메뉴 건너뛰기




Volumn , Issue , 2012, Pages 309-325

Physiological and Laboratory Markers of Drug Effect

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84870283851     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-385471-1.00018-0     Document Type: Chapter
Times cited : (2)

References (86)
  • 1
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group (2001) Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin Pharmacol Ther 69 89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 2
    • 0038004636 scopus 로고    scopus 로고
    • Clinical biomarkers in drug discovery and development
    • R. Frank and R. Hargreaves (2003) Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov 2 566-580.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 566-580
    • Frank, R.1    Hargreaves, R.2
  • 3
    • 0036399255 scopus 로고    scopus 로고
    • Overview of biomarkers and surrogate endpoints in drug development
    • J.A. Wagner (2002) Overview of biomarkers and surrogate endpoints in drug development. Dis Markers 18 41-46.
    • (2002) Dis Markers , vol.18 , pp. 41-46
    • Wagner, J.A.1
  • 4
    • 41149108215 scopus 로고    scopus 로고
    • Strategic approach to fit-for-purpose biomarkers in drug development
    • J.A. Wagner (2008) Strategic approach to fit-for-purpose biomarkers in drug development. Ann Rev Pharmacol Toxicol 48 631-651.
    • (2008) Ann Rev Pharmacol Toxicol , vol.48 , pp. 631-651
    • Wagner, J.A.1
  • 5
    • 78449294101 scopus 로고    scopus 로고
    • Assessing the clinical utility of diagnostics used in drug therapy
    • J. Woodcock (2010) Assessing the clinical utility of diagnostics used in drug therapy. Clin Pharmacol Ther 88 765-773.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 765-773
    • Woodcock, J.1
  • 6
    • 77957889860 scopus 로고    scopus 로고
    • C.M. Michael, J.R. Ball (Eds), Washington, DC: The National Academies Press
    • Institute of Medicine Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease (2010) C.M. Michael, J.R. Ball (Eds) Evaluation of biomarkers and surrogate endpoints in chronic disease Washington, DC: The National Academies Press
    • (2010) Evaluation of biomarkers and surrogate endpoints in chronic disease
  • 8
    • 0005905707 scopus 로고    scopus 로고
    • Rockville, MD: FDA, (Internet at, ), Guidance for Industry
    • CDER CVM (2001) Bioanalytical method validation. Rockville, MD: FDA (Internet at www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070107.pdf ) Guidance for Industry
    • (2001) Bioanalytical method validation
  • 9
  • 11
    • 0038575226 scopus 로고    scopus 로고
    • Standard reference material for HER2 testing: Report of a National Institute of Standards and Technology-sponsored Consensus Workshop
    • M. Elizabeth, H. Hammond, P. Barker, S. Taube and S. Gutman (2003) Standard reference material for HER2 testing: Report of a National Institute of Standards and Technology-sponsored Consensus Workshop. Appl Immunohistochem Mol Morphol 11 103-106.
    • (2003) Appl Immunohistochem Mol Morphol , vol.11 , pp. 103-106
    • Elizabeth, M.1    Hammond, H.2    Barker, P.3    Taube, S.4    Gutman, S.5
  • 12
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • A.C. Wolff, M. Elizabeth, H. Hammond, J.N. Schwartz, K.L. Hagerty, D.C. Aldred, et al. (2007) American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 25 118-145.
    • (2007) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Elizabeth, M.2    Hammond, H.3    Schwartz, J.N.4    Hagerty, K.L.5    Aldred, D.C.6
  • 13
    • 61349123591 scopus 로고    scopus 로고
    • Diffusion-weighted magnetic resonance imaging as a cancer biomarker: Consensus and recommendations
    • A.R. Padhani, G. Liu, D. Mu-Koh, T.L. Chenevert, H.C. Thoeny, T. Takahara, et al. (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: Consensus and recommendations. Neoplasia 11 1102-1125.
