson, I.7
  • 17
    • 2442664493 scopus 로고    scopus 로고
    • The impact of hormones on menopausal sexuality: A literature review
    • Bachmann GA, Leiblum SR. The impact of hormones on menopausal sexuality: a literature review. Menopause 2004;11:120-130.
    • (2004) Menopause , vol.11 , pp. 120-130
    • Bachmann, G.A.1    Leiblum, S.R.2
  • 18
    • 68349155731 scopus 로고    scopus 로고
    • Prevalence and impact of vaginal symptoms among postmenopausal women
    • Santoro N, Komi J. Prevalence and impact of vaginal symptoms among postmenopausal women. J Sex Med 2009;6:2133-2142.
    • (2009) J Sex Med , vol.6 , pp. 2133-2142
    • Santoro, N.1    Komi, J.2
  • 19
  • 20
    • 0037176791 scopus 로고    scopus 로고
    • Estrogen replacement reverses ovariectomyinduced vaginal hyperalgesia in the rat
    • Bradshaw HB, Berkley KJ. Estrogen replacement reverses ovariectomyinduced vaginal hyperalgesia in the rat. Maturitas 2002;41:157-165.
    • (2002) Maturitas , vol.41 , pp. 157-165
    • Bradshaw, H.B.1    Berkley, K.J.2
  • 22
  • 23
    • 0031716329 scopus 로고    scopus 로고
    • Metaanalysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: Second report of the Hormones and Urogenital Therapy Committee
    • Cardozo L, Bachmann G, McClish D, Fonda D, Birgerson L. Metaanalysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: second report of the Hormones and Urogenital Therapy Committee. Obstet Gynecol 1998;92:722-727.
    • (1998) Obstet Gynecol , vol.92 , pp. 722-727
    • Cardozo, L.1    Bachmann, G.2    McClish, D.3    Fonda, D.4    Birgerson, L.5
  • 26
    • 33748951949 scopus 로고    scopus 로고
    • A randomized comparative study of the effects of oral and topical estrogen therapy on the vaginal vascularization and sexual function in hysterectomized postmenopausal women
    • Long CY, Liu CM, Hsu SC, Wu CH, Wang CL, Tsai EM. A randomized comparative study of the effects of oral and topical estrogen therapy on the vaginal vascularization and sexual function in hysterectomized postmenopausal women. Menopause 2006;13:737-743.
    • (2006) Menopause , vol.13 , pp. 737-743
    • Long, C.Y.1    Liu, C.M.2    Hsu, S.C.3    Wu, C.H.4    Wang, C.L.5    Tsai, E.M.6
  • 27
    • 79956134351 scopus 로고    scopus 로고
    • IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health
    • on behalf of the International Menopause Society Writing Group
    • Sturdee DW and Pines A on behalf of the International Menopause Society Writing Group. IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health. Climateric 2011;14:302-320.
    • (2011) Climateric , vol.14 , pp. 302-320
    • Sturdee, D.W.1    Pines, A.2
  • 29
    • 58149280795 scopus 로고    scopus 로고
    • Effective treatment of vaginal atrophy with an ultra-low-dose estradiol vaginal tablet
    • Simon J, Nachtigall L, Gut R, Lang E, Archer DF, Utian W. Effective treatment of vaginal atrophy with an ultra-low-dose estradiol vaginal tablet. Obstet Gynecol 2008;112:1053-1060.
    • (2008) Obstet Gynecol , vol.112 , pp. 1053-1060
    • Simon, J.1    Nachtigall, L.2    Gut, R.3    Lang, E.4    Archer, D.F.5    Utian, W.6
  • 30
    • 33644943010 scopus 로고    scopus 로고
    • Menopausal hormone therapy and other breast cancer risk factors in relation to the risk of different histological subtypes of breast cancer: A case-control study
    • Rosenberg LU, Magnusson C, Lindström E, Wedrén S, Hall P, Dickman PW. Menopausal hormone therapy and other breast cancer risk factors in relation to the risk of different histological subtypes of breast cancer: a case-control study. Breast Cancer Res 2006;8:R11.
    • (2006) Breast Cancer Res , vol.8
    • Rosenberg, L.U.1    Magnusson, C.2    Lindström, E.3    Wedrén, S.4    Hall, P.5    Dickman, P.W.6
  • 31
    • 7444259675 scopus 로고    scopus 로고
    • A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
    • Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med 2003;349:1793-1802.
    • (2003) N Engl J Med , vol.349 , pp. 1793-1802
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3    Robert, N.J.4    Muss, H.B.5    Piccart, M.J.6    Castiglione, M.7
  • 32
    • 84862762984 scopus 로고    scopus 로고
    • Vaginal estrogen therapy in postmenopausal breast cancer patients treated with aromatase inhibitors
    • Moegele M, Buchholz S, Seitz S, Ortmann O. Vaginal estrogen therapy in postmenopausal breast cancer patients treated with aromatase inhibitors. Arch Gynecol Obstet 2012;285:1397-1402.
