Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: Generation of antibodies against the thrombin-sensitive region of murine protein S

Journal of the American Chemical Society

Volumn 134, Issue 47, 2012, Pages 19318-19321

  Van De Vijver, Pieter ^a   Schmitt, Martin ^a,c,d   Suylen, Dennis ^a   Scheer, Liesbeth ^a   Thomassen, M C L G D ^a   Schurgers, Leon J ^a   Griffin, John H ^b   Koenen, Rory R ^a,c,d   Hackeng, Tilman M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENIC PEPTIDES; FOLDED PROTEINS; LOOP REGIONS; MULTIPLE ANTIGENIC PEPTIDE; MURINE PROTEINS; NATIVE CONFORMATION;

ANTIBODIES; ENZYMES; PEPTIDES;

ANTIGENS;

ANTIBODY; DISULFIDE; MULTIPLE ANTIGENIC PEPTIDE; PEPTIDE; PROTEIN S; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; CONJUGATION; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOGENICITY; ISOMERIZATION; PROTEIN FOLDING;

ANIMALS; ANTIBODIES; ANTIGENS; DISULFIDES; MICE; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; PROTEIN S; THROMBIN;

EID: 84870357551     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja306993t     Document Type: Article

References (15)

1. Heegaard, P. M. H.; Boas, U.; Sorensen, N. S. Bioconjug. Chem. 2009, 21, 405
2. Oliveira, E. D.; Villen, J.; Giralt, E.; Andreu, D. Bioconjug. Chem. 2003, 14, 144
3. Castoldi, E.; Hackeng, T. Curr. Opin. Hematol. 2008, 15, 529-536
4. Hackeng, T. M.; Fernandez, J. A.; Dawson, P. E.; Kent, S. B.; Griffin, J. H. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 14074
5. Hackeng, T. M.; Hessing, M.; van t Veer, C.; Meijer-Huizinga, F.; Meijers, J. C.; de Groot, P. G.; van Mourik, J. A.; Bouma, B. N. J. Biol. Chem. 1993, 268, 3993-4000
6. Fernández, J. A.; Heeb, M. J.; Xu, X.; Singh, I.; Zlokovic, B. V.; Griffin, J. H. Haematologica 2009, 94, 1721
7. Jiang, C.; Xiong, W.; Lu, B.; Gonda, M. A.; Chang, J. Biochemistry 2010, 49, 6550
8. Dawson, P. E.; Muir, T. W.; Clark-Lewis, I.; Kent, S. B. H. Science 1994, 266, 766-779
9. Saller, F.; Brisset, A. C.; Tchaikovski, S. N.; Azevedo, M.; Chrast, R.; Fernández, J. A.; Schapira, M.; Hackeng, T. M.; Griffin, J. H.; Angelillo-Scherrer, A. Blood 2009, 114, 2307-2314
10. Tchaikovski, S. N.; Vlijmen, B. J. M. V.; Rosing, J.; Tans, G. J. Thromb. Haemost. 2007, 5, 2079-2086
11. Seré, K. M.; Rosing, J.; Hackeng, T. M. Blood 2004, 104, 3624-3630
12. Van de Vijver, P.; Suylen, D.; Dirksen, A.; Dawson, P. E.; Hackeng, T. M. Biopolymers 2010, 94, 465
13. Dombkowski, A. A. Bioinformatics 2003, 19, 1852
14. Pellequer, J.; Chen, S. W. Proteins 2006, 65, 192
15. Nguyen, D. P.; Elliott, T.; Holt, M.; Muir, T. W.; Chin, J. W. J. Am. Chem. Soc. 2011, 133, 11418