Maternal high-fat diet modulates the fetal thyroid axis and thyroid gene expression in a nonhuman primate model

Molecular Endocrinology

Volumn 26, Issue 12, 2012, Pages 2071-2080

  Suter, Melissa A ^a   Sangi Haghpeykar, Haleh ^a   Showalter, Lori ^a   Shope, Cynthia ^a   Hu, Min ^a   Brown, Kathleen ^a   Williams, Sarah ^b   Alan Harris, R ^a   Grove, Kevin L ^b   Lane, Robert H ^c   Aagaard, Kjersti M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; FATTY ACID; HISTONE; IODOTHYRONINE; LIOTHYRONINE; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR BETA; THYROXINE; THYROXINE BINDING GLOBULIN; THYROXINE DEIODINASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; EPIGENETICS; EXPERIMENTAL MODEL; FEMALE; FETUS; FETUS LIVER; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GENE EXPRESSION; GENETIC TRANSCRIPTION; HOMEOSTASIS; HORMONE RESPONSIVE ELEMENT; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; LIPID DIET; MACACA; MALE; MATERNAL NUTRITION; METABOLIC DISORDER; NONHUMAN; OBESITY; OVERNUTRITION; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR OCCUPANCY; SLC5A5 GENE; TG GENE; THIRD TRIMESTER PREGNANCY; TPO GENE; TRH GENE; TSHR GENE;

ANIMALS; DIET, HIGH-FAT; DIETARY FATS; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; HYPOTHYROIDISM; IODIDE PEROXIDASE; LIVER; MACACA; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROMOTER REGIONS, GENETIC; THYROID GLAND; THYROID HORMONE RECEPTORS BETA; THYROID HORMONES;

PRIMATES;

EID: 84870387080     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1214     Document Type: Article

References (42)

