Targeting β-tubulin: CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation

Cell Death and Disease

Volumn 3, Issue 11, 2012, Pages

  Lin, Y F ^a   Lee, Y F ^b   Liang, P H ^a,b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

tubulin; Apoptosis; Capacitative Ca2+ entry; Caspases; CCT

Indexed keywords

APOPTOSOME; BETA TUBULIN; CALCIUM ION; CASPASE; CELL PROTEIN; CHAPERONIN CONTAINING TCP1; HEAT SHOCK PROTEIN 90; PROTEASOME; VALOSIN CONTAINING PROTEIN;

APOPTOSIS; ARTICLE; CELL FUNCTION; CELL VACUOLE; CONTROLLED STUDY; CYTOSKELETON; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ADENOSINE TRIPHOSPHATASES; APOPTOSIS; CALCIUM; CASPASES; CELL CYCLE PROTEINS; CELL LINE; CHAPERONIN CONTAINING TCP-1; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MITOCHONDRIA; PROTEIN BINDING; PROTEOLYSIS; TUBULIN;

EID: 84870481883     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.173     Document Type: Article

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