Cancer spectrum in DNA mismatch repair gene mutation carriers: Results from a hospital based Lynch syndrome registry

Familial Cancer

Volumn 11, Issue 3, 2012, Pages 441-447

  Pande, Mala ^a   Wei, Chongjuan ^a   Chen, Jinyun ^a   Amos, Christopher I ^a   Lynch, Patrick M ^a   Lu, Karen H ^a   Lucio, Laura A ^a   Boyd Rogers, Stephanie G ^a   Bannon, Sarah A ^a   Mork, Maureen E ^a   Frazier, Marsha L ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Colorectal; Extracolonic; Index cancer; Lynch syndrome cancers

Indexed keywords

MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADULT; AGED; ARTICLE; BLADDER CANCER; BRAIN CANCER; BREAST CANCER; CANCER RISK; COLORECTAL CANCER; DISEASE ASSOCIATION; DISEASE REGISTRY; ENDOMETRIUM CANCER; EXTRACOLONIC CANCER; FEMALE; GENE MUTATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOTE; HUMAN; KIDNEY CANCER; LUNG ADENOCARCINOMA; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MELANOMA; MISMATCH REPAIR; NEOPLASM; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SEX DIFFERENCE; SINUS CAVITY CANCER; SMALL INTESTINE CANCER; STOMACH CANCER; THYMOMA; THYROID CANCER; UTERINE CERVIX CANCER;

ADENOCARCINOMA; ADULT; BREAST NEOPLASMS; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; FEMALE; HETEROZYGOTE; HUMANS; LUNG NEOPLASMS; MALE; MELANOMA; MIDDLE AGED; MUTATION; PROSTATIC NEOPLASMS; REGISTRIES; TEXAS; THYROID NEOPLASMS;

EID: 84870400389     PISSN: 13899600     EISSN: 15737292     Source Type: Journal    
DOI: 10.1007/s10689-012-9534-6     Document Type: Article

References (28)

