메뉴 건너뛰기




Volumn 19, Issue 1, 2011, Pages 17-22

Adjunctive lipid lowering therapy in the era of surrogate endpoints

Author keywords

atherosclerosis; coronary artery disease; ezetimibe; Niacin; surrogate markers

Indexed keywords

ANTILIPEMIC AGENT; EZETIMIBE; EZETIMIBE PLUS SIMVASTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAROPIPRANT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; PLACEBO; SIMVASTATIN; TORCETRAPIB;

EID: 78650778472     PISSN: 10615377     EISSN: None     Source Type: Journal    
DOI: 10.1097/CRD.0b013e3181fc212a     Document Type: Review
Times cited : (7)

References (37)
  • 1
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterollowering treatment: Prospective meta-analysis of data from 90,056 participants in 14. randomised trials of statins
    • Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterollowering treatment: prospective meta-analysis of data from 90,056 participants in 14. randomised trials of statins. Lancet. 2005;366:1267-1278.
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 2
    • 0033596281 scopus 로고    scopus 로고
    • Effect of statins on risk of coronary disease: A meta-analysis of randomized controlled trials
    • LaRosa J, He J, Vupputuri S. Effect of statins on risk of coronary disease: A meta-analysis of randomized controlled trials. JAMA. 1999;282:2340-2346.
    • (1999) JAMA , vol.282 , pp. 2340-2346
    • LaRosa, J.1    He, J.2    Vupputuri, S.3
  • 4
    • 27744522317 scopus 로고    scopus 로고
    • The forgotten majority: Unfinished business in cardiovascular risk reduction
    • Libby P. The forgotten majority: Unfinished business in cardiovascular risk reduction. J Am Coll Cardiol. 2005;46:1225-1228.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1225-1228
    • Libby, P.1
  • 5
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • Taylor AJ, Villines TC, Stanek EJ, et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med. 2009;361:2113-2122.
    • (2009) N Engl J Med , vol.361 , pp. 2113-2122
    • Taylor, A.J.1    Villines, T.C.2    Stanek, E.J.3
  • 6
    • 70350516769 scopus 로고    scopus 로고
    • Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: A randomized, placebo- controlled, magnetic resonance imaging study
    • Lee JM, Robson MD, Yu L-M, et al. Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study. J Am Coll Cardiol. 2009;54:1787-1794.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1787-1794
    • Lee, J.M.1    Robson, M.D.2    Yu, L.-M.3
  • 7
    • 78650788625 scopus 로고    scopus 로고
    • Comparative effect of statins vs. niacin on MRI measured regression of carotid atherosclerosis in a randomized clinical trial: The NIA plaque study
    • Sibley CT, Gottlieb I, Cox C, et al. Comparative effect of statins vs. niacin on MRI measured regression of carotid atherosclerosis in a randomized clinical trial: The NIA plaque study. Abstract 685.
    • Abstract , vol.685
    • Sibley, C.T.1    Gottlieb, I.2    Cox, C.3
  • 8
    • 34547858847 scopus 로고    scopus 로고
    • High-density lipoprotein as a therapeutic target: A systematic review
    • Singh IM, Shishehbor MH, Ansell BJ. High-density lipoprotein as a therapeutic target: A systematic review. JAMA. 2007;298:786-798.
    • (2007) JAMA , vol.298 , pp. 786-798
    • Singh, I.M.1    Shishehbor, M.H.2    Ansell, B.J.3
  • 9
    • 41149175907 scopus 로고    scopus 로고
    • Mechanism of action of niacin
    • Kamanna V, Kashyap M. Mechanism of action of niacin. Am J Cardiol. 2008;101:20-26.
    • (2008) Am J Cardiol , vol.101 , pp. 20-26
    • Kamanna, V.1    Kashyap, M.2
  • 10
    • 0016630250 scopus 로고
    • Clofibrate and niacin in coronary heart disease
    • The Coronary Drug Project Research Group
    • The Coronary Drug Project Research Group. Clofibrate and niacin in coronary heart disease. JAMA. 1975;231:360-381.
    • (1975) JAMA , vol.231 , pp. 360-381
  • 11
    • 11844296800 scopus 로고    scopus 로고
    • Efficacy and safety of high-density lipoprotein cholesterol increasing compounds. A meta-analysis of randomized control trials
    • Birjmohun R, Hutten B, Kastelein J, et al. Efficacy and safety of high-density lipoprotein cholesterol increasing compounds. A meta-analysis of randomized control trials. J Am Coll Cardiol. 2005;45:185-197.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 185-197
    • Birjmohun, R.1    Hutten, B.2    Kastelein, J.3
  • 12
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown B, Zhao X, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001;345:1583-1592.
    • (2001) N Engl J Med , vol.345 , pp. 1583-1592
    • Brown, B.1    Zhao, X.2    Chait, A.3
  • 13
    • 10044281651 scopus 로고    scopus 로고
    • Atertial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor AJ, Sullenberger LE, Lee HJ, et al. Atertial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation. 2004;110:3512-3517.
