The nuclear localization of glycogen synthase kinase 3β is required its putative PY-nuclear localization sequences

Molecules and Cells

Volumn 34, Issue 4, 2012, Pages 375-382

  Shin, Sung Hwa ^a   Lee, Eun Jeoung ^a   Chun, Jaesun ^b   Hyun, Sunghee ^c   Kim, Youg Il ^a   Kang, Sang Sun ^a  

^a Chungbuk National University   (South Korea)

^b Korea National University of Education   (South Korea)

^c Eulji University School of Medicine   (South Korea)

Author keywords

GSK 3 ; Karyopherin 2; Protein protein interaction; PY NLS; Subcellular localization

Indexed keywords

ACTIN; ARGININE; GLYCOGEN SYNTHASE KINASE 3BETA; ISOLEUCINE; KARYOPHERIN BETA; KARYOPHERIN BETA2; LEUCINE; PHENYLALANINE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; CELL NUCLEUS; CELL STRAIN HEK293; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; MUTANT; MUTATION; NUCLEAR LOCALIZATION SIGNAL; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BETA KARYOPHERINS; CELL NUCLEUS; CELL SURVIVAL; ENZYME STABILITY; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; NUCLEAR LOCALIZATION SIGNALS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN TRANSPORT; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS;

EID: 84870317115     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-012-0167-2     Document Type: Article

References (32)

