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Volumn 108, Issue 2, 2012, Pages 338-348

The extent of P2Y12 inhibition by clopidogrel in diabetes mellitus patients with acute coronary syndrome is not related to glycaemic control: Roles of white blood cell count and body weight

Author keywords

Acute coronary syndrome; Inflammation; Leukocyte; Obesity; Platelet; Resistance; Stent thrombosis; Thienopyridines

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRINOGEN RECEPTOR ANTAGONIST; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; PROTON PUMP INHIBITOR; PURINERGIC P2Y12 RECEPTOR; THIENOPYRIDINE DERIVATIVE; TROPONIN I; VASODILATOR STIMULATED PHOSPHOPROTEIN; DRUG DERIVATIVE; GLYCOSYLATED HEMOGLOBIN; PURINERGIC P2Y RECEPTOR ANTAGONIST; TICLOPIDINE;

EID: 84870353178     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-12-0876     Document Type: Article
Times cited : (23)

References (45)
  • 1
    • 65349185008 scopus 로고    scopus 로고
    • Antiplatelet therapy in diabetes: Efficacy and limitations of current treatment strategies and future directions
    • Angiolillo D.J. Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directions. Diabetes Care 2009; 32: 531-540.
    • (2009) Diabetes Care , vol.32 , pp. 531-540
    • Angiolillo, D.J.1
  • 2
    • 34948875324 scopus 로고    scopus 로고
    • Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease
    • Angiolillo D J, Bernardo E, Sabate M, et al. Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 2007; 50:1541-1547.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1541-1547
    • Angiolillo, D.J.1    Bernardo, E.2    Sabate, M.3
  • 3
    • 79960728693 scopus 로고    scopus 로고
    • Impaired inhibition of P2Y(12) by clopidogrel is a major determinant of cardiac death in diabetes mellitus patients treated by percutaneous coronary intervention
    • El G.S, Ohlmann P, Jesel L, et al. Impaired inhibition of P2Y(12) by clopidogrel is a major determinant of cardiac death in diabetes mellitus patients treated by percutaneous coronary intervention. Atherosclerosis 2011; 217: 465-472.
    • (2011) Atherosclerosis , vol.217 , pp. 465-472
    • El, G.S.1    Ohlmann, P.2    Jesel, L.3
  • 4
    • 78649649127 scopus 로고    scopus 로고
    • Impact of inflammatory state and metabolic control on responsiveness to dual antiplatelet therapy in type 2 diabetics after PCI: Prognostic relevance of residual platelet aggregability in diabetics undergoing coronary interventions
    • Geisler T, Mueller K, Aichele S, et al. Impact of inflammatory state and metabolic control on responsiveness to dual antiplatelet therapy in type 2 diabetics after PCI: prognostic relevance of residual platelet aggregability in diabetics undergoing coronary interventions. Clin Res Cardiol 2010; 99: 743-752.
    • (2010) Clin Res Cardiol , vol.99 , pp. 743-752
    • Geisler, T.1    Mueller, K.2    Aichele, S.3
  • 5
    • 33846656039 scopus 로고    scopus 로고
    • Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation
    • Geisler T, Anders N, PaterokM, et al. Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation. Diabetes Care 2007; 30: 372-374.
    • (2007) Diabetes Care , vol.30 , pp. 372-374
    • Geisler, T.1    Anders, N.2    Paterok, M.3
  • 6
    • 77956379970 scopus 로고    scopus 로고
    • Diabetes and the platelet: Toward new therapeutic paradigms for diabetic atherothrombosis
    • Morel O, Kessler L, Ohlmann P, Bareiss P. Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosis. Atherosclerosis 2010; 212: 367-376.
    • (2010) Atherosclerosis , vol.212 , pp. 367-376
    • Morel, O.1
  • 7
    • 33644870179 scopus 로고    scopus 로고
    • Platelet inhibition by insulin is absent in type 2 diabetes mellitus
    • Ferreira IA, Mocking A, Feijge MA, et al. Platelet inhibition by insulin is absent in type 2 diabetes mellitus. Arterioscler Thromb Vase Biol 2006; 26:417-422.