    • (2009) Neoplasia , vol.11 , pp. 1102-1125
    • Padhani, A.R.1    Liu, G.2    Mu-Koh, D.3    Chenevert, T.L.4    Thoeny, H.C.5    Takahara, T.6
  • 15
    • 39749134121 scopus 로고    scopus 로고
    • Mattes. Strategic paths for biomarker qualification
    • F.M. Goodsaid and F.W. Frueh (2008) Mattes. Strategic paths for biomarker qualification. Toxicology 245 219-223.
    • (2008) Toxicology , vol.245 , pp. 219-223
    • Goodsaid, F.M.1    Frueh, F.W.2
  • 17
    • 77956470019 scopus 로고    scopus 로고
    • Translational medicine and the value of biomarker qualification
    • ps44
    • F.M. Goodsaid and D.L. Mendrick (2010) Translational medicine and the value of biomarker qualification. Sci Transl Med 2 47. ps44
    • (2010) Sci Transl Med , vol.2 , pp. 47
    • Goodsaid, F.M.1    Mendrick, D.L.2
  • 19
    • 0033603814 scopus 로고    scopus 로고
    • Are surrogate markers adequate to assess cardiovascular disease drugs?
    • R. Temple (1999) Are surrogate markers adequate to assess cardiovascular disease drugs? JAMA 282 790-795.
    • (1999) JAMA , vol.282 , pp. 790-795
    • Temple, R.1
  • 20
    • 0035037328 scopus 로고    scopus 로고
    • Use of biomarkers and surrogate endpoints in drug development and regulatory decision making
    • L.J. Lesko and A.J. Atkinson Jr. (2001) Use of biomarkers and surrogate endpoints in drug development and regulatory decision making. Ann Rev Pharmacol 41 347-366.
    • (2001) Ann Rev Pharmacol , vol.41 , pp. 347-366
    • Lesko, L.J.1    Atkinson, A.J.2
  • 21
    • 0003077113 scopus 로고
    • A regulatory authority’s opinion about surrogate endpoints
    • W.S. Nimmo, G.T. Tucker (Eds), New York, NY: J Wiley
    • R.J. Temple (1995) A regulatory authority’s opinion about surrogate endpoints. W.S. Nimmo, G.T. Tucker (Eds) Clinical measurement in drug evaluation New York, NY: J Wiley
    • (1995) Clinical measurement in drug evaluation
    • Temple, R.J.1
  • 22
    • 0030268577 scopus 로고    scopus 로고
    • Surrogate endpoints in clinical trials: Are we being misled?
    • T.R. Fleming and D.L. DeMets (1996) Surrogate endpoints in clinical trials: Are we being misled? Ann Intern Med 125 605-613.
    • (1996) Ann Intern Med , vol.125 , pp. 605-613
    • Fleming, T.R.1    DeMets, D.L.2
  • 23
    • 0033603814 scopus 로고    scopus 로고
    • Are surrogate markers adequate to assess cardiovascular disease drugs?
    • R. Temple (1999) Are surrogate markers adequate to assess cardiovascular disease drugs? JAMA 282 790-795.
    • (1999) JAMA , vol.282 , pp. 790-795
    • Temple, R.1
  • 24
    • 0026011647 scopus 로고
    • Mortality and morbidity of patients receiving encainide, flecainide or placebo: The Cardiac Arrhythmia Suppression Trial
    • D.S. Echt, P.R. Liebson, B. Mitchell, R.W. Peters, D. Obias-Manno, A.H. Barker, et al., CAST Investigators (1991) Mortality and morbidity of patients receiving encainide, flecainide or placebo: The Cardiac Arrhythmia Suppression Trial. N Engl J Med 324 781-788.
    • (1991) N Engl J Med , vol.324 , pp. 781-788
    • Echt, D.S.1    Liebson, P.R.2    Mitchell, B.3    Peters, R.W.4    Obias-Manno, D.5    Barker, A.H.6
  • 25
    • 0024520844 scopus 로고
    • Surrogate endpoints in clinical trials: Definition and operational criteria
    • R.L. Prentice (1989) Surrogate endpoints in clinical trials: Definition and operational criteria. Stat Med 8 431-440.