1. Geary J, Sasieni P, Houlston R, Izatt L, Eeles R, Payne SJ, Fisher S, Hodgson SV (2008) Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). Fam Cancer 7:163-172
2. Pinol V, Castells A, Andreu M, Castellvi-Bel S, Alenda C, Llor X, Xicola RM, Rodriguez-Moranta F, Paya A, Jover R, Bessa X (2005) Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA 293:1986-1994
3. Salovaara R, Loukola A, Kristo P, Kaariainen H, Ahtola H, Eskelinen M, Harkonen N, Julkunen R, Kangas E, Ojala S, Tulikoura J, Valkamo E, Jarvinen H, Mecklin JP, Aaltonen LA, de la Chapelle A (2000) Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol 18: 2193-2200
4. Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, Clendenning M, Sotamaa K, Prior T, Westman JA, Panescu J, Fix D, Lockman J, LaJeunesse J, Comeras I, de la Chapelle A (2008) Feasibility of screening for Lynch syndrome among patients with colorectal cancer. J Clin Oncol 26: 5783-5788
5. Lynch HT, Ens J, Lynch JF, Watson P (1988) Tumor variation in three extended Lynch syndrome II kindreds. Am J Gastroenterol 83:741-747
6. Lynch HT, Lynch JF (1993) The Lynch syndromes. Curr Opin Oncol 5:687-696
7. Lin KM, Shashidharan M, Ternent CA, Thorson AG, Blatchford GJ, Christensen MA, Lanspa SJ, Lemon SJ, Watson P, Lynch HT (1998) Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population. Dis Colon Rectum 41:428-433
8. da Silva FC, de Oliveira LP, Santos EM, Nakagawa WT, Aguiar JS, Valentin MD, Rossi BM, de Oliveira FF (2010) Frequency of extracolonic tumors in Brazilian families with Lynch syndrome: analysis of a hereditary colorectal cancer institutional registry. Fam Cancer 9:563-570
9. Watson P, Riley B (2005) The tumor spectrum in the Lynch syndrome. Fam Cancer 4:245-248
10. Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the international collaborative group on HNPCC. Gastroenterology 116:1453-1456
11. Lynch HT, Fusaro RM, Roberts L, Voorhees GJ, Lynch JF (1985) Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome. Br J Dermatol 113: 295-301
12. Schwartz RA, Torre DP (1995) The Muir-Torre syndrome: a 25-year retrospect. J Am Acad Dermatol 33:90-104
13. Giardiello FM (1997) Genetic testing in hereditary colorectal cancer. JAMA 278:1278-1281
14. Peltomaki P, Vasen HF (1997) Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International collaborative group on hereditary nonpolyposis colorectal cancer. Gastroenterology 113:1146-1158
15. Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, Cavalieri RJ, Boland CR (1993) Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 104: 1535-1549
16. Vasen HF, Stormorken A, Menko FH, Nagengast FM, Kleibeuker JH, Griffioen G, Taal BG, Moller P, Wijnen JT (2001) MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. J Clin Oncol 19:4074-4080
17. Bai YQ, Akiyama Y, Nagasaki H, Lu SL, Arai T, Morisaki T, Kitamura M, Muto A, Nagashima M, Nomizu T, Iwama T, Itoh H, Baba S, Iwai T, Yuasa Y (1999) Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. Int J Cancer 82:512-515
18. Kim JC, Kim HC, Roh SA, Koo KH, Lee DH, Yu CS, Lee JH, Kim TW, Lee HL, Beck NE, Bodmer WF (2001) hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer. Cancer Detect Prev 25:503-510
19. Rossi BM, Lopes A, Oliveira FF, Nakagawa WT, Napoli Ferreira CC, Casali Da Rocha JC, Simpson CC, Simpson AJ (2002) hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer. Ann Surg Oncol 9:555-561
20. Liu M, Scheurer ME, Bondy ML, Strom SS, Amos CI, Etzel CJ (2007) Extension of the cohort analysis for genetic epidemiology program to assess excess risk of cancer. American Statistical Association. Proceeding of the 2007 Joint Statistical Meeting, pp 2546-2550
21. Bandipalliam P, Garber J, Kolodner RD, Syngal S (2004) Clinical presentation correlates with the type of mismatch repair gene involved in hereditary nonpolyposis colon cancer. Gastroenterology 126:936-937
22. Jensen UB, Sunde L, Timshel S, Halvarsson B, Nissen A, Bernstein I, Nilbert M (2010) Mismatch repair defective breast cancer in the hereditary nonpolyposis colorectal cancer syndrome. Breast Cancer Res Treat 120:777-782
23. Walsh MD, Buchanan DD, Cummings MC, Pearson SA, Arnold ST, Clendenning M, Walters R, McKeone DM, Spurdle AB, Hopper JL, Jenkins MA, Phillips KD, Suthers GK, George J, Goldblatt J, Muir A, Tucker K, Pelzer E, Gattas MR, Woodall S, Parry S, Macrae FA, Haile RW, Baron JA, Potter JD, Le ML, Bapat B, Thibodeau SN, Lindor NM, McGuckin MA, Young JP (2010) Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry. Clin Cancer Res 16:2214-2224
24. Muller A, Edmonston TB, Corao DA, Rose DG, Palazzo JP, Becker H, Fry RD, Rueschoff J, Fishel R (2002) Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. Cancer Res 62:1014-1019
25. de Leeuw WJ, van PM, Tollenaar RA, Cornelisse CJ, Vasen HF, Morreau H (2003) Correspondence re: A. Muller et al., Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. Cancer Res 63:1148-1149
26. Vasen HF, Morreau H, Nortier JW (2001) Is breast cancer part of the tumor spectrum of hereditary nonpolyposis colorectal cancer? Am J Hum Genet 68:1533-1535
27. Bauer CM, Ray AM, Halstead-Nussloch BA, Dekker RG, Raymond VM, Gruber SB, Cooney KA (2011) Hereditary prostate cancer as a feature of Lynch syndrome. Fam Cancer 10:37-42
28. Grindedal EM, Moller P, Eeles R, Stormorken AT, Bowitz-Lothe IM, Landro SM, Clark N, Kvale R, Shanley S, Maehle L (2009) Germ-line mutations in mismatch repair genes associated with prostate cancer. Cancer Epidemiol Biomarkers Prev 18: 2460-2467