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Volumn 37, Issue 6, 2010, Pages 1113-1120

Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides

(23)  Christensen, Anne Friesgaard a   Hørslev Petersen, Kim h   Christgau, Stephan i   Lindegaard, Hanne Merete a   Lottenburger, Tine h   Junker, Kirsten b   Hetland, Merete Lund c   Stengaard Pedersen, Kristian g   Jacobsen, Søren d   Ellingsen, Torkell g   Andersen, Lis Smedegaard h   Hansen, Ib g   Skjødt, Henrik c   Pedersen, Jens Kristian h   Lauridsen, Ulrik Birk c   Svendsen, Anders Jørgen a   Tarp, Ulrik g   Pødenphant, Jan c   Heegaard, Niels H H e   Vestergaard, Aage f   more..


Author keywords

Autoantibodies; Cartilage; Collagen; Rheumatoid arthritis; Synovitis

Indexed keywords

BETAMETHASONE; CARBOXY TERMINAL TELOPEPTIDE; COLLAGEN TYPE 2; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; CYCLOSPORIN; METHOTREXATE;

EID: 77953208549     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: 10.3899/jrheum.091265     Document Type: Article
Times cited : (13)

References (46)
  • 2
    • 43049158205 scopus 로고    scopus 로고
    • Clinical identification and treatment of a rapidly progressing disease state in patients with rheumatoid arthritis
    • Emery P, McInnes IB, van Vollenhoven R, Kraan MC. Clinical identification and treatment of a rapidly progressing disease state in patients with rheumatoid arthritis. Rheumatology 2008;47:392-398
    • (2008) Rheumatology , vol.47 , pp. 392-398
    • Emery, P.1    McInnes, I.B.2    Van Vollenhoven, R.3    Kraan, M.C.4
  • 3
    • 10844287991 scopus 로고    scopus 로고
    • How to predict prognosis in early rheumatoid arthritis
    • Morel J, Combe B. How to predict prognosis in early rheumatoid arthritis. Best Pract Res Clin Rheumatol 2005;19:137-146
    • (2005) Best Pract Res Clin Rheumatol , vol.19 , pp. 137-146
    • Morel, J.1    Combe, B.2
  • 5
    • 0034121686 scopus 로고    scopus 로고
    • Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint disease
    • Garnero P, Rousseau JC, Delmas PD. Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint disease. Arthritis Rheum 2000;43:953-968
    • (2000) Arthritis Rheum , vol.43 , pp. 953-968
    • Garnero, P.1    Rousseau, J.C.2    Delmas, P.D.3
  • 6
    • 0034852317 scopus 로고    scopus 로고
    • Collagen type II C-telopeptide fragments as an index of cartilage degradation
    • Christgau S, Garnero P, Fledelius C, Moniz C, Ensig M, Gineyts E, et al. Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 2001;29:209-215
    • (2001) Bone , vol.29 , pp. 209-215
    • Christgau, S.1    Garnero, P.2    Fledelius, C.3    Moniz, C.4    Ensig, M.5    Gineyts, E.6
  • 7
    • 0036159153 scopus 로고    scopus 로고
    • Association of baseline levels of urinary glucosyl-galactosyl- pyrodinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis
    • Garnero P, Gineyts E, Christgau S, Finck B, Delmas PD. Association of baseline levels of urinary glucosyl-galactosyl-pyrodinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis. Arthritis Rheum 2002;46:21-30.
    • (2002) Arthritis Rheum , vol.46 , pp. 21-30
    • Garnero, P.1    Gineyts, E.2    Christgau, S.3    Finck, B.4    Delmas, P.D.5
  • 8
    • 35348910957 scopus 로고    scopus 로고
    • Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers
    • Young-Min S, Cawston TE, Marshall N, Coady D, Christgau S, Saxne T, et al. Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers. Arthritis Rheum 2007;56:3236-3247
    • (2007) Arthritis Rheum , vol.56 , pp. 3236-3247
    • Young-Min, S.1    Cawston, T.E.2    Marshall, N.3    Coady, D.4    Christgau, S.5    Saxne, T.6