    • (1989) Stat Med , vol.8 , pp. 431-440
    • Prentice, R.L.1
  • 27
    • 0026573094 scopus 로고
    • Statistical validation of intermediate endpoints for chronic diseases
    • L.S. Freedman and B.I. Graubard (1992) Statistical validation of intermediate endpoints for chronic diseases. Stat Med 11 167-178.
    • (1992) Stat Med , vol.11 , pp. 167-178
    • Freedman, L.S.1    Graubard, B.I.2
  • 28
    • 0030771191 scopus 로고    scopus 로고
    • Estimating the proportion of treatment effect explained by a surrogate marker
    • D.Y. Lin, T.R. Fleming and V. De Gruttola (1997) Estimating the proportion of treatment effect explained by a surrogate marker. Stat Med 16 1515-1527.
    • (1997) Stat Med , vol.16 , pp. 1515-1527
    • Lin, D.Y.1    Fleming, T.R.2    De Gruttola, V.3
  • 29
    • 0034802767 scopus 로고    scopus 로고
    • Considerations in the evaluation of surrogate endpoints in clinical trials: Summary of a National Institutes of Health workshop
    • V.G. De Gruttola, P. Clax, D.L. DeMets, G.J. Downing, S.S. Ellenberg, L. Friedman, et al. (2001) Considerations in the evaluation of surrogate endpoints in clinical trials: Summary of a National Institutes of Health workshop. Control Clin Trials 22 485-502.
    • (2001) Control Clin Trials , vol.22 , pp. 485-502
    • De Gruttola, V.G.1    Clax, P.2    DeMets, D.L.3    Downing, G.J.4    Ellenberg, S.S.5    Friedman, L.6
  • 30
    • 0003577283 scopus 로고    scopus 로고
    • April 1,, Washington, DC: US Government Printing Office, Title 21, Vol. 5, Parts 300–499
    • Code of Federal Regulations. Washington, DC: US Government Printing Office Title 21, Vol. 5, Parts 300–499
    • (1997) Code of Federal Regulations
  • 31
    • 0034632793 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 RNA level and CD4 count as prognostic markers and surrogate endpoints: A meta-analysis
    • HIV Surrogate Marker Collaborative Group (2000) Human immunodeficiency virus type 1 RNA level and CD4 count as prognostic markers and surrogate endpoints: A meta-analysis. AISA Res Hum Retroviruses 16 1123-1132.
    • (2000) AISA Res Hum Retroviruses , vol.16 , pp. 1123-1132
  • 33
    • 67650604373 scopus 로고    scopus 로고
    • The value, qualification and regulatory use of surrogate endpoints in drug development
    • C.D. Lathia, D. Amakye, C. Girman, S. Madani, J. Mayne, P. MacCarthy, et al. (2009) The value, qualification and regulatory use of surrogate endpoints in drug development. Clin Pharmacol Ther 86 32-43.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 32-43
    • Lathia, C.D.1    Amakye, D.2    Girman, C.3    Madani, S.4    Mayne, J.5    MacCarthy, P.6
  • 34
    • 84866742085 scopus 로고    scopus 로고
    • Draft Guidance for Industry, Rockville, MD: FDA, ), (Internet at
    • CDRH CDER CBER (2011) In vitro companion diagnostic devices. Draft Guidance for Industry, Rockville, MD: FDA www.fda.gov/downloads/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/UCM262327.pdf ) (Internet at
    • (2011) In vitro companion diagnostic devices
  • 35
    • 70350440515 scopus 로고    scopus 로고
    • The J-curve between blood pressure and coronary artery disease or essential hypertension
    • F.H. Messerli and G.S. Panjrath (2009) The J-curve between blood pressure and coronary artery disease or essential hypertension. J Am Coll Cardiol 54 1827-1834.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1827-1834
    • Messerli, F.H.1    Panjrath, G.S.2
  • 36
    • 65449180405 scopus 로고    scopus 로고
    • Hypertension: Reflections on risks and prognostication
    • W.B. Kannel (2009) Hypertension: Reflections on risks and prognostication. Med Clin North Am 93 541-556.
