Methods of solving rapid binding target-mediated drug disposition model for two drugs competing for the same receptor

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 39, Issue 5, 2012, Pages 543-560

  Yan, Xiaoyu ^a   Chen, Yang ^a   Krzyzanski, Wojciech ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Erythropoietin; FcRn; Gaddum equation; Target mediated drug disposition; Therapeutic antibody

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; FC RECEPTOR; IMMUNOGLOBULIN G; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN;

ALGORITHM; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER PROGRAM; COMPUTER SIMULATION; DRUG COMPETITION; DRUG RECEPTOR BINDING; HOMEOSTASIS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROBABILITY; PROCESS DEVELOPMENT; PROCESS MODEL; STEADY STATE; TARGET MEDIATED DRUG DISPOSITION;

BINDING, COMPETITIVE; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; ERYTHROPOIETIN; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, FC; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84870408909     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-012-9267-z     Document Type: Article

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