    • (2004) Circulation , vol.110 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3
  • 14
    • 33751217682 scopus 로고    scopus 로고
    • The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3
    • Taylor AJ, Lee HJ, Sullenberger LE. The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3. Curr Med Res Opin. 2006;22:2243-2250.
    • (2006) Curr Med Res Opin , vol.22 , pp. 2243-2250
    • Taylor, A.J.1    Lee, H.J.2    Sullenberger, L.E.3
  • 15
    • 41149128233 scopus 로고    scopus 로고
    • Surrogate end points and FDA approval. A tale of 2 lipid-altering drugs
    • Psaty B, Lumley T. Surrogate end points and FDA approval. A tale of 2 lipid-altering drugs. JAMA. 2008;299:1474-1476.
    • (2008) JAMA , vol.299 , pp. 1474-1476
    • Psaty, B.1    Lumley, T.2
  • 16
    • 0037395141 scopus 로고    scopus 로고
    • Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia
    • Knopp R, Gitter H, Truitt T, et al. Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. Eur Heart J. 2003;24:729-741.
    • (2003) Eur Heart J , vol.24 , pp. 729-741
    • Knopp, R.1    Gitter, H.2    Truitt, T.3
  • 17
    • 0038755662 scopus 로고    scopus 로고
    • Perspectives in cholesterol-lowering therapy. The role of ezetimibe, a new selective inhibitor of intestinal cholesterol absorption
    • Bruckert E, Giral P, Tellier P. Perspectives in cholesterol-lowering therapy. The role of ezetimibe, a new selective inhibitor of intestinal cholesterol absorption. Circulation. 2003;107:3124-3128.
    • (2003) Circulation , vol.107 , pp. 3124-3128
    • Bruckert, E.1    Giral, P.2    Tellier, P.3
  • 18
    • 41649107358 scopus 로고    scopus 로고
    • Simvastatin with or without ezetimibe in familial hypercholesterolemia
    • Kastelein J, Akdim F, Stroes E, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med. 2008;358:1431-1443.
    • (2008) N Engl J Med , vol.358 , pp. 1431-1443
    • Kastelein, J.1    Akdim, F.2    Stroes, E.3
  • 19
    • 57449105069 scopus 로고    scopus 로고
    • Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes. The SANDS (stop atherosclerosis in native diabetics study) trial
    • Fleg JL, Mete M, Howard BV, et al. Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes. The SANDS (stop atherosclerosis in native diabetics study) trial. J Am Coll Cardiol. 2008;52: 2198-2205.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 2198-2205
    • Fleg, J.L.1    Mete, M.2    Howard, B.V.3
  • 20
    • 67650475384 scopus 로고    scopus 로고
    • The vytorin on carotid intima-media thickness and overall rigidity (VYCTOR) study
    • Meaney A, Ceballos G, Asbun J, et al. The vytorin on carotid intima-media thickness and overall rigidity (VYCTOR) study. J Clin Pharmacol. 2009;49: 838-847.
    • (2009) J Clin Pharmacol , vol.49 , pp. 838-847
    • Meaney, A.1    Ceballos, G.2    Asbun, J.3
  • 21
    • 52649120889 scopus 로고    scopus 로고
    • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • Rossebo AB, Pederson TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359:1343-1356.
    • (2008) N Engl J Med , vol.359 , pp. 1343-1356
    • Rossebo, A.B.1    Pederson, T.R.2    Boman, K.3
  • 22
    • 77953121328 scopus 로고    scopus 로고
    • The ARBITER-6 HALTS trial (arterial biology for the investigation of the treatment effects of reducing cholesterol 6-HDL and LDL treatment strategies in atherosclerosis)
    • doi:10.1016/j.jacc.2010.03.017
    • Villines TC, Stanek EJ, Devine PJ, et al. The ARBITER-6 HALTS trial (arterial biology for the investigation of the treatment effects of reducing cholesterol 6-HDL and LDL treatment strategies in atherosclerosis). J Am Coll Cardiol. 2010;55:2721-2726. doi:10.1016/j.jacc.2010.03.017.
    • (2010) J Am Coll Cardiol. , vol.55 , pp. 2721-2726
    • Villines, T.C.1    Stanek, E.J.2    Devine, P.J.3
  • 23
    • 36348975228 scopus 로고    scopus 로고
    • Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Caulfield M, Eriksson M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109-2122.
    • (2007) N Engl J Med , vol.357 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3
  • 24
    • 34047106220 scopus 로고    scopus 로고
    • Effects of torcetrapib on the progression of coronary atherosclerosis
    • Nissen SE, Tardif JC, Nicholls SJ, et al. Effects of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med. 2007;356:1304-1316.
    • (2007) N Engl J Med , vol.356 , pp. 1304-1316
    • Nissen, S.E.1    Tardif, J.C.2    Nicholls, S.J.3
  • 25
    • 34247241088 scopus 로고    scopus 로고
    • Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
    • Kastelein JJ, van Leuven SI, Burgess L, et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med. 2007;356: 1620-1630.
    • (2007) N Engl J Med , vol.356 , pp. 1620-1630
    • Kastelein, J.J.1    Van Leuven, S.I.2    Burgess, L.3
  • 26
    • 33846609195 scopus 로고    scopus 로고
    • Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and metaanalysis
    • Lorenz MW, Markus HS, Bots ML, et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and metaanalysis. Circulation. 2007;115:459-467.
    • (2007) Circulation , vol.115 , pp. 459-467
    • Lorenz, M.W.1    Markus, H.S.2    Bots, M.L.3
  • 27
    • 0032519844 scopus 로고    scopus 로고
    • The role of carotid arterial intima-media thickness in predicting clinical coronary events
    • Hodis H, Mack W, LaBree L, et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med. 1998;128: 262-269.
    • (1998) Ann Intern Med , vol.128 , pp. 262-269
    • Hodis, H.1    Mack, W.2    LaBree, L.3
  • 28
    • 77950327422 scopus 로고    scopus 로고
    • Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk
    • Nambi V, Chambless L, Folsom AR, et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk. J Am Coll Cardiol. 2010;55:1600-1607.
    • J Am Coll Cardiol. , vol.2010 , Issue.55 , pp. 1600-1607
    • Nambi, V.1    Chambless, L.2    Folsom, A.R.3
  • 29
    • 70350480977 scopus 로고    scopus 로고
    • In vivo quantification of carotid artery wall dimensions: 3.0-Tesla MRI versus B-mode ultrasound imaging
    • Duivenvoorden R, de Groot E, Elsen BM, et al. In vivo quantification of carotid artery wall dimensions: 3.0-Tesla MRI versus B-mode ultrasound imaging. Circ Cardiovasc Imaging. 2009;2:235-242.
    • (2009) Circ Cardiovasc Imaging , vol.2 , pp. 235-242
    • Duivenvoorden, R.1    De Groot, E.2    Elsen, B.M.3
  • 30
    • 14844283819 scopus 로고    scopus 로고
    • Atherosclerosis imaging using MR imaging: Current and emerging applications
    • Desai MY, Bleumke DA. Atherosclerosis imaging using MR imaging: Current and emerging applications. Magn Reson Imaging Clin N Am. 2005;13:171-180.
    • (2005) Magn Reson Imaging Clin N Am , vol.13 , pp. 171-180
    • Desai, M.Y.1    Bleumke, D.A.2
  • 31
    • 0037044418 scopus 로고    scopus 로고
    • Computed tomography and magnetic resonance imaging for noninvasive coronary angiography and plaque imaging: Current and potential future concepts
    • DOI 10.1161/01.CIR.0000034392.34211.FC
    • Fayad ZA, Fuster V, Nikolaou K, et al. Computed tomography and magnetic resonance imaging for noninvasive coronary angiography and plaque imaging: Current and potential future concepts. Circulation. 2002;106:2026-2034. (Pubitemid 35176312)
    • (2002) Circulation , vol.106 , Issue.15 , pp. 2026-2034
    • Fayad, Z.A.1    Fuster, V.2    Nikolaou, K.3    Becker, C.4
  • 32
    • 57449084685 scopus 로고    scopus 로고
    • Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: More clarity or confusion?
    • Stein EA. Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: More clarity or confusion? J Am Coll Cardiol. 2008;52:2206-2209.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 2206-2209
    • Stein, E.A.1
  • 33
    • 62649118779 scopus 로고    scopus 로고
    • ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: The CAPTIVATE randomized trial
    • Meuwese MC, Groot E, Duivenvoorden R, et al. ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: The CAPTIVATE randomized trial. JAMA. 2009;301:1131-1139.
    • (2009) JAMA , vol.301 , pp. 1131-1139
    • Meuwese, M.C.1    Groot, E.2    Duivenvoorden, R.3
  • 34
    • 50949102416 scopus 로고    scopus 로고
    • Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimibe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
    • Cannon CP, Giugliano RP, Blazing MA, et al. Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimibe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes. Am Heart J. 2008;156:826-832.
    • (2008) Am Heart J , vol.156 , pp. 826-832
    • Cannon, C.P.1    Giugliano, R.P.2    Blazing, M.A.3
  • 35
    • 78650776774 scopus 로고    scopus 로고
    • Atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides and impact on global health outcomes (AIM-HIGH) trial. Available at,Accessed January 19,2010
    • Atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides and impact on global health outcomes (AIM-HIGH) trial. Available at: Gttp://www.clinicaltrials.gov/ct/show/NCT00120289. Accessed January 19, 2010.
  • 36
    • 78650781470 scopus 로고    scopus 로고
    • Heart Protection Study 2: Treatment of HDL to reduce the incidence of vascular events (HPS2-THRIVE) trial.Available at: Accessed January 19,2010
    • Heart Protection Study 2: Treatment of HDL to reduce the incidence of vascular events (HPS2-THRIVE) trial. Available at: Gttp://www.clinicaltrials. gov/ct/ showNCT00461630. Accessed January 19, 2010.
  • 37
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • The ACCORD Study Group,10.1056/NEJMoa1001282
    • The ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362:1563-1574. doi: 10.1056/NEJMoa1001282.
    • (2010) N Engl J Med. , vol.362 , pp. 1563-1574


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.