Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction

Thrombosis Research

Volumn 122, Issue 6, 2008, Pages 776-781

  Heestermans, Antonius A C M ^a   van Werkum, Jochem W ^a   Taubert, Dirk ^b   Seesing, Toine H ^a   von Beckerath, Nicolas ^c   Hackeng, Christian M ^a   Schömig, Edgar ^b   Verheugt, F W A ^d   ten Berg, Jurriën M ^a  

^a ST ANTONIUS HOSPITAL   (Netherlands)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UMC Nijmegen   (Netherlands)

Author keywords

Clopidogrel; Pharmacokinetics; Platelets; ST segment elevation Myocardial Infarction

Indexed keywords

ABCIXIMAB; CLOPIDOGREL; HEPARIN; LYSINE ACETYLSALICYLATE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; HEART INFARCTION; HUMAN; LOADING DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL; ST SEGMENT ELEVATION; THROMBOCYTE AGGREGATION;

ADULT; AGED; BIOLOGICAL AVAILABILITY; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE;

EID: 49249137412     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.01.021     Document Type: Article

References (24)

1. Sabatine M.S., Cannon C.P., Gibson C.M., López-Sendón J.L., Montalescot G., Theroux P., et al. Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study. JAMA 294 (2005) 1224-1232
2. Steinhubl S.R., Berger P.B., Mann III J.T., Fry E.T., DeLago A., Wilmer C., et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 288 (2002) 2411-2420
3. Mehta S.R., Yusuf S., Peters R.J., Bertrand M.E., Lewis B.S., Natarajan M.K., et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358 (2001) 527-533
4. Chen Z.M., Jiang L.X., Chen Y.P., Xie J.X., Pan H.C., Peto R., et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 366 (2005) 1607-1621
5. Gurbel P.A., Bliden K.P., Hayes K.M., Yoho J.A., Herzog W.R., and Tantry U.S. The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol 45 (2005) 1392-1396
6. Gurbel P.A., Bliden K.P., Hiatt B.L., and O'Connor C.M. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 107 (2003) 2908-2913
7. Angiolillo D.J., Fernández-Ortiz A., Bernardo E., Ramírez C., Sabaté M., Bañuelos C., et al. High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability. Eur Heart J 25 (2004) 1903-1910
8. Serebruany V.L., Steinhubl S.R., Berger P.B., Malinin A.I., Bhatt D.L., and Topol E.J. Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 45 (2005) 246-251
9. van Werkum J.W., Heestermans A.A.C.M., Deneer V.H.M., Hackeng C.M., and Ten Berg J.M. Clopidogrel resistance: Fact and Fiction. Futur Cardiol 2 (2006) 215-228
10. Taubert D., Kastrati A., Harlfinger S., Gorchakova O., Lazar A., von Beckerath N., et al. Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb Haemost 92 (2004) 311-316
11. von Beckerath N., Taubert D., Pogatsa-Murray G., Schömig E., Kastrati A., and Schömig A. Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation 112 (2005) 2946-2950
12. Bailey R.W., Bulkley G.B., Hamilton S.R., Morris J.B., and Haglund U.H. Protection of the small intestine from nonocclusive mesenteric ischemic injury due to cardiogenic shock. Am J Surg 153 (1987) 108-116
13. Cappell M.S. Intestinal (mesenteric) vasculopathy. II. Ischemic colitis and chronic mesenteric ischemia. Gastroenterol Clin North Am 27 (1998) 827-860
14. Bassiouny H.S. Nonocclusive mesenteric ischemia. Surg Clin North Am 77 (1997) 319-326
15. Levin E.R., Gardner D.G., and Samson W.K. Natriuretic peptides. N Engl J Med 339 (1998) 321-328
16. Schrier R.W., and Abraham W.T. Hormones and hemodynamics in heart failure. N Engl J Med 341 (1999) 577-585
17. Blandizzi C., Agen C., Natale G., and Del Tacca M. Atrial natriuretic peptide inhibits the spontaneous contractions of rabbit isolated ileum. J Pharm Pharmacol 44 (1992) 615-617
18. Catto-Smith A.G., Hardin J.A., Patrick M.K., O'Loughlin E.V., and Gall D.G. The effect of atrial natriuretic peptide on intestinal electrolyte transport. Regul Pept 36 (1991) 29-44
19. Scott R.B., and Maric M. The effect of atrial natriuretic peptide on small intestinal contractility and transit. Peptides 12 (1991) 799-803
20. McCann M.J., Nice-Lepard K., and Rogers R.C. Dorsal medullary injection of atrial natriuretic factor (ANF) excites vagal efferents and inhibits gastric motility. Brain Res 549 (1991) 247-252
21. Gawaz M., Neumann F.J., Ott I., Schiessler A., and Schömig A. Platelet function in acute myocardial infarction treated with direct angioplasty. Circulation 93 (1996) 229-237
22. Gurbel P.A., Samara W.M., and Bliden K.P. Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis. Platelets 15 (2004) 95-99
23. Hochholzer W., Trenk D., Frundi D., Blanke P., Fischer B., Andris K., et al. Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention. Circulation 111 (2005) 2560-2564
24. Müller I., Seyfarth M., Rüdiger S., Wolf B., Pogatsa-Murray G., Schömig A., et al. Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement. Heart 85 (2001) 92-93