1. Bijur, G.N., and Jope, R.S. (2003). Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria. Neuroreport 14, 2415-2419.
2. Bonifaci, N., Moroianu, J., Radu, A., and Blobel, G. (1997). Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Proc. Natl. Acad. Sci. USA 94, 5055-5060.
3. Cole, A., Frame, S., and Cohen, P. (2004). Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event. Biochem. J. 377, 249-255.
4. Doble, B.W., and Woodgett, J.R. (2003). GSK-3: Tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116, 1175-1186.
5. Eun Jeoung, L., Sung Hee, H., Jaesun, C., Sung Hwa, S., Kwang Hum, Y., Min Kyoung, K., Tae Yoon, P., and Sang Sun, K. (2008). Regulation of glycogen synthase kinase 3beta functions by modification of the small ubiquitin-like modifier. Open Biochem. J. 2, 67-76.
6. Frame, S., Cohen, P., and Biondi, R.M. (2001). A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell 7, 1321-1327.
7. Fu, Y., Zheng, S., An, N., Athanasopoulos, T., Popplewell, L., Liang, A., Li, K., Hu, C., and Zhu, Y. (2011). beta-catenin as a potential key target for tumor suppression. Int. J. Cancer 129, 1541-1551.
8. Hongisto, V., Vainio, J.C., Thompson, R., Courtney, M.J., and Coffey, E.T. (2008). The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death. Mol. Cell. Biol. 28, 1515-1527.
9. Hoshi, M., Sato, M., Kondo, S., Takashima, A., Noguchi, K., Takahashi, M., Ishiguro, K., and Imahori, K. (1995). Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mito chondria. J. Biochem. 118, 683-685.
10. Hur, E.M., and Zhou, F.Q. (2010). GSK3 signalling in neural development. Nat. Rev. Neurosci. 11, 539-551.
11. Kikuchi, A. (1999). Roles of Axin in the Wnt signalling pathway. Cell Signal. 11, 777-788.
12. Ku, B.M., Lee, Y.K., Jeong, J.Y., Ryu, J., Choi, J., Kim, J.S., Cho, Y.W., Roh, G.S., Kim, H.J., Cho, G.J., et al. (2011). Caffeine inhibits cell proliferation and regulates PKA/GSK3beta pathways in U87MG human glioma cells. Mol. Cells 31, 275-279.
13. Kuo, C.W., Wang, W.H., and Liu, S.T. (2011). Mapping signals that are important for nuclear and nucleolar localization in MCRS2. Mol. Cells 31, 547-552.
14. Lange, A., Mills, R.E., Devine, S.E., and Corbett, A.H. (2008). A PYNLS nuclear targeting signal is required for nuclear localization and function of the Saccharomyces cerevisiae mRNA-binding protein Hrp1. J. Biol. Chem. 283, 12926-12934.
15. Lee, E.J., Shin, S.H., Hyun, S., Chun, J., and Kang, S.S. (2011). Mutation of a putative S-nitrosylation site of TRPV4 protein facilitates the channel activates. Animal Cells Syst. (Seoul) 15, 95-106.
16. Lustig, B., and Behrens, J. (2003). The Wnt signaling pathway and its role in tumor development. J. Cancer Res. Clin. Oncol. 129, 199-221.
17. Marfori, M., Mynott, A., Ellis, J.J., Mehdi, A.M., Saunders, N.F., Curmi, P.M., Forwood, J.K., Boden, M., and Kobe, B. (2011). Molecular basis for specificity of nuclear import and prediction of nuclear localization. Biochim. Biophys. Acta 1813, 1562-1577.
18. Meares, G.P., and Jope, R.S. (2007). Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: Functional effects in apoptosis. J. Biol. Chem. 282, 16989-17001.
19. Mishra, R. (2010). Glycogen synthase kinase 3 beta: Can it be a target for oral cancer. Mol. Cancer 9, 144.
20. Mo, Y.Y., Wang, C., and Beck, W.T. (2000). A novel nuclear localization signal in human DNA topoisomerase I. J. Biol. Chem. 275, 41107-41113.
21. Moule, S.K., Welsh, G.I., Edgell, N.J., Foulstone, E.J., Proud, C.G., and Denton, R.M. (1997). Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and-insensitive mechanisms. J. Biol. Chem. 272, 7713-7719.
22. Patel, S., Doble, B., and Woodgett, J.R. (2004). Glycogen synthase kinase-3 in insulin and Wnt signalling: A double-edged sword? Biochem. Soc. Trans. 32, 803-808.
23. Roberts, D.M., Pronobis, M.I., Poulton, J.S., Waldmann, J.D., Stephenson, E.M., Hanna, S., and Peifer, M. (2011). Deconstructing the sscatenin destruction complex: Mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol. Biol. Cell 22, 1845-1863.
24. Suel, K.E., Gu, H., and Chook, Y.M. (2008). Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals. PLoS Biol. 6, e137.
25. Sui, Z., Kovacs, A.D., and Maggirwar, S.B. (2006). Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts. Biochem. Biophys. Res. Commun. 345, 1643-1648.
26. Takeda, K., Haque, M., Nagoshi, E., Takemoto, M., Shimamoto, T., Yoneda, Y., and Yamanishi, K. (2000). Characterization of human herpesvirus 7 U27 gene product and identification of its nuclear localization signal. Virology 272, 394-401.
27. Tanioka, T., Tamura, Y., Fukaya, M., Shinozaki, S., Mao, J., Kim, M., Shimizu, N., Kitamura, T., and Kaneki, M. (2011). Inducible nitricoxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: Involvement of glycogen synthase kinase-3beta. J. Biol. Chem. 286, 29388-29396.
28. Topol, L., Chen, W., Song, H., Day, T.F., and Yang, Y. (2009). Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus. J. Biol. Chem. 284, 3323-3333.
29. Twomey, C., and McCarthy, J.V. (2006). Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate. FEBS Lett. 580, 4015-4020.
30. Xu, D., Farmer, A., and Chook, Y.M. (2010). Recognition of nuclear targeting signals by Karyopherin-beta proteins. Curr. Opin. Struct. Biol. 20, 782-790.
31. Yi, F., Pereira, L., Hoffman, J.A., Shy, B.R., Yuen, C.M., Liu, D.R., and Merrill, B.J. (2011). Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat. Cell Biol. 13, 762-770.
32. Zhai, P., Sciarretta, S., Galeotti, J., Volpe, M., and Sadoshima, J. (2011). Differential roles of GSK-3beta during myocardial ischemia and ischemia/reperfusion. Circ. Res. 109, 502-511.