Removal of Polycomb Repressive Complex 2 Makes C. elegans Germ Cells Susceptible to Direct Conversion into Specific Somatic Cell Types

Cell Reports

Volumn 2, Issue 5, 2012, Pages 1178-1186

  Patel, Tulsi ^a   Tursun, Baris ^a,b   Rahe, Dylan P ^a   Hobert, Oliver ^a  

^a NewYork Presbyterian Hospital   (United States)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE METHYLTRANSFERASE; MES 4 PROTEIN; MYOD PROTEIN; NEURON TYPE SPECIFIC TRANSCRIPTION FACTOR; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CONTROLLED STUDY; GERM CELL; HISTONE METHYLATION; MITOSIS; MUSCLE CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SOMATIC CELL; ZYGOTE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENOME; GERM CELLS; HISTONES; METHYLATION; MUSCLE CELLS; NEURONS; NUCLEAR PROTEINS; POLYCOMB REPRESSIVE COMPLEX 2; REPRESSOR PROTEINS; RNA INTERFERENCE;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 84870451265     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.09.020     Document Type: Article

References (38)

1. Bender L.B., Cao R., Zhang Y., Strome S. The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans. Curr. Biol. 2004, 14:1639-1643.
2. Capowski E.E., Martin P., Garvin C., Strome S. Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. Genetics 1991, 129:1061-1072.
3. Chang S., Johnston R.J., Hobert O. A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans. Genes Dev. 2003, 17:2123-2137.
4. Duerr J.S. Immunohistochemistry. WormBook 2006, 19:1-61.
5. Edelstein A., Amodaj N., Hoover K., Vale R., Stuurman N. Computer control of microscopes using microManager. Curr. Protoc. Mol. Biol. 2010, Chapter 14. Unit14.20.
6. Egli D., Birkhoff G., Eggan K. Mediators of reprogramming: transcription factors and transitions through mitosis. Nat. Rev. Mol. Cell Biol. 2008, 9:505-516.
7. Etchberger J.F., Lorch A., Sleumer M.C., Zapf R., Jones S.J., Marra M.A., Holt R.A., et al. The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Genes Dev. 2007, 21:1653-1674.
8. Fire A., Waterston R.H. Proper expression of myosin genes in transgenic nematodes. EMBO J. 1989, 8:3419-3428.
9. Fox P.M., Vought V.E., Hanazawa M., Lee M.H., Maine E.M., Schedl T. Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. Development 2011, 138:2223-2234.
10. Francis G.R., Waterston R.H. Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization. J. Cell. Biol. 1985, 101:1532-1549.
11. Fukushige T., Krause M. The myogenic potency of HLH-1 reveals wide-spread developmental plasticity in early C. elegans embryos. Development 2005, 132:1795-1805.
12. Fukushige T., Brodigan T.M., Schriefer L.A., Waterston R.H., Krause M. Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development. Genes Dev. 2006, 20:3395-3406.
13. Furuta T., Tuck S., Kirchner J., Koch B., Auty R., Kitagawa R., Rose A.M., Greenstein D. EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Mol. Biol. Cell 2000, 11:1401-1419.
14. Gaydos L., Rechtsteiner A., Egelhofer T., Carroll C., Strome S. Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells. Cell Rep. 2012, Published online October 25, 2012. 10.1016/j.celrep.2012.09.019.
15. Hanna J., Saha K., Pando B., van Zon J., Lengner C.J., Creyghton M.P., van Oudenaarden A., Jaenisch R. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009, 462:595-601.
16. Harrison M.M., Ceol C.J., Lu X., Horvitz H.R. Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. USA 2006, 103:16782-16787.
17. Hobert O., Moerman D.G., Clark K.A., Beckerle M.C., Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J. Cell Biol. 1999, 144:45-57.
18. Holdeman R., Nehrt S., Strome S. MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein. Development 1998, 125:2457-2467.
19. Korf I., Fan Y., Strome S. The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Development 1998, 125:2469-2478.
20. Krause M., Park M., Zhang J.M., Yuan J., Harfe B., Xu S.Q., Greenwald I., Cole M., Paterson B., Fire A. A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development. Development 1997, 124:2179-2189.
21. Kuzmichev A., Nishioka K., Erdjument-Bromage H., Tempst P., Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002, 16:2893-2905.
22. Lei H., Fukushige T., Niu W., Sarov M., Reinke V., Krause M. A widespread distribution of genomic CeMyoD binding sites revealed and cross validated by ChIP-Chip and ChIP-Seq techniques. PLoS ONE 2010, 5:e15898.
23. Loyola A., Almouzni G. Histone chaperones, a supporting role in the limelight. Biochim. Biophys. Acta 2004, 1677:3-11.
24. Margueron R., Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011, 469:343-349.
25. Ono K., Yu R., Mohri K., Ono S. Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle. Mol. Biol. Cell 2006, 17:2722-2734.
26. Poole R.J., Bashllari E., Cochella L., Flowers E.B., Hobert O. A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans. PLoS Genet. 2011, 7:e1002109.
27. Raj A., van den Bogaard P., Rifkin S.A., van Oudenaarden A., Tyagi S. Imaging individual mRNA molecules using multiple singly labeled probes. Nat. Methods 2008, 5:877-879.
28. Rechtsteiner A., Ercan S., Takasaki T., Phippen T.M., Egelhofer T.A., Wang W., Kimura H., Lieb J.D., Strome S. The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny. PLoS Genet. 2010, 6:6.
29. Sijen T., Fleenor J., Simmer F., Thijssen K.L., Parrish S., Timmons L., Plasterk R.H., Fire A. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell 2001, 107:465-476.
30. Tursun B., Cochella L., Carrera I., Hobert O. A toolkit and robust pipeline for the generation of fosmid-based reporter genes in C. elegans. PLoS ONE 2009, 4:e4625.
31. Tursun B., Patel T., Kratsios P., Hobert O. Direct conversion of C. elegans germ cells into specific neuron types. Science 2011, 331:304-308.
32. Uchida O., Nakano H., Koga M., Ohshima Y. The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons. Development 2003, 130:1215-1224.
33. van Steensel B. Chromatin: constructing the big picture. EMBO J. 2011, 30:1885-1895.
34. Xu L., Fong Y., Strome S. The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos. Proc. Natl. Acad. Sci. USA 2001, 98:5061-5066.
35. Yuan W., Xu M., Huang C., Liu N., Chen S., Zhu B. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J. Biol. Chem. 2011, 286:7983-7989.
36. Yuzyuk T., Fakhouri T.H., Kiefer J., Mango S.E. The Polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos. Dev. Cell 2009, 16:699-710.
37. Zhang Z., Jones A., Sun C.W., Li C., Chang C.W., Joo H.Y., Dai Q., Mysliwiec M.R., Wu L.C., Guo Y., et al. PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells 2011, 29:229-240.
38. Zhou Q., Melton D.A. Extreme makeover: converting one cell into another. Cell Stem Cell 2008, 3:382-388.