    • (2009) Med Clin North Am , vol.93 , pp. 541-556
    • Kannel, W.B.1
  • 37
    • 0016700886 scopus 로고
    • How does blood-pressure cause stroke?
    • R.W.R. Russell (1975) How does blood-pressure cause stroke? Lancet ii 1283-1285.
    • (1975) Lancet , vol.ii , pp. 1283-1285
    • Russell, R.W.R.1
  • 38
    • 84881265016 scopus 로고    scopus 로고
    • Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    • M.R. Law, J.K. Morris and N.J. Wald (2009) Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 32 729-741.
    • (2009) BMJ , vol.32 , pp. 729-741
    • Law, M.R.1    Morris, J.K.2    Wald, N.J.3
  • 40
    • 0034700445 scopus 로고    scopus 로고
    • The FDA, regulation, and the risk of stroke
    • G.A. Fleming (2000) The FDA, regulation, and the risk of stroke. N Engl J Med 343 1886.
    • (2000) N Engl J Med , vol.343 , pp. 1886
    • Fleming, G.A.1
  • 41
    • 77956284607 scopus 로고    scopus 로고
    • Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects
    • W. Philip, T. James, I.D. Caterson, W. Coutinho, N. Finer, L.F. Van Gaal, et al., for the SCOUT Investigators (2010) Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 363 905-917.
    • (2010) N Engl J Med , vol.363 , pp. 905-917
    • Philip, W.1    James, T.2    Caterson, I.D.3    Coutinho, W.4    Finer, N.5    Van Gaal, L.F.6
  • 42
    • 64149124608 scopus 로고    scopus 로고
    • Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis. J Chromatogr B Analyt Technol
    • J.W. Lee and M. Hall (2009) Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis. J Chromatogr B Analyt Technol. Biomed Life Sci 877 1259-1271.
    • (2009) Biomed Life Sci , vol.877 , pp. 1259-1271
    • Lee, J.W.1    Hall, M.2
  • 43
    • 78149330220 scopus 로고    scopus 로고
    • Biomarkers in Alzheimer’s disease drug development
    • K. Blennow (2010) Biomarkers in Alzheimer’s disease drug development. Nat Med 16 1218-1222.
    • (2010) Nat Med , vol.16 , pp. 1218-1222
    • Blennow, K.1
  • 44
    • 38149081191 scopus 로고    scopus 로고
    • Imaging of amyloid β in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism
    • C.C. Rowe, U. Ackerman, W. Browne, R. Mulligan, K.L. Pike, G. O’Keefe, et al. (2008) Imaging of amyloid β in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism. Lancet Neurol 7 129-135.
    • (2008) Lancet Neurol , vol.7 , pp. 129-135
    • Rowe, C.C.1    Ackerman, U.2    Browne, W.3    Mulligan, R.4    Pike, K.L.5    O’Keefe, G.6
  • 45
    • 0026080644 scopus 로고
    • Measurement of human cerebral monamine oxidase type B (MAO-B) activity with positron emission tomography (PET): A dose ranging study with the reversible inhibitor Ro 19-6327
    • C.J. Bench, G.W. Price, A.A. Lammertsma, J.C. Cremer, S.K. Luthra, D. Turton, et al. (1991) Measurement of human cerebral monamine oxidase type B (MAO-B) activity with positron emission tomography (PET): A dose ranging study with the reversible inhibitor Ro 19-6327. Eur J Clin Pharmacol 40 169-173.
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 169-173
    • Bench, C.J.1    Price, G.W.2    Lammertsma, A.A.3    Cremer, J.C.4    Luthra, S.K.5    Turton, D.6
  • 46
    • 33846459685 scopus 로고    scopus 로고
    • Current issues relating to drug safety especially with regard to the use of biomarkers: A meeting report and progress update
    • P. Rolan, M. Danhof, D. Stanski and C. Peck (2007) Current issues relating to drug safety especially with regard to the use of biomarkers: A meeting report and progress update. Eur J Pharm Sci 30 107-113.
