The CIMESTRA study: Intra-articular glucocorticosteroids and synthetic DMARDs in a treat-to-target strategy in early rheumatoid arthritis

Clinical and Experimental Rheumatology

Volumn 30, Issue 4 SUPPL.73, 2012, Pages

  Hetland, M L ^a,b   Horslev Petersen K ^c,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Rheumatism Hospital   (Denmark)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

CIMESTRA study; Early rheumatoid arthritis; Synthetic DMARDs

Indexed keywords

BETAMETHASONE; CYCLOSPORIN; HYDROXYCHLOROQUINE; METHOTREXATE; SALAZOSULFAPYRIDINE;

ADULT; ARTICLE; DISEASE COURSE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; RHEUMATOID ARTHRITIS; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADULT; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CYCLOSPORINE; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FEMALE; GLUCOCORTICOIDS; HUMANS; HYDROXYCHLOROQUINE; INJECTIONS, INTRA-ARTICULAR; LONGITUDINAL STUDIES; MALE; METHOTREXATE; MIDDLE AGED; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 84870278563     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. HETLAND ML, STENGAARD-PEDERSEN K, JUNKER P et al.: Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator-initiated, multicenter, randomized, double-blind, parallel-group, placebo-controlled study. Arthritis Rheum 2006;54:1401-9.
2. HETLAND ML, STENGAARD-PEDERSEN K, JUNKER P et al.: Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study. Ann Rheum Dis 2008;67:815-22.
3. HETLAND ML, STENGAARD-PEDERSEN K, JUNKER P et al.: Radiographic progression and remission rates in early rheumatoid arthritis - MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial. Ann Rheum Dis 2010;69:1789-95.
4. HETLAND ML, EJBJERG B, HORSLEV-PETERSEN K et al.: MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA). Ann Rheum Dis 2009;68:384-90.
5. HETLAND ML, ØSTERGAARD M, EJBJERG B et al.: Short-and long-term effect of unguided, intra-articular injections with betamethasone as part of a treat to target strategy in early rheumatoid arthritis. Impact of joint area, repeated injections, MRI findings, anti-CCP, IgM-RF and CRP. Ann Rheum Dis 2012;71:851-6.
6. JACOBSEN S, GARRED P, MADSEN HO et al.: Mannose-binding lectin gene polymorphisms are associated with disease activity and physical disability in untreated, anti-CCP positive early rheumatoid arthritis patients. J Rheumatol 2009;36; 731-5.
7. LAURBERG TB, FRYSTYK J, ELLINGSEN T et al.: Plasma adiponectin in active, early, steroid-and DMARD-naïve as well as in chronic rheumatoid arthritis patients compared with osteoarthritis patients and healthy controls. J Rheumatol 2009;36 1885-91.
8. CHRISTENSEN AF, JUNKER P, LINDEGAARD H et al.: Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides. J Rheumatol 2010;37:1113-20.
9. CHRISTENSEN AF, SØRENSEN GL, HORSLEV-PETERSEN K et al.: Circulating surfactant protein-D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis. Arthritis Res Ther 2010;12:R39.
10. RASMUSSEN TK, ANDERSEN T, HVID M et al.: Increased IL-21 and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol 2010;37:2014-20.
11. + T-lymphocytes from active early steroid-and DMARD-nai've RA patients is up-regulated and not influenced by 1 year of clinically effective treatment. Rheumatol Int 2012;32:501-4.
12. CHRISTENSEN AF, LINDEGAARD H, HØRSLEV-PETERSEN K et al.: Cartilage oligomeric matrix protein (COMP) associates differentially with erosions and synovitis and has a different temporal course in early anti-CCP positive vs. anti-CCP negative rheumatoid arthritis patients. J Rheumatol 2011;38 1563-8.
13. GREISEN SR, MØLLER HJ, STENGAARD-PEDERSEN K et al. Soluble macrophage-derived CD 163 is a marker of disease activity and radiographic progression in early rheumatoid arthritis. Clin Exp Rheumatol 2011;29:689-92.
14. LANDEWÉ RB, BOERS M, VERHOEVEN AC et al.: COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum 2002;46:347-56.
15. KORPELA M, LAASONEN L, HANNONEN P et al.: Retardation of joint damage in patients with early rheumatoid arthritis by initial aggressive treatment with disease-modifying antirheumatic drugs: five-year experience from the FIN-RACo study. Arthritis Rheum 2004;50:2072-81.
16. ST CLAIR EW, VAN DER HEIJDE DM, SMOLEN JS et al.: Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial. Arthritis Rheum 2004;50:3432-43.
17. BREEDVELDF C, WEISMANM H, KAVANAUGH AF et al.: The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 2006;54:26-37.
18. EMERY P, BREEDVELD FC, HALL S et al.: Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial. Lancet 2008;372:375-82.
19. MAILLEFERT JF, COMBE B, GOUPILLE P, CANTAGREL A, DOUGADOS M: Long term structural effects of combination therapy in patients with early rheumatoid arthritis: five year follow up of a prospective double blind controlled study. Ann Rheum Dis 2003;62:764-6.
20. GRIGOR C, CAPELL H, STIRLING A et al.: Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 2004;364:263-9.
21. GOEKOOP-RUITERMAN YP, DE VRIES-BOUWSTRA JK, ALLAART CF et al.: Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum 2005;52:3381-90.
22. VERSTAPPEN SM, JACOBS JW, VAN D V M J et al.: Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis 2007;66:1443-9.
23. HETLAND ML: Modern treatment strategies in rheumatoid arthritis. Dan Med Bull 2011;58:B4320.