PTP1B inhibitor improves both insulin resistance and lipid abnormalities in vivo and in vitro

Molecular and Cellular Biochemistry

Volumn 357, Issue 1-2, 2011, Pages 65-72

  Ma, Yi Ming ^a   Tao, Rong Ya ^a   Liu, Qian ^a   Li, Juan ^a   Tian, Jin Ying ^a   Zhang, Xiao Lin ^a   Xiao, Zhi Yan ^a   Ye, Fei ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Hepatocytes; Insulin resistance; Lipid accumulation; Ptp1B

Indexed keywords

CCF 06240; INSULIN; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; ROSIGLITAZONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; FATTY ACID; PHENYLPROPIONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B; PTPN1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL STRAIN HEPG2; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FATTY ACID SYNTHESIS; FUNCTION TEST; HYPERINSULINEMIC EUGLYCEMIC CLAMP TEST; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMAN; LIPID METABOLISM; LIPOGENESIS; LIVER CELL; METABOLISM;

MUS;

ANIMALS; BENZOFURANS; BLOOD GLUCOSE; BODY WEIGHT; FATTY ACIDS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HEPATOCYTES; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; MICE; PHENYLPROPIONATES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SIGNAL TRANSDUCTION;

EID: 84870413569     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0876-4     Document Type: Article

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