    • (2007) Eur J Pharm Sci , vol.30 , pp. 107-113
    • Rolan, P.1    Danhof, M.2    Stanski, D.3    Peck, C.4
  • 47
    • 0242312707 scopus 로고    scopus 로고
    • Drug methylation in cancer therapy: Lessons from the TPMT polymorphism
    • E. Krynetski and W.E. Evans (2003) Drug methylation in cancer therapy: Lessons from the TPMT polymorphism. Oncogene 22 7403-7413.
    • (2003) Oncogene , vol.22 , pp. 7403-7413
    • Krynetski, E.1    Evans, W.E.2
  • 50
    • 77953811288 scopus 로고    scopus 로고
    • Covariate analysis of QTc and T-wave morphology: New possibilities in the evaluation of drugs that affect cardiac repolarization
    • C. Graff, J.J. Struijk, J. Matz, J.K. Kanters, M.P. Andersen, J. Nielsen, et al. (2010) Covariate analysis of QTc and T-wave morphology: New possibilities in the evaluation of drugs that affect cardiac repolarization. Clin Pharmacol Ther 88 88-94.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 88-94
    • Graff, C.1    Struijk, J.J.2    Matz, J.3    Kanters, J.K.4    Andersen, M.P.5    Nielsen, J.6
  • 51
    • 77953811461 scopus 로고    scopus 로고
    • The systems biology approach to drug development: Application to toxicity assessment of cardiac drugs
    • B. Rodriguez, K. Burrage, D. Gavaghan, V. Grau, P. Kohl and D. Noble (2010) The systems biology approach to drug development: Application to toxicity assessment of cardiac drugs. Clin Pharmacol Ther 88 130-134.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 130-134
    • Rodriguez, B.1    Burrage, K.2    Gavaghan, D.3    Grau, V.4    Kohl, P.5    Noble, D.6
  • 52
    • 0026527178 scopus 로고
    • Should there be a moratorium on the use of cholesterol lowering drugs?
    • G. Davey Smith and J. Pekkanen (1992) Should there be a moratorium on the use of cholesterol lowering drugs? BMJ 304 431-434.
    • (1992) BMJ , vol.304 , pp. 431-434
    • Davey Smith, G.1    Pekkanen, J.2
  • 53
    • 0025216049 scopus 로고
    • The cholesterol facts: A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease: A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute
    • J.C. LaRosa, D. Hunninghake, M.H. Criqui, G.S. Getz, A.M. Gotto Jr., S.M. Grundy, et al. (1990) The cholesterol facts: A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease: A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute. Circulation 81 1721-1733.
    • (1990) Circulation , vol.81 , pp. 1721-1733
    • LaRosa, J.C.1    Hunninghake, D.2    Criqui, M.H.3    Getz, G.S.4    Gotto, A.M.5    Grundy, S.M.6
  • 54
    • 0025276302 scopus 로고
    • Can atherosclerotic plaques regress? Anatomic and biochemical evidence from nonhuman animal models
    • R.W. Wissler and D. Vesselinovitch (1990) Can atherosclerotic plaques regress? Anatomic and biochemical evidence from nonhuman animal models. Am J Cardiol 65 33F-40F.
    • (1990) Am J Cardiol , vol.65 , pp. 33F-40F
    • Wissler, R.W.1    Vesselinovitch, D.2
  • 55
    • 0023008776 scopus 로고
    • Gevers Leuven JA, Schouten JA, Stalenhoef AFH. Effects of synvinolin (MK-733) on plasma lipids in familial hypercholesterolaemia
    • M.J.T.M. Mol and D.W. Erkelens (1986) Gevers Leuven JA, Schouten JA, Stalenhoef AFH. Effects of synvinolin (MK-733) on plasma lipids in familial hypercholesterolaemia. Lancet ii 936-939.
