Familial narcolepsy in the Lipizzaner horse: A report of three fillies born to the same sire

Veterinary Quarterly

Volumn 32, Issue 2, 2012, Pages 99-102

  Ludvikova, Eva ^a   Nishino, Seiji ^b   Sakai, Noriaki ^b   Jahn, Petr ^a  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Cataplexy; Cerebrospinal fluid; Horse; Hypocretin; Lipizzaner; Narcolepsy

Indexed keywords

OREXIN A; PHYSOSTIGMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BIOCHEMICAL COMPOSITION; CEREBROSPINAL FLUID ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FAMILIAL DISEASE; FAMILY HISTORY; HORSE DISEASE; MALE; NARCOLEPSY; NEUROLOGIC EXAMINATION; NONHUMAN; RADIOIMMUNOASSAY; SLEEP INDUCTION; SOMNOLENCE; STALLION;

ANIMALS; FEMALE; HORSE DISEASES; HORSES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NARCOLEPSY; NEUROPEPTIDES; PHYSOSTIGMINE;

EQUIDAE;

EID: 84870289008     PISSN: 01652176     EISSN: 18755941     Source Type: Journal    
DOI: 10.1080/01652176.2012.714089     Document Type: Article

References (17)

1. Aleman M, Williams C, Holliday T. 2008. Sleep and sleep disorders in horses. AAEP Proc. 54:180-185.
2. Bathen-Nothen A, Heider C, Fernandez AJ, Beineke A, Sewel AC, Otto M, Tipold A. 2009. Hypocretin measure-ment in an Icelandic foal with narcolepsy. J. Vet. Internal Med. 23:1299-1302.
3. Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M. 2004. Expression of polyglutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J. Neurosci. 24:4469-4477.
4. Hines, M. 2005. Narcolepsy: More common than you think? Proceeding of the North American Veterinary Conference; Orlando. Available from: http://www.ivis.org/proceedings/navc/2005/LA/085.pdf?LA=1
5. ICSD-2. 2005. International classification of sleep disorders. Diagnostic and coding manual. 2nd ed. Westchester (IL): American Academy of Sleep Medicine.
6. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E. 1999. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98:365-376.
7. Lunn DP, Cuddon PA, Shaftoe S, Archer RM. 1993. Familial occurrence of narcolepsy in Miniature horses. Equine Vet. J. 25:483-487.
8. Mignot E. 1998. Genetic and familial aspects of narcolepsy. Neurology. 50:S16-S22.
9. Mignot E. 2004. Sleep, sleep disorders and hypocretin (orexin). Sleep Med. 5 (Suppl. 1):S2-S8.
10. Mignot E, Lammers J, Ripley B, Okun M, Nevsimalova S, Overeem S, Vankova J, Black J, Harsh J, Basseti C, et al. 2002. The role of cerebrospinal fluid hypocretin measure-ment in the diagnosis of narcolepsy and other hypersom-nias. Arch. Neurol. 59:1553-1562.
11. Nevsimalova S. 2009. Narcolepsy in childhood. Sleep Med. Rev. 13:169-180.
12. Nishino S, Mignot E. 1997. Pharmacology aspects of human and canine narcolepsy. Prog. Neurobiol. 52:27-78.
13. Nishino S, Mignot E. 2011. Narcolepsy and cataplexy. Handb. Clin. Neurol. 99:783-814.
14. Nishino S, Riehl J, Hong J, Kwan M, Reid M, Mignot E. 2000. Is narcolepsy REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans. Neurosci. Res. 38: 437-446.
15. Ripley B, Fujiki N, Okura M, Mignot E, Nishino S. 2001. Hypocretin levels in sporadic and familial cases of canine narcolepsy. Neurobiol. Dis. 8:525-534.
16. Sheather AL. 1924. Fainting in foals. J. Comp. Pathol. 37:106-113.
17. Sweeney CR, Hendricks JC, Beech J, Morrison AR. 1983. Narcolepsy in a horse. J. Am. Vet. Med. Assoc. 183:126-128.