Role of supplementary L-carnitine in exercise and exercise recovery

Medicine and Sport Science

Volumn 59, Issue , 2013, Pages 135-142

  Huang, Amy ^a   Owen, Kevin ^a  

^a LONZA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84870358895     PISSN: 02545020     EISSN: 16622812     Source Type: Book Series    
DOI: 10.1159/000341934     Document Type: Article

References (33)

1. Flanagan JL, Simmons PA, Vehige J, Willcox MDP, Garrett Q: Role of carnitine in disease. Nutr Metab (Lond) 2010;7:30-44.
2. Krähenbuhl S: l-Carnitine and vegetarianism. Ann Nutr Metab 2000;44:75-96.
3. Knüttel-Gustavesen S, Harmeyer J: The determination of l-carnitine in several food samples. Food Chem 2007;105:793-804.
4. Schreurs M, Kuipers F, van der Leij FR: Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome. Obes Rev 2010;11:380-388.
5. Karlic H, Lohninger S, Koeck T, Lohninger A: Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats. J Histochem Cytochem 2002;50:205-212.
6. Müller DM, Seim H, Kiess W, Löster H, Richter T: Effects of oral l-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism 2002;51:1389-1391.
7. Wutzke KD, Lorenz H: The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Metabolism 2004;53:1002-1006.
8. Stephens FB, Constantin-Teodosiu D, Greenhaff PL: New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol 2007;581.2:431-444.
9. Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL: Chronic oral ingestion of l-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol 2011;589.4:963-973.
10. Barnett C, Costill DL, Vukovich MD, Cole KJ, Goodpaster BH, Trappe SW, Fink WJ: Effect of l-carnitine supplementation on muscle and blood carnitine content and lactate accumulation during high-intensity sprint cycling. Int J Sport Nutr 1994; 4:280-288.
11. Vukovich MD, Costill DL, Fink WJ: Carnitine supplementation: effect on muscle carnitine and glycogen content during exercise. Med Sci Sports Exerc 1994;26:1122-1129.
12. Iyer RN, Khan AA, Gupta A, Vajifdar BU, Lokhandwala YY: l-Carnitine moderately improves the exercise tolerance in chronic stable angina. J Assoc Physicians India 2000;48:1050-1052.
13. Cacciatore L, Cerio R, Ciarimboli M, Cocozza M, Coto V, D'Alessandro A, D'Alessandro L, Grattarola G, Imparato L, Lingetti M, Mancini M, Oliviero U, Policicchio D, Porfido FA, Rengo F, Sorrentino GP: The therapeutic effect of l-carnitine in patients with exercise-induced stable angina: a controlled study. Drugs Exp Clin Res 1991;17:225-235.
14. Cherchi A, Lai C, Angelino F, Trucco G, Caponnetto S, Mereto PE, Rosolen G, Manzoli U, Schiavoni G, Reale A, Romeo F, Rizzon P, Sorgente L, Strano A, Novo S, Immordino R: Effects of l-carnitine on exercise tolerance in chronic stable angina: a multicenter, double-blind, randomized placebo controlled crossover study. Int J Clin Pharm Ther Toxicol 1985;23:569-572.
15. Swart I, Rossouw J, Loots JM, Kruger MC: The effect of l-carnitine supplementation on plasma carnitine levels and various performance parameters of male marathon athletes. Nutr Res 1997;17: 405-414.
16. Vecchiet L, DiLisa F, Pieralisi G, Ripari P, Menabo R, Giamberadino MA, Siliprandi N: Influence of l-carnitine administration on maximal physical exercise. Eur J Appl Physiol 1990;61:486-490.
17. Krähenbuhl S: l-Carnitine and physical performance. Ann Nutr Metab 2000;44:75-96.
18. Dubelaar M-L, Lucas C, Hülsman WC: The effect of l-carnitine on force development of the latissimus dorsi muscle in dogs. J Cardiac Surg 1991;6:270-275.
19. Hülsmann WC, Dubelaar ML: Aspects of fatty acid metabolism in vascular endothelial cells. Biochimie 1988;70:681-686.
20. Hülsmann WC, Dubelaar ML: Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia. Mol Cell Biochem 1992;116:125-129.
21. Giamberadino MA, Dragani L, Valente R, DiLisa F, Saggini R, Vecchiet L: Effects of prolonged l-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sport Med 1996;17:320-324.
22. Kraemer WJ, Volek JS, Dunn-Lewis C: l-Carnitine supplementation: influence upon physiological function. Curr Sports Med Rep 2008;7:218-223.
23. Kraemer WJ, Volek JS, Spiering BA, Vingren JL: l-Carnitine supplementation: a new paradigm for its role in exercise. Monatsh Chem 2005;136:1383-1390.
24. Volek JS, Judelson DA, Silvestre R, Yamamoto LM, Spiering BA, Hatfield DL, Vingren JL, Quann EE, Anderson JM, Maresh CM, Kraemer WJ: Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high fat meal in healthy young adults. Am J Cardiol 2008; 102:1413-1417.
25. Volek JS, Kraemer WJ, Rubin MR, Gomez AL, Ratamess NA, Gaynor P: l-Carnitine l-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physiol Endocrinol Metab 2002;282:E474-E482.
26. Ho J-Y, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, Coday M, Häkkinen K, Maresh CM: l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism 2010;59:1190-1199.
27. Spiering BA, Kraemer WJ, Hatfield DL, Vingren JL, Fragala MS, Ho J-Y, Thomas GA, Häkkinen K, Volek JS: Effects of l-carnitine l-tartrate supplementation on muscle oxygenation responses to resistance exercise. J Strength Cond Res 2008;22: 1130-1135.
28. Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gomez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Häkkinen K: The effects of l-carnitine l-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond Res 2003;17:455-462.
29. Inoue K, Yamasaki S, Fushiki T, Okada Y, Sugimoto E: Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle. Eur J Appl Physiol Occup Physiol 1994;69:88-91.
30. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Deschenes MR, Maresh CM: Androgenic responses to resistance exercise: effects of feeding and l-carnitine. Med Sci Sport Exer 2006;38:1288-1296.
31. Spiering BA, Kraemer WJ, Vingren JL, Hatfield DL, Fragala MS, Ho J-Y, Maresh CM, Anderson JM, Volek JS: Responses of criterion variables to different supplemental doses of l-carnitine l-tartrate. J Strength Cond Res 2007;21:259-264.
32. Rubin MR, Volek JS, Gomez AL, Ratamess NA, French DN, Sharman MJ, Kraemer WJ: Safety measures of l-carnitine l-tartrate supplementation in healthy men. J Strength Cond Res 2001;15:486-490.
33. European Food Safety Authority: Opinion of the scientific panel on food additives, flavorings, processing aids, and materials in contact with food (AFC) on request from the Commission related to l-carnitine l-tartrate for use in foods for particular nutritional uses. EFSA J 2003;19:1-13.