    • (2012) Arch Gynecol Obstet , vol.285 , pp. 1397-1402
    • Moegele, M.1    Buchholz, S.2    Seitz, S.3    Ortmann, O.4
  • 33
    • 79960428256 scopus 로고    scopus 로고
    • Current overview of the management of urogenital atrophy in women with breast cancer
    • Pruthi S, Simon JA, Early AP. Current overview of the management of urogenital atrophy in women with breast cancer. Breast J 2011;17:403-408.
    • (2011) Breast J , vol.17 , pp. 403-408
    • Pruthi, S.1    Simon, J.A.2    Early, A.P.3
  • 34
    • 0026738205 scopus 로고
    • Low-dose oestradiol in the treatment of urogenital oestrogen deficiency - A pharmacokinetic and pharmacodynamic study
    • Nilsson K, Heimer G. Low-dose oestradiol in the treatment of urogenital oestrogen deficiency-a pharmacokinetic and pharmacodynamic study. Maturitas 1992;15:121-127.
    • (1992) Maturitas , vol.15 , pp. 121-127
    • Nilsson, K.1    Heimer, G.2
  • 36
    • 61949094584 scopus 로고    scopus 로고
    • Topical estrogen therapy in the management of postmenopausal vaginal atrophy: An up-to-date overview
    • Al-Baghdadi O, Ewies AA. Topical estrogen therapy in the management of postmenopausal vaginal atrophy: an up-to-date overview. Climacteric 2009;12:91-105.
    • (2009) Climacteric , vol.12 , pp. 91-105
    • Al-Baghdadi, O.1    Ewies, A.A.2
  • 37
    • 0034062255 scopus 로고    scopus 로고
    • Comparison of usefulness of estradiol vaginal tablets and estriol vagitories for treatment of vaginal atrophy
    • Dugal R, Hesla K, Sørdal T, Aase KH, Lilleeidet O, Wickstrøm E. Comparison of usefulness of estradiol vaginal tablets and estriol vagitories for treatment of vaginal atrophy. Acta Obstet Gynecol Scand 2000;79:293-297.
    • (2000) Acta Obstet Gynecol Scand , vol.79 , pp. 293-297
    • Dugal, R.1    Hesla, K.2    Sørdal, T.3    Aase, K.H.4    Lilleeidet, O.5    Wickstrøm, E.6
  • 38
    • 84857508749 scopus 로고    scopus 로고
    • The 2012 hormone therapy position statement of: The North American Menopause Society
    • The 2012 hormone therapy position statement of: The North American Menopause Society. Menopause 2012;19:257-271.
    • (2012) Menopause , vol.19 , pp. 257-271
  • 39
    • 64049083020 scopus 로고    scopus 로고
    • Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women
    • Labrie F, Cusan L, Gomez JL, Côté I, Bérubé R, Bélanger P, Martel C, Labrie C. Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women. Menopause 2009;16:30-36.
    • (2009) Menopause , vol.16 , pp. 30-36
    • Labrie, F.1    Cusan, L.2    Gomez, J.L.3    Côté, I.4    Bérubé, R.5    Bélanger, P.6    Martel, C.7    Labrie, C.8
  • 40
    • 0037354228 scopus 로고    scopus 로고
    • A cohort study of topical vaginal estrogen therapy in women previously treated for breast cancer
    • Dew JE, Wren BG, Eden JA. A cohort study of topical vaginal estrogen therapy in women previously treated for breast cancer. Climacteric 2003;6:45-52.
    • (2003) Climacteric , vol.6 , pp. 45-52
    • Dew, J.E.1    Wren, B.G.2    Eden, J.A.3
  • 41
    • 0031128270 scopus 로고    scopus 로고
    • Estrogen replacement therapy in women with prior diagnosis and treatment for breast cancer
    • Vassilopoulou-Sellin R, Theriault R, Klein MJ. Estrogen replacement therapy in women with prior diagnosis and treatment for breast cancer. Gynecol Oncol 1997; 65:89-93.
    • (1997) Gynecol Oncol , vol.65 , pp. 89-93
    • Vassilopoulou-Sellin, R.1    Theriault, R.2    Klein, M.J.3
  • 43
    • 53049087279 scopus 로고    scopus 로고
    • Practical clinical guidelines for assessing and managing menopausal symptoms after breast cancer
    • Hickey M, Saunders C, Partridge A, Santoro N, Joffe H, Stearns V. Practical clinical guidelines for assessing and managing menopausal symptoms after breast cancer. Ann Oncol 2008;19:1669-1680.
    • (2008) Ann Oncol , vol.19 , pp. 1669-1680
    • Hickey, M.1    Saunders, C.2    Partridge, A.3    Santoro, N.4    Joffe, H.5    Stearns, V.6
  • 44
    • 33645292020 scopus 로고    scopus 로고
    • Caution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors
    • Kendall A, Dowsett M, Folkerd E, Smith I. Caution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors. Ann Oncol 2006;17:584-587.