    • (2006) Arterioscler Thromb Vase Biol , vol.26 , pp. 417-422
    • Ferreira, I.A.1    Mocking, A.2    Feijge, M.A.3
  • 8
    • 56849130022 scopus 로고    scopus 로고
    • Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo
    • Erlinge D, Varenhorst C, Braun OO, et al. Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo. J Am Coll Cardiol 2008; 52:1968-1977.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1968-1977
    • Erlinge, D.1    Varenhorst, C.2    Braun, O.O.3
  • 9
    • 84857749223 scopus 로고    scopus 로고
    • Vasodilator-stimulated phosphopro-tein-phosphorylation assay in patients on clopidogrel: Does standardisation matter?
    • Freynhofer MK, Bruno V, Willheim M, et al. Vasodilator-stimulated phosphopro-tein-phosphorylation assay in patients on clopidogrel: Does standardisation matter? Thromb Haemost 2012; 107: 538-544.
    • (2012) Thromb Haemost , vol.107 , pp. 538-544
    • Freynhofer, M.K.1    Bruno, V.2    Willheim, M.3
  • 10
    • 15944383861 scopus 로고    scopus 로고
    • Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases
    • Aleil B, Ravanat C, Cazenave JP, et al. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005; 3: 85-92.
    • (2005) J Thromb Haemost , vol.3 , pp. 85-92
    • Aleil, B.1    Ravanat, C.2    Cazenave, J.P.3
  • 11
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    • Bonello L, Tantry US, Marcucci R, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol 2010; 56: 919-933.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 919-933
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3
  • 12
    • 78049417758 scopus 로고    scopus 로고
    • Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: A prospective registry
    • El G.S, Ohlmann P, Meyer N, et al. Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: a prospective registry. JACC Cardiovasc Interv 2010; 3: 648-656.
    • (2010) JACC Cardiovasc Interv , vol.3 , pp. 648-656
    • El, G.S.1    Ohlmann, P.2    Meyer, N.3
  • 13
    • 79961046361 scopus 로고    scopus 로고
    • Multiple electrode aggregometry and vasodilator stimulated phosphoprotein-phosphorylation assay in clinical routine for prediction of postprocedural major adverse cardiovascular events
    • Freynhofer MK, Brozovic I, Bruno V, et al. Multiple electrode aggregometry and vasodilator stimulated phosphoprotein-phosphorylation assay in clinical routine for prediction of postprocedural major adverse cardiovascular events. Thromb Haemost 2011; 106: 230-239.
    • (2011) Thromb Haemost , vol.106 , pp. 230-239
    • Freynhofer, M.K.1    Brozovic, I.2    Bruno, V.3
  • 14
    • 78751605846 scopus 로고    scopus 로고
    • Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel
    • Morel O, El G.S, Jesel L, et al. Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel. J Am Coll Cardiol 2011; 57: 399-408.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 399-408
    • Morel, O.1    El, G.S.2    Jesel, L.3
  • 15
    • 33745815689 scopus 로고    scopus 로고
    • Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment
    • Angiolillo D J, Bernardo E, Ramirez C, et al. Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment. J Am Coll Cardiol 2006; 48: 298-304.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 298-304
    • Angiolillo, D.J.1    Bernardo, E.2    Ramirez, C.3
  • 16
    • 23644433510 scopus 로고    scopus 로고
    • Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 2005; 54: 2430-2435.
    • (2005) Diabetes , vol.54 , pp. 2430-2435
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 17
    • 77955886996 scopus 로고    scopus 로고
    • Comparison of platelet reactivity and peri-procedural outcomes in patients with versus without diabetes mellitus and treated with clopidogrel and percutaneous coronary intervention
    • Mangiacapra F, Patti G, Peace A, et al. Comparison of platelet reactivity and peri-procedural outcomes in patients with versus without diabetes mellitus and treated with clopidogrel and percutaneous coronary intervention. Am J Cardiol 2010;106:619-623.
