Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 5159-5173

  Yang, Hung Wei ^a   Hua, Mu Yi ^a   Lin, Kun Ju ^b   Wey, Shiaw Pyng ^c   Tsai, Rung Ywan ^c   Wu, Siao Yun ^d   Lu, Yi Ching ^d   Liu, Hao Li ^d   Wu, Tony ^e   Ma, Yunn Hwa ^d  

^a Chang Gung Molecular Medicine Research Center   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Magnetic nanocarriers; Magnetic targeting; Recombinant tissue plasminogen activator; Targeting therapy; Thrombolysis

Indexed keywords

ALTEPLASE; AMIDE; MAGNETIC NANOPARTICLE; POLYACRYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCOMPATIBILITY; BLOOD CLOT LYSIS; BLOOD FLOW; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG STABILITY; DRUG TARGETING; EMBOLISM; FEASIBILITY STUDY; IN VITRO STUDY; MALE; NONHUMAN; PARTICLE SIZE; QUANTITATIVE ANALYSIS; RAT; TEMPERATURE DEPENDENCE; THERMOSTABILITY;

ANIMALS; BLOOD COAGULATION; FIBRINOLYTIC AGENTS; HUMANS; IMMUNOMAGNETIC SEPARATION; MAGNETITE NANOPARTICLES; MATERIALS TESTING; NANOCAPSULES; PROTEIN BINDING; RATS; TISSUE PLASMINOGEN ACTIVATOR;

RATTUS;

EID: 84870317399     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S32939     Document Type: Article

References (44)