    • (1986) Lancet , vol.ii , pp. 936-939
    • Mol, M.J.T.M.1    Erkelens, D.W.2
  • 56
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 344 1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 57
    • 0032554686 scopus 로고    scopus 로고
    • Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study
    • T.R. Pedersen, A.G. Olsson, O. Færgeman, J. Kjekshus, H. Wedel, K. Berg, et al., for the Scandinavian Simvastatin Survival Study Group (1998) Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study. Circulation 97 1453-1460.
    • (1998) Circulation , vol.97 , pp. 1453-1460
    • Pedersen, T.R.1    Olsson, A.G.2    Færgeman, O.3    Kjekshus, J.4    Wedel, H.5    Berg, K.6
  • 58
    • 4544275379 scopus 로고    scopus 로고
    • Coordinating Committee of the National Cholesterol Education Program. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    • S.M. Grundy, J.I. Cleeman, C.N. Merz, H.B. Brewer Jr., L.T. Clark, D.B. Hunninghake, et al. (2004) Coordinating Committee of the National Cholesterol Education Program. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 44 720-732.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 720-732
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3    Brewer, H.B.4    Clark, L.T.5    Hunninghake, D.B.6
  • 59
    • 0000306390 scopus 로고    scopus 로고
    • Statins do more than just lower cholesterol
    • C.J. Vaughan, M.B. Murphy and B.M. Buckley (1996) Statins do more than just lower cholesterol. Lancet 348 1079-1082.
    • (1996) Lancet , vol.348 , pp. 1079-1082
    • Vaughan, C.J.1    Murphy, M.B.2    Buckley, B.M.3
  • 60
    • 0032554676 scopus 로고    scopus 로고
    • Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS)
    • West of Scotland Coronary Prevention Study Group (1998) Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 97 1440-1445.
    • (1998) Circulation , vol.97 , pp. 1440-1445
  • 61
    • 70349742564 scopus 로고    scopus 로고
    • C-reactive protein as a risk factor for coronary heart disease: A systematic review and meta-analysis for the US Preventive Services Task Force
    • D.L. Buckley, R. Fu, M. Freeman, K. Rogers and M. Helfand (2009) C-reactive protein as a risk factor for coronary heart disease: A systematic review and meta-analysis for the US Preventive Services Task Force. Ann Intern Med 151 483-496.
    • (2009) Ann Intern Med , vol.151 , pp. 483-496
    • Buckley, D.L.1    Fu, R.2    Freeman, M.3    Rogers, K.4    Helfand, M.5
  • 63
    • 62649086172 scopus 로고    scopus 로고
    • The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis
    • A. Blum and R. Shamburek (2009) The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Atherosclerosis 203 325-330.
    • (2009) Atherosclerosis , vol.203 , pp. 325-330
    • Blum, A.1    Shamburek, R.2
  • 64
    • 0029884597 scopus 로고    scopus 로고
    • Probucol-associated tachyarrhythmic events and QT prolongation: Importance of gender
    • J. Reinoehl, D. Frankovich, C. Machado, R. Kawasaki, J.J. Baga, L.A. Pires, et al. (1996) Probucol-associated tachyarrhythmic events and QT prolongation: Importance of gender. Am Heart J 131 1184-1191.
    • (1996) Am Heart J , vol.131 , pp. 1184-1191
    • Reinoehl, J.1    Frankovich, D.2    Machado, C.3    Kawasaki, R.4    Baga, J.J.5    Pires, L.A.6
  • 65
    • 78650778472 scopus 로고    scopus 로고
    • Adjunctive lipid lowering therapy in the era of surrogate endpoints
    • M.G. Silverman, M.J. Blaha and R.S. Blumenthal (2011) Adjunctive lipid lowering therapy in the era of surrogate endpoints. Cardiol Rev 19 17-22.
    • (2011) Cardiol Rev , vol.19 , pp. 17-22
    • Silverman, M.G.1    Blaha, M.J.2    Blumenthal, R.S.3
  • 67
    • 33846609195 scopus 로고    scopus 로고
    • Prediction of cardiovascular events with carotid intima–media thickness – a systemic review and meta-analysis
    • M.W. Lorenz, H.S. Markus, M.L. Bots, M. Rosvall and M. Sitzer (2007) Prediction of cardiovascular events with carotid intima–media thickness – a systemic review and meta-analysis. Circulation 115 459-467.