  • 9
    • 0036846269 scopus 로고    scopus 로고
    • Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: The COBRA study
    • Garnero P, Landewe R, Boers M, Verhoeven A, Van Der Linden S, Christgau S, et al. Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study. Arthritis Rheum 2002;46:2847-2856
    • (2002) Arthritis Rheum , vol.46 , pp. 2847-2856
    • Garnero, P.1    Landewe, R.2    Boers, M.3    Verhoeven, A.4    Van Der Linden, S.5    Christgau, S.6
  • 10
    • 0021808867 scopus 로고
    • Enzymes converting procollagens to collagens
    • Peltonen L, Halila R, Ryhänen L. Enzymes converting procollagens to collagens. J Cell Biochem 1985;28:15-21.
    • (1985) J Cell Biochem , vol.28 , pp. 15-21
    • Peltonen, L.1    Halila, R.2    Ryhänen, L.3
  • 11
    • 0025346774 scopus 로고
    • Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA
    • Ryan MC, Sandell LJ. Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA. J Biol Chem 1990;265:10334-10339 (Pubitemid 20212757)
    • (1990) Journal of Biological Chemistry , vol.265 , Issue.18 , pp. 10334-10339
    • Ryan, M.C.1    Sandell, L.J.2
  • 12
    • 0029078901 scopus 로고
    • Tissue-specific and differential expression of alternatively spliced alpha1(II) collagen mRNAs in early human embryos
    • Lui V, Ng J, Nicholls J, Tam P, Cheah K. Tissue-specific and differential expression of alternatively spliced alpha1(II) collagen mRNAs in early human embryos. Dev Dyn 1995;203:198-211.
    • (1995) Dev Dyn , vol.203 , pp. 198-211
    • Lui, V.1    Ng, J.2    Nicholls, J.3    Tam, P.4    Cheah, K.5
  • 13
  • 14
    • 0025948422 scopus 로고
    • Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: Differential expression of the amino-propeptide
    • Sandell LJ, Morris N, Robbins JR, Goldring MB. Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide. J Cell Biol 1991;114:1307-1319 (Pubitemid 21909888)
    • (1991) Journal of Cell Biology , vol.114 , Issue.6 , pp. 1307-1319
    • Sandell, L.J.1    Morris, N.2    Robbins, J.R.3    Goldring, M.B.4
  • 15
    • 0035082264 scopus 로고    scopus 로고
    • Type IIA procollagen in development of the human intervertebral disc: Regulated expression of the NH2-propeptide by enzymic processing reveals a unique developmental pathway
    • Zhu Y, McAlinden A, Sandell LJ. Type IIA procollagen in development of the human intervertebral disc: Regulated expression of the NH2-propeptide by enzymic processing reveals a unique developmental pathway. Dev Dyn 2001;220:350-362
    • (2001) Dev Dyn , vol.220 , pp. 350-362
    • Zhu, Y.1    McAlinden, A.2    Sandell, L.J.3
  • 16
    • 0033535331 scopus 로고    scopus 로고
    • Type IIA Procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta 1 and BMP-2
    • Zhu Y, Oganesian A, Keene DR, Sandell LJ. Type IIA Procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta 1 and BMP-2. J Cell Biol 1999;144:1069-1080
    • (1999) J Cell Biol , vol.144 , pp. 1069-1080
    • Zhu, Y.1    Oganesian, A.2    Keene, D.R.3    Sandell, L.J.4
  • 17
    • 0033503715 scopus 로고    scopus 로고
    • Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage
    • Aigner T, Zhu Y, Chansky HH, Matsen FA, Maloney WJ, Sandell LJ. Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage. Arthritis Rheum 1999;42:1443-1450
    • (1999) Arthritis Rheum , vol.42 , pp. 1443-1450
    • Aigner, T.1    Zhu, Y.2    Chansky, H.H.3    Matsen, F.A.4    Maloney, W.J.5    Sandell, L.J.6
  • 18
    • 0036822532 scopus 로고    scopus 로고
    • Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis
    • Garnero P, Ayral X, Rousseau JC, Christgau S, Sandell LJ, Dougados M, et al. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum 2002;46:2613-2624
