Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: Role for glutathione-dependent metabolism of methylglyoxal

Free Radical Biology and Medicine

Volumn 54, Issue , 2013, Pages 51-61

  Li, Wei ^a   Maloney, Ronald E ^a   Circu, Magdalena L ^a   Alexander, J Steven ^a   Aw, Tak Yee ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Carbonyl stress; Cerebral microvessels; Diabetes; Endothelial barrier function; Endothelial GSH; Free radicals; Methylglyoxal; Occludin glycation

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; GLUTATHIONE; HYDROGEN PEROXIDE; LACTIC ACID; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL; OCCLUDIN; PROTEIN ZO1; REACTIVE OXYGEN METABOLITE; TEMPOL; TIRON;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; BRAIN DYSFUNCTION; BRAIN HOMOGENATE; BRAIN METABOLISM; CATALYSIS; CELL JUNCTION; CONTROLLED STUDY; DIABETES MELLITUS; ELECTRIC RESISTANCE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INHIBITION KINETICS; MEMBRANE PERMEABILITY; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN SYNTHESIS; RAT; TRANSENDOTHELIAL ELECTRICAL RESISTANCE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM; GLUTATHIONE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; MALE; MICROVESSELS; OCCLUDIN; OXIDATIVE STRESS; POLYMERIZATION; PROTEIN CARBONYLATION; PYRUVALDEHYDE; RATS; RATS, WISTAR; ZONULA OCCLUDENS-1 PROTEIN;

RATTUS;

EID: 84870296895     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.10.552     Document Type: Article

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