    • (2007) Circulation , vol.115 , pp. 459-467
    • Lorenz, M.W.1    Markus, H.S.2    Bots, M.L.3    Rosvall, M.4    Sitzer, M.5
  • 68
    • 77951674231 scopus 로고    scopus 로고
    • PROG-IMT Study Group. Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project
    • M.W. Lorenz, H. Bickel, M.L. Bots, M.M.B. Breteler, A.L. Catapano, M. Desvarieux, et al. (2010) PROG-IMT Study Group. Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project. Am Heart J 159 730-736.
    • (2010) Am Heart J , vol.159 , pp. 730-736
    • Lorenz, M.W.1    Bickel, H.2    Bots, M.L.3    Breteler, M.M.B.4    Catapano, A.L.5    Desvarieux, M.6
  • 69
    • 0030884335 scopus 로고    scopus 로고
    • The contribution of clinical pharmacology surrogates and models to drug development – a critical appraisal
    • P. Rolan (1997) The contribution of clinical pharmacology surrogates and models to drug development – a critical appraisal. Br J Clin Pharmacol 44 219-225.
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 219-225
    • Rolan, P.1
  • 70
    • 79956321442 scopus 로고    scopus 로고
    • Pharmacological mechanism-based drug safety assessment and prediction
    • D.R. Abernethy, J. Woodcock and L.J. Lesko (2011) Pharmacological mechanism-based drug safety assessment and prediction. Clin Pharm Ther 89 793-797.
    • (2011) Clin Pharm Ther , vol.89 , pp. 793-797
    • Abernethy, D.R.1    Woodcock, J.2    Lesko, L.J.3
  • 71
    • 4544335467 scopus 로고    scopus 로고
    • Translation of pharmacogenomics and pharmacogenetics: A regulatory perspective
    • L.J. Lesko and J. Woodcock (2004) Translation of pharmacogenomics and pharmacogenetics: A regulatory perspective. Nat Rev Drug Discov 3 763-769.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 763-769
    • Lesko, L.J.1    Woodcock, J.2
  • 72
    • 67650635229 scopus 로고    scopus 로고
    • UCSF Center for Translational and Policy Research on Personalized Medicine
    • Walsh JM, Ladabaum U, Marshall D. Addressing the challenges of the clinical application of pharmacogenetic testing
    • O.N. Ikediobi, J. Shin, R.L. Nussbaum and K.A. Phillips (2009) UCSF Center for Translational and Policy Research on Personalized Medicine. Clin Pharmacol Ther 86(1), 28-31. Walsh JM, Ladabaum U, Marshall D. Addressing the challenges of the clinical application of pharmacogenetic testing
    • (2009) Clin Pharmacol Ther , vol.86 , Issue.1 , pp. 28-31
    • Ikediobi, O.N.1    Shin, J.2    Nussbaum, R.L.3    Phillips, K.A.4
  • 73
    • 77955654135 scopus 로고    scopus 로고
    • Expectations, validity, and reality in gene expression profiling
    • K. Kim, S.O. Zakharkin and D.B. Allison (2010) Expectations, validity, and reality in gene expression profiling. J Clin Epidemiol 63 950-959.
    • (2010) J Clin Epidemiol , vol.63 , pp. 950-959
    • Kim, K.1    Zakharkin, S.O.2    Allison, D.B.3
  • 74
    • 84984934048 scopus 로고    scopus 로고
    • DNA microarrays in drug discovery and development
    • C. Debouck and P.N. Goodfellow (1999) DNA microarrays in drug discovery and development. Nat Genet 21 48-50.