    • (2010) Am J Cardiol , vol.106 , pp. 619-623
    • Mangiacapra, F.1    Patti, G.2    Peace, A.3
  • 18
    • 46749087824 scopus 로고    scopus 로고
    • Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease
    • Serebruany V, Pokov I, Kuliczkowski W, et al. Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease. Thromb Haemost 2008; 100: 76-82.
    • (2008) Thromb Haemost , vol.100 , pp. 76-82
    • Serebruany, V.1    Pokov, I.2    Kuliczkowski, W.3
  • 19
    • 0942276398 scopus 로고    scopus 로고
    • IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi
    • Ferreira IA, Eybrechts KL, Mocking Al, Kroner C, Akkerman JW. IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi. J Biol Chem 2004; 279: 3254-3264.
    • (2004) J Biol Chem , vol.279 , pp. 3254-3264
    • Ferreira, I.A.1    Eybrechts, K.L.2    Mocking, A.L.3    Kroner, C.4    Akkerman, J.W.5
  • 20
    • 70350056868 scopus 로고    scopus 로고
    • The relation between platelet reactivity and glycemic control in diabetic patients with cardiovascular disease on maintenance aspirin and clopidogrel therapy
    • Singla A, Antonino MJ, Bliden KP, et al. The relation between platelet reactivity and glycemic control in diabetic patients with cardiovascular disease on maintenance aspirin and clopidogrel therapy. Am Heart J 2009; 158: el-6.
    • (2009) Am Heart J , vol.158
    • Singla, A.1    Antonino, M.J.2    Bliden, K.P.3
  • 21
    • 79955155110 scopus 로고    scopus 로고
    • Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndromes. Results of the CHIPS Study ("Control de Hiperglucemia y Actividad Plaquetaria en Pacientes conSindrome Coronario Agudo)
    • Vivas D, Garcia-Rubira JC, Bernardo E, et al. Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndromes. Results of the CHIPS Study ("Control de Hiperglucemia y Actividad Plaquetaria en Pacientes conSindrome Coronario Agudo). Heart 2011; 97: 803-809.
    • (2011) Heart , vol.97 , pp. 803-809
    • Vivas, D.1    Garcia-Rubira, J.C.2    Bernardo, E.3
  • 22
    • 70449442585 scopus 로고    scopus 로고
    • Enhanced post-clopidogrel platelet reactivity in diabetic patients is independently related to plasma fibrinogen level but not to glycemic control
    • Gaborit B, Frere C, Cuisset T, et al. Enhanced post-clopidogrel platelet reactivity in diabetic patients is independently related to plasma fibrinogen level but not to glycemic control. J Thromb Haemost 2009; 7: 1939-1941.
    • (2009) J Thromb Haemost , vol.7 , pp. 1939-1941
    • Gaborit, B.1    Frere, C.2    Cuisset, T.3
  • 23
    • 58949088841 scopus 로고    scopus 로고
    • Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response
    • Cuisset T, Frere C, Quilici J, et al. Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response. Thromb Res 2009; 123: 597-603.
    • (2009) Thromb Res , vol.123 , pp. 597-603
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 24
    • 34447274446 scopus 로고    scopus 로고
    • Impact of body mass index on platelet aggregation after administration of a high loading dose of 600 mg of clopidogrel before percutaneous coronary intervention
    • Sibbing D, von Beckerath O, Schomig A, et al. Impact of body mass index on platelet aggregation after administration of a high loading dose of 600 mg of clopidogrel before percutaneous coronary intervention. Am J Cardiol 2007; 100: 203-205.
    • (2007) Am J Cardiol , vol.100 , pp. 203-205
    • Sibbing, D.1    von Beckerath, O.2    Schomig, A.3
  • 25
    • 77952764315 scopus 로고    scopus 로고
    • Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes
    • Diehl P, Olivier C, Halscheid C, et al. Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes. Basic Res Cardiol 2010; 105: 379-387.
    • (2010) Basic Res Cardiol , vol.105 , pp. 379-387
    • Diehl, P.1    Olivier, C.2    Halscheid, C.3
  • 26
    • 11144355993 scopus 로고    scopus 로고
    • Platelet aggregation according to body mass index in patients undergoing coronary stenting: Should clopidogrel loading-dose be weight adjusted?
