Effects of chronic sildenafil use on pulmonary hemodynamics and clinical outcomes in heart transplantation

Journal of Heart and Lung Transplantation

Volumn 31, Issue 12, 2012, Pages 1281-1287

  Pons, Jaume ^a   Leblanc, Marie Hélène ^a   Bernier, Mathieu ^a   Cantin, Bernard ^a   Bourgault, Christine ^a   Bergeron, Sebastien ^a   Proulx, Guy ^a   Morin, Joelle ^a   Nalli, Chiara ^a   O'Connor, Kim ^a   Chateauvert, Nathalie ^a   Sénéchal, Mario ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

heart failure; heart transplant; pulmonary hemodynamics; pulmonary vascular resistance; sildenafil

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FUROSEMIDE; INOTROPIC AGENT; MILRINONE; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; SPIRONOLACTONE; VASODILATOR AGENT;

ADULT; ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; DISEASE SEVERITY; DRUG DOSE TITRATION; DRUG EFFECT; DRUG TOLERABILITY; DRUG USE; DRUG WITHDRAWAL; FEMALE; GASTROINTESTINAL TOXICITY; HEART ASSIST DEVICE; HEART FAILURE; HEART TRANSPLANTATION; HEMODYNAMICS; HIGH RISK PATIENT; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; INTRAOPERATIVE PERIOD; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RETROSPECTIVE STUDY; SURVIVAL RATE; TREATMENT OUTCOME;

FEMALE; HEART FAILURE; HEART TRANSPLANTATION; HEMODYNAMICS; HUMANS; HYPERTENSION, PULMONARY; LUNG; MALE; MIDDLE AGED; PERIOPERATIVE PERIOD; PIPERAZINES; PURINES; SULFONES; TREATMENT OUTCOME; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 84870488340     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2012.09.009     Document Type: Article

References (33)