1. Reinehr T 2010 Obesity and thyroid function. Mol Cell Endocrinol 316:165-171
2. Herwig A, Ross AW, Nilaweera KN, Morgan PJ, Barrett P 2008 Hypothalamic thyroid hormone in energy balance regulation. Obes Facts 1:71-79
3. Davies TF, Yin X, Latif R 2010 The genetics of the thyroid stimulating hormone receptor: history and relevance. Thyroid 20:727-736
4. Nillni EA 2010 Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs. Front Neuroendocrinol 31:134-156
5. Suzuki K, Mori A, Lavaroni S, Ulianich L, Miyagi E, Saito J, Nakazato M, Pietrarelli M, Shafran N, Grassadonia A, Kim WB, Consiglio E, Formisano S, Kohn LD 1999 Thyroglobulin regulates follicular function and heterogeneity by suppressing thyroid-specific gene expression. Biochimie 81:329-340
6. Guo F, Bakal K, Minokoshi Y, Hollenberg AN 2004 Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology 145:2221-2227
7. Maia AL, Goemann IM, Meyer EL, Wajner SM 2011 Deiodinases: the balance of thyroid hormone: type 1 iodothyronine deiodinase in human physiology and disease. J Endocrinol 209:283-297
8. Bianco AC 2011 Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology
9. Wu Y, Koenig RJ 2000 Gene regulation by thyroid hormone. Trends Endocrinol Metab 11:207-211
10. Cheng SY, Leonard JL, Davis PJ 2010 Molecular aspects of thyroid hormone actions. Endocr Rev 31:139-170
11. Williams GR 2000 Cloning and characterization of two novel thyroid hormone receptor + isoforms. Mol Cell Biol 20:8329-8342
12. Mitsuhashi T, Tennyson GE, NikodemVM1988 Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone. Proc Natl Acad Sci USA 85:5804-5808
13. Brent GA, Dunn MK, Harney JW, Gulick T, Larsen PR, Moore DD 1989 Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol 1:329-336
14. Glass CK, Lipkin SM, Devary OV, Rosenfeld MG 1989 Positive and negative regulation of gene transcription by a retinoic acidthyroid hormone receptor heterodimer. Cell 59:697-708
15. Casanova J, Horowitz ZD, Copp RP, McIntyre WR, Pascual A, Samuels HH 1984 Photoaffinity labeling of thyroid hormone nuclear receptors. Influence of n-butyrate and analysis of the half-lives of the 57,000 and 47,000 molecular weight receptor forms. J Biol Chem 259:12084-12091
16. Havis E, Sachs LM, Demeneix BA 2003 Metamorphic T3-response genes have specific co-regulator requirements. EMBO Rep 4:883-888
17. Jones PL, Sachs LM, Rouse N, Wade PA, Shi YB 2001 Multiple N-CoR complexes contain distinct histone deacetylases. J Biol Chem 276:8807-8811
18. Jeyakumar M, Liu XF, Erdjument-Bromage H, Tempst P, Bagchi MK2007 Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem 282:9312-9322
19. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM 1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
20. Matsushita A, Sasaki S, Kashiwabara Y, Nagayama K, Ohba K, Iwaki H, Misawa H, Ishizuka K, Nakamura H 2007 Essential role of GATA2 in the negative regulation of thyrotropin + gene by thyroid hormone and its receptors. Mol Endocrinol 21:865-884
21. Lazar MA 1993 Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr Rev 14:184-193
22. Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG 1999 Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell 3:361-370
23. Wong J, Shi YB, Wolffe AP 1995 A role for nucleosome assembly in both silencing and activation of the Xenopus TR + A gene by the thyroid hormone receptor. Genes Dev 9:2696-2711
24. Ranjan M, Wong J, Shi YB 1994 Transcriptional repression of Xenopus TR + gene is mediated by a thyroid hormone response element located near the start site. J Biol Chem 269:24699-24705
25. Suzuki S, Miyamoto T, Opsahl A, Sakurai A, DeGroot LJ 1994 Two thyroid hormone response elements are present in the promoter of human thyroid hormone receptor + 1. Mol Endocrinol 8:305-314
26. Obregon MJ, Calvo RM, Del Rey FE, de Escobar GM 2007 Ontogenesis of thyroid function and interactions with maternal function. Endocr Dev 10:86-98
27. Calvo RM, Jauniaux E, Gulbis B, Asunción M, Gervy C, Contempré B, Morreale de Escobar G 2002 Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development. J Clin Endocrinol Metab 87:1768-1777
28. Hume R, Simpson J, Delahunty C, van Toor H, Wu SY, Williams FL, Visser TJ 2004 Human fetal and cord serum thyroid hormones: developmental trends and interrelationships. J Clin Endocrinol Metab 89:4097-4103
29. Li Y, Shan Z, Teng W, Yu X, Fan C, Teng X, Guo R, Wang H, Li J, Chen Y, Wang W, Chawinga M, Zhang L, Yang L, Zhao Y, Hua T 2010 Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months. Clin Endocrinol 72:825-829
30. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ 1999 Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549-555
31. Roti E, Gnudi A, Braverman LE 1983 The placental transport, synthesis and metabolism of hormones and drugs which affect thyroid function. Endocr Rev 4:131-149
32. McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, Grove KL 2009 Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 119:323-335
33. Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, Lane RH 2008 Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 41:91-102
34. Suter M, Bocock P, Showalter L, Hu M, Shope C, McKnight R, Grove K, Lane R, Aagaard-Tillery K 2011 Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates. FASEB J 25:714-726
35. Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2([minus++C(T) method. Methods 25:402-408
36. O'Brien T, Dinneen SF, O'Brien PC, Palumbo PJ 1993 Hyperlipidemia in patients with primary and secondary hypothyroidism. Mayo Clin Proc 68:860-866
37. Nader NS, Bahn RS, Johnson MD, Weaver AL, Singh R, Kumar S 2010 Relationships between thyroid function and lipid status or insulin resistance in a pediatric population. Thyroid 20:1333-1339
38. Campbell MC, Anderson GW, Mariash CN 2003 Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification. Endocrinology 144: 5242-5248
39. Feng X, Jiang Y, Meltzer P, Yen PM 2000 Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray. Mol Endocrinol 14:947-955
40. Suter MA, Aagaard-Tillery KM 2009 Environmental influences on epigenetic profiles. Semin Reprod Med 27:380-390
41. Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME 2009 Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab 94:3521-3529
42. Wiench M, Miranda TB, Hager GL 2011 Control of nuclear receptor function by local chromatin structure. FEBS J 278:2211-2230