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted? J Invasive Cardiol 2004; 16:169-174.
    • (2004) J Invasive Cardiol , vol.16 , pp. 169-174
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 27
    • 33750479499 scopus 로고    scopus 로고
    • Impact of the degree of peri-inter-ventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement
    • Hochholzer W, Trenk D, Bestehorn HP, et al. Impact of the degree of peri-inter-ventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol 2006; 48: 1742-1750.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1742-1750
    • Hochholzer, W.1    Trenk, D.2    Bestehorn, H.P.3
  • 28
    • 64849092007 scopus 로고    scopus 로고
    • The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease
    • Mak KH, Bhatt DL, Shao M, et al. The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease. Eur Heart J 2009; 30: 857-865.
    • (2009) Eur Heart J , vol.30 , pp. 857-865
    • Mak, K.H.1    Bhatt, D.L.2    Shao, M.3
  • 29
    • 51449092037 scopus 로고    scopus 로고
    • What makes platelets angry: Diabetes, fibrinogen, obesity, and impaired response to antiplatelet therapy?
    • Bhatt DL. What makes platelets angry: diabetes, fibrinogen, obesity, and impaired response to antiplatelet therapy? J Am Coll Cardiol 2008; 52:1060-1061.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1060-1061
    • Bhatt, D.L.1
  • 30
    • 84856482031 scopus 로고    scopus 로고
    • Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles
    • Morel O, Luca F, Grunebaum L, et al. Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles. Int J Obes 2011; 35:1479-1486.
    • (2011) Int J Obes , vol.35 , pp. 1479-1486
    • Morel, O.1    Luca, F.2    Grunebaum, L.3
  • 31
    • 51449118219 scopus 로고    scopus 로고
    • Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel
    • Ang L, Palakodeti V, Khalid A, et al. Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel. J Am Coll Cardiol 2008; 52:1052-1059.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1052-1059
    • Ang, L.1    Palakodeti, V.2    Khalid, A.3
  • 32
    • 79961045655 scopus 로고    scopus 로고
    • The relationship between platelet reactivity and infarct-related artery patency in patients presenting with a ST-elev-ation myocardial infarction
    • Breet NJ, van Werkum JW, Bouman HJ, et al. The relationship between platelet reactivity and infarct-related artery patency in patients presenting with a ST-elev-ation myocardial infarction. Thromb Haemost 2011; 106: 331-336.
    • (2011) Thromb Haemost , vol.106 , pp. 331-336
    • Breet, N.J.1    van Werkum, J.W.2    Bouman, H.J.3
  • 33
    • 0035075438 scopus 로고    scopus 로고
    • Platelet CD40 ligand (CD40L)-subcellu-lar localization, regulation of expression, and inhibition by clopidogrel
    • Hermann A, Rauch BH, Braun M, et al. Platelet CD40 ligand (CD40L)-subcellu-lar localization, regulation of expression, and inhibition by clopidogrel. Platelets 2001;12:74-82.
    • (2001) Platelets , vol.12 , pp. 74-82
    • Hermann, A.1    Rauch, B.H.2    Braun, M.3
  • 34
    • 33644775853 scopus 로고    scopus 로고
    • Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease. Diabetes 2006; 55: 780-784.
    • (2006) Diabetes , vol.55 , pp. 780-784
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 35
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter G, Jantzen HM, Vincent D, et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001; 409:202-207.
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1    Jantzen, H.M.2    Vincent, D.3
  • 36
    • 2142716833 scopus 로고    scopus 로고
    • Leukocyte count as an independent predictor of recurrent ischemic events
    • Grau AJ, Boddy AW, Dukovic DA, et al. Leukocyte count as an independent predictor of recurrent ischemic events. Stroke 2004; 35:1147-1152.
    • (2004) Stroke , vol.35 , pp. 1147-1152
    • Grau, A.J.1    Boddy, A.W.2    Dukovic, D.A.3
  • 37
    • 45349096765 scopus 로고    scopus 로고
    • Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST-elevation myocardial infarction receiving fibrinolytic therapy
    • O'Donoghue M, Morrow DA, Cannon CP, et al. Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST-elevation myocardial infarction receiving fibrinolytic therapy. Eur Heart J 2008; 29: 984-991.