1. V.V. McLaughlin, S.L. Archer, and D.M. Badesch ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association J Am Coll Cardiol 53 2009 1573 1619
2. J.F. Delgado, E. Conde, and V. Sánchez Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure Eur J Heart Fail 7 2005 1011 1016
3. A. Costard-Jäckle, and M.B. Fowler Influence of preoperative pulmonary artery pressure on mortality after heart transplantation: testing of potential reversibility of pulmonary hypertension with nitroprusside is useful in defining a high risk group J Am Coll Cardiol 19 1992 48 54
4. J.F. Delgado, M.A. Gómez-Sánchez, and C. Sáez de la Calzada Impact of mild pulmonary hypertension on mortality and pulmonary artery pressure profile after heart transplantation J Heart Lung Transplant 20 2001 942 948
5. H.K. Kirklin, D.C. Naftel, and R.C. Bourge Evolving trends in risk profiles and causes of death after heart transplantation: a ten-year multi-institutional study J Thorac Cardiovasc Surg 125 2003 881 890
6. M.R. Mehra, J. Kobashigawa, and R. Starling Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates - 2006 J Heart Lung Transplant 25 2006 1024 1042
7. J.M. Chen, H.R. Levin, and R.E. Michler Reevaluating the significance of pulmonary hypertension before cardiac transplantation: determination of optimal thresholds and quantification of the effect of reversibility on perioperative mortality J Thorac Cardiovasc Surg 114 1997 627 634
8. M.R. Costanzo, S. Augustine, and R. Bourge Selection and treatment of candidates for heart transplantation. A statement for health professionals from the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association Circulation 92 1995 3593 3612
9. J. Alaeddini, P.A. Uber, and M.H. Park Efficacy and safety of sildenafil in the evaluation of pulmonary hypertension in severe heart failure Am J Cardiol 94 2004 1475 1477
10. M. Angel Gómez-Sánchez, C. Saenz De La Calzada, and P. Escribano Subías Pilot assessment of the response of several pulmonary hemodynamic variables to sublingual sildenafil in candidates for heart transplantation Eur J Heart Fail 6 2004 615 617
11. G.D. Lewis, J. Lachmann, and J. Camuso Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure Circulation 115 2007 59 66
12. G.D. Lewis, R. Shah, and K. Shahzad Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension Circulation 116 2007 1555 1562
13. M. Guazzi, M. Samaja, and R. Arena Long-term use of sildenafil in the therapeutic management of heart failure J Am Coll Cardiol 50 2007 2136 2144
14. G. Torre-Amione, R.E. Southard, and M.M. Loebe Reversal of secondary pulmonary hypertension by axial and pulsatile mechanical circulatory support J Heart Lung Transplant 29 2010 195 200
15. A.C. Alba, V. Rao, and H.J. Ross Impact of fixed pulmonary hypertension on post-heart transplant outcomes in bridge-to-transplant patients J Heart Lung Transplant 29 2010 1253 1258
16. E. Mikus, A. Stepanenko, and T. Krabatsch Reversibility of fixed pulmonary hypertension in left ventricular assist device support recipients Eur J Cardiothrac Surg 40 2011 971 977
17. E. Mikus, A. Stepanenko, and T. Krabatsch Left ventricular assist device or heart transplantation: impact of transpulmonary gradient and pulmonary vascular resistance on decision making Eur J Cardiothorac Surg 39 2011 310 316
18. M.M. Givertz, J.M. Hare, and E. Loh Effect of bolus milrinone on hemodynamic variables and pulmonary vascular resistance in patients with severe left ventricular dysfunction: a rapid test for reversibility of pulmonary hypertension J Am Coll Cardiol 28 1996 1775 1780
19. N. Kieler-Jensen, S.E. Ricksten, and O. Stenqvist Inhaled nitric oxide in the evaluation of heart transplant candidates with elevated pulmonary vascular resistance J Heart Lung Transplant 13 1994 366 375
20. W.A. Zoghbi, M. Enriquez-Sarano, and E. Foster Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography J Am Soc Echocardiogr 16 2003 777 802
21. M.B. Sorensen, N.E. Bille-Brahe, and H.C.C.O. Engell measurement by thermal dilution: reproducibility and comparison with the dye-dilution technique Ann Surg 183 1976 67 72
22. D.O. Taylor, J. Stehlik, and L.B. Edwards Registry of the International Society for Heart and Lung Transplantation: twenty-sixth official adult heart transplant report-2009 J Heart Lung Transplant 28 2009 1007 1022
23. D.O. Taylor, L.B. Edwards, and M.M. Boucek The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult heart transplant report-2004 J Heart Lung Transplant 23 2004 796 803
24. A. Jabbour, A. Keogh, and C. Hayward Chronic sildenafil lowers transpulmonary gradient and improves cardiac output allowing successful heart transplantation Eur J Heart Fail 9 2007 674 677
25. F. Perez-Villa, M. Farrero, and A. Sionis Therapy with sildenafil or bosentan decreases pulmonary vascular resistance in patients ineligible for heart transplantation because of severe pulmonary hypertension J Heart Lung Transplant 29 2010 817 818
26. C.D. Etz, H.A. Welp, and T.D. Tjam Medically refractory pulmonary hypertension: treatment with nonpulsatile left ventricular assist devices Ann Thorac Surg 83 2007 1697 1705
27. B. Stobierska-Dzierzek, H. Awad, and R.E. Michler The evolving management of acute right-sided heart failure in cardiac transplant recipients J Am Coll Cardiol 38 2001 923 931
28. A. Kulkarni, T.P. Singh, and A. Sarnaik Sildenafil for pulmonary hypertension after heart transplantation J Heart Lung Transplant 23 2004 1441 1444
29. M. Maruzewski, M. Zakliczyński, and R. Przybylski Use of sildenafil in heart transplant recipients with pulmonary hypertension may prevent right heart failure Transplant Proc 39 2007 2850 2852
30. M. Boffini, F. Sansone, and F. Ceresa Role of oral sildenafil in the treatment of right ventricular dysfunction after heart transplantation Transplant Proc 41 2009 1353 1356
31. S. Goland, L.S. Czer, and R.M. Kass Pre-existing pulmonary hypertension in patients with end-stage heart failure: impact on clinical outcome and hemodynamic follow-up after orthotopic heart transplantation J Heart Lung Transplant 26 2007 312 318
32. S. Murali, R.L. Kormos, and B.F. Uretsky Preoperative pulmonary hemodynamics and early mortality after orthotopic cardiac transplantation: the Pittsburgh experience Am Heart J. 126 1993 896 904
33. J.K. Kirklin, D.C. Naftel, and R.L. Kormos Third INTERMACS Annual Report: the evolution of destination therapy in the United States J Heart Lung Transplant 30 2011 115 123