1. Harpel PC, Chang TS, Verderber E. Tissue plasminogen activator and urokinase mediate the binding of Glu-plasminogen to plasma fibrin I. Evidence for new binding sites in plasmin-degraded fibrin I. J Biol Chem. 1985;260(7):4432-4440.
2. Marder VJ. Thrombolytic therapy: 2001. Blood Rev. 2001;15(3): 143-157.
3. Andersen HR, Nielsen TT, Rasmussen K, etal; for DANAMI-2 Investigators. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med. 2003;349(8): 733-742.
4. Madison EL, Coombs GS, Corey DR. Characterization of the fibrin independent specificity of t-PA for plasminogen. J Biol Chem. 1995; 270(13):7558-7562.
5. Hacke W, Kaste M, Fieschi C, etal. Randomized double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet. 1998;352(9136): 1245-1251.
6. Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5hours after symptom onset: The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA. 1999;282(21): 2019-2026.
7. Leach JK, O'Rear EA, Patterson E, Miao Y, Johnson AE. Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. Thromb Haemost. 2003;90(1):64-70.
8. Chung TW, Wang SS, Tsai WJ. Accelerating thrombolysis with chitosan-coated plasminogen activators encapsulated in poly-(lactide-co-glycolide) (PLGA) nanoparticles. Biomaterials. 2008;29(2): 228-237.
9. Ma YH, Wu SY, Wu T, Chang YJ, Hua MY, Chen JP. Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles. Biomaterials. 2009; 30(19):3343-3351.
10. Xie Y, Kaminski MD, Torno MD, Finck MR, Liu X, Rosengart AJ. Physicochemical characteristics of magnetic microspheres containing tissue plasminogen activator. J Magn Magn Mater. 2007;311(1): 376-378.
11. Bi F, Zhang J, Su Y, Tang YC, Liu JN. Chemical conjugation of urokinase to magnetic nanoparticles for targeted thrombolysis. Biomaterials. 2009;30(28):5125-5130.
12. Torno MD, Kaminski MD, Xie Y, etal. Improvement of in vitro thrombolysis employing magnetically-guided microspheres. Thromb Res. 2008;121(6):799-811.
13. Hong J, Xu D, Gong P, Yu J, Ma H, Yao S. Covalent-bonded immobilization of enzyme on hydrophilic polymer covering magnetic nanogels. Microporous Mesoporous Mater. 2008;109:470-477.
14. Dobson J. Magnetic nanoparticles for drug delivery. Drug Dev Res. 2006;67(1):55-60.
15. Horák D, Babic M, Macková H, Benes MJ. Preparation and properties of magnetic nano-and microsized particles for biological and environmental separations. J Sep Sci. 2007;30(11):1751-1772.
16. Gamarra LF, Brito GES, Pontuschka WM, Amaro E, Parma AHC, Goya GF. Biocompatible superparamagnetic iron oxide nanoparticles used for contrast agents: a structural and magnetic study. J Magn Magn Mater. 2005;289:439-441.
17. Cheng FY, Su CH, Yang YS, etal. Characterization of aqueous dispersions of Fe(3)O(4) nanoparticles and their biomedical applications. Biomaterials. 2005;26(7):729-738.
18. Hua MY, Yang HW, Liu HL, etal. Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy. Biomaterials. 2011;32(34):8999-9010.
19. Lee G, Kim J, Lee J-H. Development of magnetically separable polyaniline nanofibers for enzyme immobilization and recovery. Enzyme Microb Technol. 2008;42(6):466-472.
20. Lee D-G, Ponvel KM, Kim M, Hwang S, Ahn IS, Lee CH. Immobilization of lipase on hydrophobic nano-sized magnetite particles. J Mol Catal B Enzym. 2009;57(1-4):62-66.
21. Liberti PA, Rao CG, Terstappen LWMM. Optimization of ferrofluids and protocols for the enrichment of breast tumor cells in blood. J Magn Magn Mater. 2001;225(1-2):301-307.
22. Sonvico F, Mornet S, Vasseur S, etal. Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments. Bioconjug Chem. 2005; 16(5):1181-1188.
23. Kohler N, Sun C, Wang J, Zhang M. Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. Langmuir. 2005;21(19):8858-8864.
24. Zhang JL, Srivastava RS, Misra RD. Core-shell magnetite nanoparticles surface encapsulated with smart stimuli-responsive polymer: synthesis, characterization, and LCST of viable drug-targeting delivery system. Langmuir. 2007;23(11):6342-6351.
25. Zhang Y, Zhang J. Surface modification of monodisperse magnetite nanoparticles for improved intracellular uptake to breast cancer cells. J Colloid Interface Sci. 2005;283(2):352-357.
26. Hu F, Li Z, Tu C, Gao M. Preparation of magnetite nanocrystals with surface reactive moieties by one-pot reaction. J Colloid Interface Sci. 2007;311(2):469-474.
27. Hua MY, Yang HW, Chuang CK, etal. Magnetic-nanoparticle-modified paclitaxel for targeted therapy for prostate cancer. Biomaterials. 2010;31(28):7735-7763.
28. Hua MY, Liu HL, Yang HW, etal. The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas. Biomaterials. 2011;32(2):516-527.
29. Yang HW, Hua MY, Liu HL, etal. Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas. Biomaterials. 2011;32(27):6523-6532.
30. Fang N, Tan WJ, Leong KW, Mao HQ, Chan V. pH responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylene terephthalate) surface. Colloids Surf B Biointerfaces. 2005;42(3-4):245-252.
31. Kouassi GK, Irudayaraj J, McCarty G. Examination of cholesterol oxidase attachment to magnetic nanoparticles. J Nanobiotechnology. 2005;3(1):1.
32. Ye P, Xu ZK, Che AF, Wu J, Seta P. Chitosan-tethered poly(acrylonitrile-co-maleic acid) hollow fiber membrane for lipase immobilization. Biomaterials. 2005;26(32):6394-6403.
33. Ma YH, Hsu YW, Chang YJ, Hua MY, Chen JP, Wu T. Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy: a rat embolic model. J Magn Magn Mater. 2007;311(1):342-346.
34. Ma HL, Qi XR, Maitani Y, Nagai T. Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate. Int J Pharm. 2007;333(1-2):177-186.
35. Chen SA, Hwang GW. Water-soluble self-acid-doped conducting polyaniline: structure and properties. J Am Chem Soc. 1995;117(40): 10055-10062.
36. Luthra V, Singh R, Gupta SK, Mansingh A. Mechanism of dc conduction in polyaniline doped with sulfuric acid. Current Applied Physics. 2003;3(2-3):219-222.
37. Liao DL, Wu GS, Liao BQ. Zeta potential of shape-controlled TiO2 nanoparticles with surfactants. Colloids Surf A Physicochem Eng Asp. 2009;348(1-3):270-275.
38. Mandzy N, Grulke E, Druffel T. Breakage of TiO2 agglomerates in electrostatically stabilized aqueous dispersions. Powder Technol. 2005;160(2):121-126.
39. Zhang HZ, Gao FP, Liu LR, etal. Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy. Colloid Surf B Biointerfaces. 2009;71(1):19-26.
40. Wang YS, Liu LR, Jiang Q, Zhang QQ. Self-aggregated nanoparticles of cholesterol-modified chitosan conjugate as a novel carrier of epirubicin. Eur Polym J. 2007;43(1):43-51.
41. Li Y, Zhang Y, Yang D, etal. PAA-g-PPO amphiphilic graft copolymer: synthesis and diverse micellar morphologies. Macromolecules. 2010; 43(1):262-270.
42. Dessouki AM, Atia KS. Immobilization of adenosine deaminase onto agarose and casein. Biomacromolecules. 2002;3(3):432-437.
43. Hamm B, Staks T, Taupitz M, etal. Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide. J Magn Reson Imaging. 1994;4(5):659-668.
44. Iwasaka M, Takeuchi M, Ueno S, Tsuda H. Polymerization and dissolution of fibrin under homogeneous magnetic fields. J Appl Phys. 1998;83(11):6453-6455.