    • (2008) Eur Heart J , vol.29 , pp. 984-991
    • O'Donoghue, M.1    Morrow, D.A.2    Cannon, C.P.3
  • 38
    • 34247869852 scopus 로고    scopus 로고
    • Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial
    • Bhatt DL, Flather MD, Hacke W, et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol 2007; 49: 1982-1988.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1982-1988
    • Bhatt, D.L.1    Flather, M.D.2    Hacke, W.3
  • 39
    • 79952818885 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein and clopidogrel treatment in patients at high risk of cardiovascular events: A substudy from the CHARISMA trial
    • Weber M, Bhatt DL, Brennan DM, et al. High-sensitivity C-reactive protein and clopidogrel treatment in patients at high risk of cardiovascular events: a substudy from the CHARISMA trial. Heart 2011; 97: 626-631.
    • (2011) Heart , vol.97 , pp. 626-631
    • Weber, M.1    Bhatt, D.L.2    Brennan, D.M.3
  • 40
    • 55949103494 scopus 로고    scopus 로고
    • Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38
    • Wiviott SD, Braunwald E, Angiolillo DJ, et al. Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38. Circulation 2008;118:1626-1636.
    • (2008) Circulation , vol.118 , pp. 1626-1636
    • Wiviott, S.D.1    Braunwald, E.2    Angiolillo, D.J.3
  • 41
    • 70349443275 scopus 로고    scopus 로고
    • Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: Results from the HORIZONS-AMI (harmonizing outcomes with rev-ascularization and stents in acute myocardial infarction) trial
    • Dangas G, Mehran R, Guagliumi G, et al. Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: results from the HORIZONS-AMI (harmonizing outcomes with rev-ascularization and stents in acute myocardial infarction) trial. J Am Coll Cardiol 2009; 54: 1438-1446.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1438-1446
    • Dangas, G.1    Mehran, R.2    Guagliumi, G.3
  • 42
    • 49249137412 scopus 로고    scopus 로고
    • Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction
    • Heestermans AA, van Werkum JW, Taubert D, et al. Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction. Thromb Res 2008; 122: 776-781.
    • (2008) Thromb Res , vol.122 , pp. 776-781
    • Heestermans, A.A.1    van Werkum, J.W.2    Taubert, D.3
  • 43
    • 80053321770 scopus 로고    scopus 로고
    • Outcome comparison of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Results from the ARMYDA-6 MI (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Myocardial Infarction) randomized study
    • Patti G, Barczi G, Orlie D, et al. Outcome comparison of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: results from the ARMYDA-6 MI (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Myocardial Infarction) randomized study. J Am Coll Cardiol 2011;58:1592-1599.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 1592-1599
    • Patti, G.1    Barczi, G.2    Orlie, D.3
  • 44
    • 79851480679 scopus 로고    scopus 로고
    • High versus standard clopidogrel maintenance dose after percutaneous coronary intervention and effects on platelet inhibition, endothelial function, and inflammation results of the ARMYDA-150 mg (antiplatelet therapy for reduction of myocardial damage during angioplasty) randomized study
    • Patti G, Grieco D, Dicuonzo G, et al. High versus standard clopidogrel maintenance dose after percutaneous coronary intervention and effects on platelet inhibition, endothelial function, and inflammation results of the ARMYDA-150 mg (antiplatelet therapy for reduction of myocardial damage during angioplasty) randomized study. J Am Coll Cardiol 2011; 57: 771-778.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 771-778
    • Patti, G.1    Grieco, D.2    Dicuonzo, G.3
  • 45
    • 82955201639 scopus 로고    scopus 로고
    • Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction
    • Dorler J, Edlinger M, Alber HF, et al. Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction. Eur Heart J 2011; 32: 2954-2961.
    • (2011) Eur Heart J , vol.32 , pp. 2954-2961
    • Dorler, J.1    Edlinger, M.2    Alber, H.F.3


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