Identification of novel NaV1.7 antagonists using high throughput screening platforms

Combinatorial Chemistry and High Throughput Screening

Volumn 15, Issue 9, 2012, Pages 713-720

  Klement, Göran ^a   Babich, Olga ^b   Larsson, Olof ^a   Lund, Per Eric ^a   Malmberg, Åsa ^a   Sandberg, Lars ^a   Sands, Zara A ^c   Dabrowski, Michael ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b Chromocell Corporation   (United States)

^c UCB PHARMA   (Belgium)

Author keywords

Analgesic; Antagonist; IonWorks; Screening protocol; Sodium ion channel; State dependence; Use dependence

Indexed keywords

ANALGESIC AGENT; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.7; SODIUM CHANNEL NAV1.7 BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DEPOLARIZATION; DRUG SCREENING; ELECTROPHYSIOLOGY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; LOSS OF FUNCTION MUTATION; NERVE CELL; PRIORITY JOURNAL;

CELLS, CULTURED; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR STRUCTURE; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870400770     PISSN: 13862073     EISSN: 18755402     Source Type: Journal    
DOI: 10.2174/138620712803519680     Document Type: Article

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