Cartilage oligomeric matrix protein associates differentially with erosions and synovitis and has a different temporal course in cyclic citrullinated peptide antibody (anti-CCP)-positive versus anti-CCP-negative early rheumatoid arthritis

Journal of Rheumatology

Volumn 38, Issue 8, 2011, Pages 1563-1568

  Christensen, Anne F ^a,e   Lindegaard, Hanne ^a,e   Hørslev Petersen, Kim ^d   Hetland, Merete L ^b   Ejbjerg, Bo ^b   Stengaard Pedersen, Kristian ^c   Jacobsen, Søren ^f   Lottenburger, Tine ^d   Ellingsen, Torkell ^c   Andersen, Lis S ^d   Hansen, Ib ^c   Skjødt, Henrik ^b   Pedersen, Jens K ^d   Lauridsen, Ulrik B ^b   Svendsen, Anders ^a,e   Tarp, Ulrik ^c   Pødenphant, Jan ^b   Østergaard, Mikkel ^b   Junker, Peter ^a,e  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b Mental Health Services CPH   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d King Christian the Xth Hospital   (Denmark)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^f GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Autoantibodies; Cartilage; Cartilage oligomeric matrix protein; Cyclic citrullinated peptide antibody; Rheumatoid arthritis; Synovitis

Indexed keywords

C REACTIVE PROTEIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; CYCLOSPORIN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLUCOCORTICOID; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN M; METHOTREXATE; PLACEBO; RHEUMATOID FACTOR;

ACUTE DISEASE; ADULT; AGED; ANTIBODY TITER; ARTICLE; BONE EROSION; CLINICAL ASSESSMENT TOOL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ACTIVITY; DISEASE ACTIVITY SCORE IN 28 JOINTS; DISEASE ASSOCIATION; EDEMA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; SYNOVITIS; VISUAL ANALOG SCALE;

ADULT; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CLINICAL TRIALS AS TOPIC; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GLYCOPROTEINS; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PEPTIDES, CYCLIC; QUESTIONNAIRES; SYNOVITIS;

EID: 79961108005     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.101241     Document Type: Article

References (31)

