hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer

Annals of Surgical Oncology

Volumn 9, Issue 6, 2002, Pages 555-561

  Rossi, Benedito Mauro ^a   Lopes, Ademar ^a   Ferreira, Fabio Oliveira ^a   Nakagawa, Wilson Toshihiko ^a   Napoli Ferreira, Cláudia C ^a   Casali Da Rocha, José C ^a   Simpson, Catarina C ^a   Simpson, Andrew J G ^b  

^a A C CAMARGO CANCER CENTER   (Brazil)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

Author keywords

Hereditary colorectal cancer; hMLH1; hMSH2; HNPCC; Lynch syndrome; Mutation detection

Indexed keywords

PROTEIN; PROTEIN MUTL; PROTEIN MUTS; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SUSCEPTIBILITY; CHROMOSOME BAND; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DNA POLYMORPHISM; FAMILIAL CANCER; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; HUMAN; MALE; MUTATIONAL ANALYSIS; ONSET AGE;

ADOLESCENT; ADULT; AGED; BRAZIL; CARRIER PROTEINS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA-BINDING PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PEDIGREE; POLYMORPHISM, GENETIC; PROTO-ONCOGENE PROTEINS; SEQUENCE ANALYSIS, DNA;

EID: 0036069287     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1245/aso.2002.9.6.555     Document Type: Article

References (43)

1. Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II)
2. Hereditary nonpolyposis colorectal cancer (Lynch syndrome): An updated review
3. Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
4. Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome
5. Evolution of hereditary non-polyposis colorectal cancer
6. Clinical manifestations in patients with hereditary nonpolyposis colorectal cancer
7. Hereditary colorectal tumors: Routine care and the multidisciplinary therapeutic approach
8. Population-based detection of hereditary nonpolyposis colorectal cancer
9. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC
10. Hereditary colorectal tumors
11. Predominant germ-line mutation of the hMSH2 and hMLH1 gene in Japanese hereditary non-polyposis colorectal cancer kindreds
12. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
13. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
14. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
15. Mutation of a mutL homolog in hereditary colon cancer
16. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
17. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
18. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
19. hMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden
20. HNPCC associated with germline mutations in the TGF-β type II receptor gene
21. MSH2 genomic deletions are a frequent cause of HNPCC
22. Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms
23. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
24. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
25. A National Cancer Institute workshop on hereditary nonpolyposis colorectal cancer syndrome: Meeting highlights and Bethesda guidelines
26. Genomic structure of human mismatch repair gene hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC)
27. A novel mutation at exon 7 of the MSH2 gene (1249delG) in a large HNPCC Brazilian kindred
28. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
29. Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer families
30. DGGE screening of mutations in mismatch repair genes (hMLH1 and hMSH2) in 34 Swedish families with colorectal cancer
31. Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas
32. Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part I: Studies of cancer families
33. Mean age of tumor onset in hereditary nonpolyposis colorectal cancer (HNPCC) families correlates with the presence of mutations in mismatch repair genes
34. Germ-line mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer
35. Recognition and treatment of patients with hereditary nonpolyposis colon cancer (Lynch syndromes I and II)
36. Testing tumors for microsatellite instability
37. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred
38. Germ-line mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
39. Germ-line mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer
40. Genetic services for familial cancer patients: A survey of National Cancer Institute cancer centers
41. Recommendations for follow-up care of individuals with an inherited predisposition to cancer