    • (2002) Arthritis Rheum , vol.46 , pp. 2613-2624
    • Garnero, P.1    Ayral, X.2    Rousseau, J.C.3    Christgau, S.4    Sandell, L.J.5    Dougados, M.6
  • 19
    • 67249086422 scopus 로고    scopus 로고
    • Differential association of the N-propeptide of collagen IIA (PIIANP) and the collagen II C-telopeptide (CTX-II) with synovitis and erosions in early and longstanding rheumatoid arthritis
    • Christensen AF, Lottenburger T, Lindegaard H, Christgau S, Hørslev-Petersen K, Junker P. Differential association of the N-propeptide of collagen IIA (PIIANP) and the collagen II C-telopeptide (CTX-II) with synovitis and erosions in early and longstanding rheumatoid arthritis. Clin Exp Rheumatol 2009;27:307-314
    • (2009) Clin Exp Rheumatol , vol.27 , pp. 307-314
    • Christensen, A.F.1    Lottenburger, T.2    Lindegaard, H.3    Christgau, S.4    Hørslev-Petersen, K.5    Junker, P.6
  • 20
    • 2542551882 scopus 로고    scopus 로고
    • Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis
    • Rousseau JC, Zhu Y, Miossec P, Vignon E, Sandell LJ, Garnero P, et al. Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartilage 2004;12:440-447
    • (2004) Osteoarthritis Cartilage , vol.12 , pp. 440-447
    • Rousseau, J.C.1    Zhu, Y.2    Miossec, P.3    Vignon, E.4    Sandell, L.J.5    Garnero, P.6
  • 21
    • 33645511657 scopus 로고    scopus 로고
    • Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
    • Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 2006;116:961-973
    • (2006) J Clin Invest , vol.116 , pp. 961-973
    • Kuhn, K.A.1    Kulik, L.2    Tomooka, B.3    Braschler, K.J.4    Arend, W.P.5    Robinson, W.H.6
  • 22
    • 33646468228 scopus 로고    scopus 로고
    • Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: An investigator-initiated, multicenter, randomized, double-blind, parallel-group, placebo-controlled study
    • Hetland ML, Stengaard-Pedersen K, Junker P, Lottenburger T, Ellingsen T, Andersen LS, et al. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator-initiated, multicenter, randomized, double-blind, parallel-group, placebo-controlled study. Arthritis Rheum 2006;54:1401-1409
    • (2006) Arthritis Rheum , vol.54 , pp. 1401-1409
    • Hetland, M.L.1    Stengaard-Pedersen, K.2    Junker, P.3    Lottenburger, T.4    Ellingsen, T.5    Andersen, L.S.6
  • 23
    • 45149113632 scopus 로고    scopus 로고
    • Aggressive combination therapy with intraarticular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: Second-year clinical and radiographic results from the CIMESTRA Study
    • Hetland ML, Stengaard-Pedersen K, Junker P, Lottenburger T, Hansen I, Andersen LS, et al. Aggressive combination therapy with intraarticular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA Study. Ann Rheum Dis 2008;67:815-822
    • (2008) Ann Rheum Dis , vol.67 , pp. 815-822
    • Hetland, M.L.1    Stengaard-Pedersen, K.2    Junker, P.3    Lottenburger, T.4    Hansen, I.5    Andersen, L.S.6
  • 24
    • 0023945481 scopus 로고    scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-324
    • Arthritis Rheum , vol.1988 , Issue.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 25
    • 0035083845 scopus 로고    scopus 로고
    • Adaption into Danish of the Stanford Health Assessment Questionnaire (HAQ) and the Rheumatoid Arthritis Quality of Life Scale (RaQol)
    • Thorsen H, Hansen TM, McKenna SP, Sørensen SF, Whalley D. Adaption into Danish of the Stanford Health Assessment Questionnaire (HAQ) and the Rheumatoid Arthritis Quality of Life Scale (RaQol). Scand J Rheumatol 2001;30:103-109