    • (2006) Ann Oncol , vol.17 , pp. 584-587
    • Kendall, A.1    Dowsett, M.2    Folkerd, E.3    Smith, I.4
  • 45
    • 77952168220 scopus 로고    scopus 로고
    • Low-dose vaginal estrogens or vaginal moisturizer in breast cancer survivors with urogenital atrophy: A preliminary study
    • Biglia N, Peano E, Sgandurra P, Moggio G, Panuccio E, Migliardi M, Ravarino N, et al. Low-dose vaginal estrogens or vaginal moisturizer in breast cancer survivors with urogenital atrophy: a preliminary study. Gynecol Endocrinol 2010;26:404-412.
    • (2010) Gynecol Endocrinol , vol.26 , pp. 404-412
    • Biglia, N.1    Peano, E.2    Sgandurra, P.3    Moggio, G.4    Panuccio, E.5    Migliardi, M.6    Ravarino, N.7
  • 46
    • 78649278103 scopus 로고    scopus 로고
    • Recommendations for the management of postmenopausal vaginal atrophy
    • International Menopause Society Writing Group
    • Sturdee DW, Panay N; International Menopause Society Writing Group. Recommendations for the management of postmenopausal vaginal atrophy. Climacteric 2010;13:509-522.
    • (2010) Climacteric , vol.13 , pp. 509-522
    • Sturdee, D.W.1    Panay, N.2
  • 48
    • 79959949594 scopus 로고    scopus 로고
    • Hormone replacement therapy and women with premature menopause - A cancer survivorship issue
    • King J, Wynne CH, Assersohn L, Jones A. Hormone replacement therapy and women with premature menopause - a cancer survivorship issue. Eur J Cancer 2011;47:1623-1632.
    • (2011) Eur J Cancer , vol.47 , pp. 1623-1632
    • King, J.1    Wynne, C.H.2    Assersohn, L.3    Jones, A.4
  • 49
    • 80051783908 scopus 로고    scopus 로고
    • Vaginal DHEA to treat menopause related atrophy: A review of the evidence
    • Panjari M, Davis SR. Vaginal DHEA to treat menopause related atrophy: a review of the evidence. Maturitas 2011;70:22-25.
    • (2011) Maturitas , vol.70 , pp. 22-25
    • Panjari, M.1    Davis, S.R.2
  • 51
    • 77956639804 scopus 로고    scopus 로고
    • DHEA, important source of sex steroids in men and even more in women
    • Labrie F. DHEA, important source of sex steroids in men and even more in women. Prog Brain Res 2010;182:97-148.
    • (2010) Prog Brain Res , vol.182 , pp. 97-148
    • Labrie, F.1
  • 52
    • 72249101980 scopus 로고    scopus 로고
    • Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women
    • Labrie F, Archer D, Bouchard C, Fortier M, Cusan L, Gomez JL, Girard G, et al. Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women. Menopause 2009;16:923-931.
    • (2009) Menopause , vol.16 , pp. 923-931
    • Labrie, F.1    Archer, D.2    Bouchard, C.3    Fortier, M.4    Cusan, L.5    Gomez, J.L.6    Girard, G.7
  • 53
    • 0037123341 scopus 로고    scopus 로고
    • Endogenous sex hormones and breast cancer in postmenopausal women: Reanalysis of nine prospective studies
    • Endogenous Hormones and Breast Cancer Collaborative Group
    • Key T, Appleby P, Barnes I, Reeves G; Endogenous Hormones and Breast Cancer Collaborative Group. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002;94:606-616.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 606-616
    • Key, T.1    Appleby, P.2    Barnes, I.3    Reeves, G.4
  • 54
    • 78651400545 scopus 로고    scopus 로고
    • A Phase II study of vaginal testosterone cream vs. estring for vaginal dryness or decreased libido in women with early stage breast cancer treated with aromatase inhibitors
    • [Abstract nr 5038]
    • Melisko M, Rugo H, DeLuca A, Park J, Moasser M, Munster P, Goldman M, et al. A Phase II study of vaginal testosterone cream vs. estring for vaginal dryness or decreased libido in women with early stage breast cancer treated with aromatase inhibitors. Cancer Res 2009;69:[Abstract nr 5038].
    • (2009) Cancer Res , vol.69
    • Melisko, M.1    Rugo, H.2    Deluca, A.3    Park, J.4    Moasser, M.5    Munster, P.6    Goldman, M.7
  • 55
    • 79955556336 scopus 로고    scopus 로고
    • Topical testosterone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: A phase I/II study
    • Witherby S, Johnson J, Demers L, Mount S, Littenberg B, Maclean CD, Wood M, Muss H. Topical testosterone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: a phase I/II study. Oncologist 2011;16:424-431.
    • (2011) Oncologist , vol.16 , pp. 424-431
    • Witherby, S.1    Johnson, J.2    Demers, L.3    Mount, S.4    Littenberg, B.5    MacLean, C.D.6    Wood, M.7    Muss, H.8
  • 56
    • 77949345161 scopus 로고    scopus 로고
    • Estrogen and progestogen use in postmenopausal women: 2010 position statement of the North American Menopause Society
    • Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society. Position Statement. Menopause 2010;17:242-255.
    • (2010) Position Statement. Menopause , vol.17 , pp. 242-255


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