    • (1999) Nat Genet , vol.21 , pp. 48-50
    • Debouck, C.1    Goodfellow, P.N.2
  • 75
    • 0033394254 scopus 로고    scopus 로고
    • Functional genomics and DNA array techniques in atherosclerosis research
    • M.O. Hiltunen, M. Niemi and S. Ylä-Herttuala (1999) Functional genomics and DNA array techniques in atherosclerosis research. Curr Opin Lipidol 10 515-519.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 515-519
    • Hiltunen, M.O.1    Niemi, M.2    Ylä-Herttuala, S.3
  • 76
    • 14544268597 scopus 로고    scopus 로고
    • Prediction of docetaxel response in human breast cancer by gene expression profiling
    • K. Iwao-Koizumi, R. Matoba, N. Ueno, S.J. Kim, A. Ando, Y. Miyoshi, et al. (2005) Prediction of docetaxel response in human breast cancer by gene expression profiling. J Clin Oncol 23 422-431.
    • (2005) J Clin Oncol , vol.23 , pp. 422-431
    • Iwao-Koizumi, K.1    Matoba, R.2    Ueno, N.3    Kim, S.J.4    Ando, A.5    Miyoshi, Y.6
  • 77
    • 77949422465 scopus 로고    scopus 로고
    • The application of mass-spectrometry-based protein biomarker discovery to theragnostics
    • J.M. Street and J.W. Dear (2009) The application of mass-spectrometry-based protein biomarker discovery to theragnostics. Br J Clin Pharmacol 69 367-378.
    • (2009) Br J Clin Pharmacol , vol.69 , pp. 367-378
    • Street, J.M.1    Dear, J.W.2
  • 78
  • 79
    • 78649906756 scopus 로고    scopus 로고
    • Status of tumor markers in epithelial ovarian cancer: Has there been any progress? A review
    • N. Husseinzadeh (2011) Status of tumor markers in epithelial ovarian cancer: Has there been any progress? A review. Gynecol Oncol 120 152-157.
    • (2011) Gynecol Oncol , vol.120 , pp. 152-157
    • Husseinzadeh, N.1
  • 81
    • 13844322072 scopus 로고    scopus 로고
    • Lessons from controversy: Ovarian cancer screening and proteomics
    • D.F. Ransohoff (2005) Lessons from controversy: Ovarian cancer screening and proteomics. J Natl Cancer Inst 97 315-319.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 315-319
    • Ransohoff, D.F.1
  • 82
    • 70349686577 scopus 로고    scopus 로고
    • Clinical application of proteomics in ovarian cancer prevention and treatment
    • F. Meani, S. Pecorelli, L. Liotta and E.F. Petricoin (2009) Clinical application of proteomics in ovarian cancer prevention and treatment. Mol Diag Ther 13 297-311.
    • (2009) Mol Diag Ther , vol.13 , pp. 297-311
    • Meani, F.1    Pecorelli, S.2    Liotta, L.3    Petricoin, E.F.4
  • 83
    • 64649105107 scopus 로고    scopus 로고
    • Development and validation of a protein based signature for the detection of ovarian cancer
    • K. Kim, I. Vishintin, A.B. Alvero and G. Mor (2009) Development and validation of a protein based signature for the detection of ovarian cancer. Clin Lab Med 29 47-55.
    • (2009) Clin Lab Med , vol.29 , pp. 47-55
    • Kim, K.1    Vishintin, I.2    Alvero, A.B.3    Mor, G.4
  • 84
    • 0032402905 scopus 로고    scopus 로고
    • The integration of microarray information in the drug development process
    • S. Braxton and T. Bedilion (1998) The integration of microarray information in the drug development process. Curr Opin Biotechnol 9 643-649.
    • (1998) Curr Opin Biotechnol , vol.9 , pp. 643-649
    • Braxton, S.1    Bedilion, T.2
  • 85
  • 86
    • 79952112647 scopus 로고    scopus 로고
    • Bioinformatics for LC-MS/MS-based proteomics
    • R.J. Jacob (2010) Bioinformatics for LC-MS/MS-based proteomics. Methods Mol Biol 658 61-91.
    • (2010) Methods Mol Biol , vol.658 , pp. 61-91
    • Jacob, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.