Murine tumor necrosis factor α-induced adipose-related protein (tumor necrosis factor α-induced protein 9) deficiency leads to arthritis via interleukin-6 overproduction with enhanced NF-κB, STAT-3 signaling, and dysregulated apoptosis of macrophages

Arthritis and Rheumatism

Volumn 64, Issue 12, 2012, Pages 3877-3885

  Inoue, Asuka ^a   Matsumoto, Isao ^a   Tanaka, Yoko ^a   Umeda, Naoto ^a   Tanaka, Yuki ^a   Mihara, Masahiko ^b   Takahashi, Satoru ^a   Sumida, Takayuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; COLLAGEN; COLLAGEN TYPE 2; COLLAGEN TYPE 2 ANTIBODY; COLLAGEN TYPE 2 RECEPTOR MONOCLONAL ANTIBODY; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; MR 161; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 9; TUMOR NECROSIS FACTOR ALPHA INDUCED RELATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTHRITIS; ARTICLE; CELL COUNT; CELL CULTURE; CELL ISOLATION; CYTOKINE PRODUCTION; GENE DELETION; IMMUNE RESPONSE; LYMPH NODE; MACROPHAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPLEEN CELL; SYNOVITIS; TH1 CELL; TH17 CELL;

ANIMALS; APOPTOSIS; ARTHRITIS; ARTHRITIS, EXPERIMENTAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; INTERLEUKIN-6; MACROPHAGES, PERITONEAL; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TH1 CELLS; TH17 CELLS;

EID: 84870334913     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34666     Document Type: Article

References (24)

1. Taylor PC, Feldmann M,. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol 2009; 5: 578-82.
2. Mima T, Nishimoto N,. Clinical value of blocking IL-6 receptor. Curr Opin Rheumatol 2009; 21: 224-30.
3. Matsumoto I, Staub A, Benoist C, Mathis D,. Arthritis provoked by linked T and B recognition of a glycolytic enzyme. Science 1999; 286: 1732-5. (Pubitemid 129515879)
4. Schubert D, Maier B, Morawietz L, Krenn V, Kamradt T,. Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol 2004; 172: 4503-9. (Pubitemid 38375267)
5. Matsumoto I, Zhang H, Yasukochi T, Iwanami K, Tanaka Y, Inoue A, et al. Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis. Arthritis Res Ther 2008; 10: R66.
6. Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, et al. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum 2008; 58: 754-63. (Pubitemid 351364873)
7. Inoue A, Matsumoto I, Tanaka Y, Iwanami K, Kanamori A, Ochiai N, et al. Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis. Arthritis Res Ther 2009; 11: R118.
8. Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Umeda N, Tanaka Y, et al. Six-transmembrane epithelial antigen of prostate 4 (STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis. Clin Exp Rheumatol 2012; 30: 99-102.
9. Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, et al. Coordinated regulation of nutrient and inflammatory response by STAMP2 is essential for metabolic homeostasis. Cell 2007; 129: 537-48. (Pubitemid 46660973)
10. Takagi N, Mihara M, Moriya Y, Nishimoto N, Yoshizaki K, Kishimoto T, et al. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum 1998; 41: 2117-21. (Pubitemid 29009369)
11. Moldes M, Lasnier F, Gauthereau X, Klein C, Pairault J, Feve B, et al. Tumor necrosis factor-α-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-α and adipose conversion. J Biol Chem 2001; 276: 33938-46.
12. Fasshauer M, Kralisch M, Klier M, Lossner U, Bluher M, Chambaut-Guerin AM, et al. Interleukin-6 is a positive regulator of tumor necrosis factor α-induced adipose-related protein in 3T3-L1 adipocytes. FEBS Lett 2004; 560: 153-7. (Pubitemid 38264310)
13. Ohgami RS, Campagna DR, McDonald A, Fleming MD,. The Steap proteins are metalloreductases. Blood 2006; 108: 1388-94. (Pubitemid 44232042)
14. Sparna T, Retey J, Schmich K, Albrecht U, Naumann K, Gretz N, et al. Genome-wide comparison between IL-17 and combined TNF-α/IL-17 induced genes in primary murine hepatocytes. BMC Genomics 2010; 11: 226.
15. Ramadoss P, Chiappini F, Biban M, Hollenberg AN,. Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein α. J Biol Chem 2010; 285: 16453-66.
16. Wang ZH, Zhang W, Gong HP, Guo ZX, Zhao J, Shang YY, et al. Expression of STAMP2 in monocytes associates with cardiovascular alterations. Eur J Clin Invest 2010; 40: 490-6.
17. Waki H, Tontonoz P,. STAMPing out inflammation. Cell 2007; 129: 451-2. (Pubitemid 46660981)
18. Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007; 39: 1477-82. (Pubitemid 350191346)
19. Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, et al. Rheumatoid arthritis association at 6q23. Nat Genet 2007; 39: 1431-3. (Pubitemid 350191348)
20. Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, et al. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 2011; 43: 908-12.
21. Lally F, Smith E, Filer A, Stone MA, Shaw JS, Nash GB, et al. A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum 2005; 52: 3460-9. (Pubitemid 41612212)
22. Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med 2002; 196: 979-90.
23. Murakami M, Okuyama Y, Ogura H, Asano S, Arima Y, Tsuruoka M, et al. Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. J Exp Med 2011; 208: 103-14.
24. Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, et al. Six-transmembrane epithelial antigen of prostate 4 (STEAP4) is a tumor necrosis factor α-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis. Mod Rheumatol 2012; 22: 128-36.