1. Di Cesare PE, Carlson CS, Stollerman ES, Chen FS, Leslie M, Perris R. Expression of cartilage oligomeric matrix protein by human synovium. FEBS Letters 1997;412:249-52. (Pubitemid 27310040)
2. Hecht JT, Deere M, Putnam E, Cole W, Vertel B, Chen H, et al. Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudochondroplasia musculoskeletal tissues. Matrix Biol 1998;17:269-78. (Pubitemid 28403341)
3. Oldberg A, Antonsson P, Lindblom K, Heinegard D. COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins. J Biol Chem 1992;267:22346-50.
4. Neidhardt M, Hauser N, Paulsson M, Di Cesare PE, Michel BA, Häuselmann HJ. Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation. Br J Rheumatol 1997;36:1151-60.
5. Forslind K, Eberhardt K, Jonsson A, Saxne T. Increased serum concentrations of cartilage oligomeric matrix protein. A prognostic marker in early rheumatoid arthritis. Rheumatology 1992;31:593-8.
6. Lindqvist E, Eberhardt K, Bendtzen K, Heinegard D, Saxne T. Prognostic laboratory makers of joint damage in rheumatoid arthritis. Ann Rheum Dis 2005;64:196-201. (Pubitemid 40193611)
7. Skoumal M, Kolarz G, Klingler A. Serum levels of cartilage oligomeric matrix protein. Scand J Rheumatol 2003;32:156-61.
8. Fex E, Eberhardt K, Saxne T. Tissue-derived macromolecules and markers of inflammation in serum in early rheumatoid arthritis: relationship to development of joint destruction in hands and feet. Br J Rheumatol 1997;36:1161-5.
9. Roux-Lombard P, Eberhardt K, Saxne T, Dayer JM, Wollheim FA. Cytokines, metalloproteinases, their inhibitors and cartilage oligomeric matrix protein: relationship to radiological progression and inflammation in early rheumatoid arthritis. A prospective 5-year study. Rheumatology 2001;40:544-51.
10. de Jong Z, Munneke M, Vilim V, Zwinderman AH, Kroon HM, Ronday HK, et al. Value of serum cartilage oligomeric matrix protein as a prognostic marker of large-joint damage in rheumatoid arthritis - data from the RAPIT study. Rheumatology 2008;47:868-71. (Pubitemid 351796375)
11. Turesson C, Bergstrøm U, Jacobsson LTH, Truedsson L, Berglund G, Saxne T. Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis. Ann Rheum Dis 2011;70:520-2.
12. Christensen AF, Hørslev-Petersen K, Christgau S, Lindegaard HM, Lottenburger T, Junker K, et al. Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides. J Rheumatol 2010;37:1113-20.
13. Hetland ML, Stengaard-Pedersen K, Junker P, Lottenburger T,Ellingsen T, Andersen LS, et al. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator initiated, multicenter, randomized, double blind, parallel group, placebo controlled study. Arthritis Rheum 2006;54:1401-9.
14. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24. (Pubitemid 18091653)
15. Thorsen H, Hansen TM, McKenna SP, Sørensen SF, Whalley D. Adaption into Danish of the Stanford Health Assessment Questionnaire (HAQ) and the Rheumatoid Arthritis Quality of Life Scale (RaQol). Scand J Rheumatol 2001;30:103-9. (Pubitemid 32250800)
16. Prevoo MLL, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LBA, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Arthritis Rheum 1995;38:44-8.
17. Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, et al. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995;38:727-35.
18. Hetland M, Stengaard-Pedersen K, Junker P, Østergaard M, Ejbjerg BJ, Jacobsen S. Radiographic progression and remission rates in early rheumatoid arthritis - MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial. Ann Rheum Dis 2010;69:1789-95.
19. Hetland M, Ejbjerg B, Horslev-Petersen K, Jacobsen S, Vestergaard A, Jurik AG, et al. MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2 year randomized controlled trial (CIMESTRA). Ann Rheum Dis 2009;68:384-90.
20. Østergaard M, Peterfy C, Conaghan P, McQueen F, Bird P, Ejbjerg B, et al. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. J Rheumatol 2003;30:1385-6. (Pubitemid 36666373)
21. Saxne T, Heinegård D. Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. Br J Rheumatol 1992;31:583-91.
22. Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, et al. Meta-analysis: Diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med 2007;146:797-808. (Pubitemid 351650500)
23. Høier-Madsen M, Nielsen LP, Møller S. Determination of IgM rheumatoid factors by enzyme-linked immunosorbent assay (ELISA). Ugeskr Laeger 1986;148:2018-21.
24. Vasiliauskiene L, Wiik A, Hoier-Madsen M. Prevalence and clinical significance of antikeratin antibodies and other serological markers in Lithuanian patients with rheumatoid arthritis. Ann Rheum Dis 2001;60:459-66. (Pubitemid 32417417)
25. Kimura A, Sasazuki T. Eleventh International Histocompatibility workshop reference protocol for the HLA DNA typing technique. In: Tsuji K, Aizawa M, Sasazuki M, editors. Oxford: Oxford University Press; 1992.
26. Hetland ML, Stengaard-Pedersen K, Junker P, Lottenburger T, Hansen I, Andersen LS, et al. Aggressive combination therapy with intraarticular glucocorticoid injections and conventional DMARDs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study. Ann Rheum Dis 2008;67:815-22. (Pubitemid 351829382)
27. Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 2006;116:961-73.
28. Lundberg K, Nijenhuis S, Vossenaar ER, Palmblad K, van Venrooij WJ, Klareskog L, et al. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res Ther 2005;7:R458-67.
29. van Lent PL, Grevers L, Lubberts E, de Vries TJ, Nabbe KC, Verbeek S, et al. Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: Uncoupling of cartilage damage from bone erosions and joint inflammation. Arthritis Rheum 2006;54:3868-77. (Pubitemid 44955889)
30. Halasz K, Kassner A, Morgelin M, Heinegard D. COMP acts as a catalyst in collagen fibrillogenesis. J Biol Chem 2007;282:31166-73. (Pubitemid 350044871)
31. Mann HH, Ozbek S, Engel J, Paulsson M, Wagener R. Interactions between the cartilage oligomeric matrix protein and matrilins: implications for matrix assembly and the pathogenesis of chondrodysplasias. J Biol Chem 2004;279:25294-8. (Pubitemid 38756782)