    • (2001) Scand J Rheumatol , vol.30 , pp. 103-109
    • Thorsen, H.1    Hansen, T.M.2    McKenna, S.P.3    Sørensen, S.F.4    Whalley, D.5
  • 27
    • 0033984107 scopus 로고    scopus 로고
    • How to read radiographs according to Sharp/van der Heijde method
    • van der Heijde D. How to read radiographs according to Sharp/van der Heijde method. J Rheumatol 2000;27:261-263
    • (2000) J Rheumatol , vol.27 , pp. 261-263
    • Van Der Heijde, D.1
  • 29
    • 34447339916 scopus 로고    scopus 로고
    • A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis - Association with disease progression
    • Sharif M, Kirwan J, Charni N, Sandell LJ, Whittles C, Garnero P. A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis - association with disease progression. Rheumatology 2007;46:938-943
    • (2007) Rheumatology , vol.46 , pp. 938-943
    • Sharif, M.1    Kirwan, J.2    Charni, N.3    Sandell, L.J.4    Whittles, C.5    Garnero, P.6
  • 30
    • 0037377954 scopus 로고    scopus 로고
    • Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: Influence of age, sex, menopause, hormone replacement therapy, and body mass index
    • Mouritzen U, Christgau S, Lehmann HJ, Tanko LB, Christiansen C. Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 2003;62:332-336
    • (2003) Ann Rheum Dis , vol.62 , pp. 332-336
    • Mouritzen, U.1    Christgau, S.2    Lehmann, H.J.3    Tanko, L.B.4    Christiansen, C.5
  • 31
    • 0023041471 scopus 로고
    • Determination of IgM rheumatoid factors by enzyme-linked immunosorbent assay (ELISA)
    • Høier-Madsen M, Nielsen LP, Møller S. Determination of IgM rheumatoid factors by enzyme-linked immunosorbent assay (ELISA). Ugeskr Laeger 1986;148:2018-2021
    • (1986) Ugeskr Laeger , vol.148 , pp. 2018-2021
    • Høier-Madsen, M.1    Nielsen, L.P.2    Møller, S.3
  • 32
    • 0035015501 scopus 로고    scopus 로고
    • Prevalence and clinical significance of antikeratin antibodies and other serological markers in Lithuanian patients with rheumatoid arthritis
    • Vasiliauskiene L, Wiik A, Hoier-Madsen M. Prevalence and clinical significance of antikeratin antibodies and other serological markers in Lithuanian patients with rheumatoid arthritis. Ann Rheum Dis 2001;60:459-466
    • (2001) Ann Rheum Dis , vol.60 , pp. 459-466
    • Vasiliauskiene, L.1    Wiik, A.2    Hoier-Madsen, M.3
  • 33
    • 34250626806 scopus 로고    scopus 로고
    • Meta-analysis: Diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis
    • Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med 2007;146:797-808.
    • (2007) Ann Intern Med , vol.146 , pp. 797-808
    • Nishimura, K.1    Sugiyama, D.2    Kogata, Y.3    Tsuji, G.4    Nakazawa, T.5    Kawano, S.6
  • 35
    • 61549139043 scopus 로고    scopus 로고
    • MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA)
    • Hetland M, Ejbjerg B, Horslev-Petersen K, Jacobsen S, Vestergaard A, Jurik AG, et al. MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA). Ann Rheum Dis 2009;68:384-390
    • (2009) Ann Rheum Dis , vol.68 , pp. 384-390
    • Hetland, M.1    Ejbjerg, B.2    Horslev-Petersen, K.3    Jacobsen, S.4    Vestergaard, A.5    Jurik, A.G.6
  • 36
    • 0027328906 scopus 로고
    • Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption
    • Eastell R, Robins SP, Colwell T, Assiri AMA, Riggs BL, Russell RG. Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption. Osteoporos Int 1993;3:255-260 (Pubitemid 23252444)
    • (1993) Osteoporosis International , vol.3 , Issue.5 , pp. 255-260
    • Eastell, R.1    Robins, S.P.2    Colwell, T.3    Assiri, A.M.A.4    Riggs, B.L.5    Russell, R.G.G.6
  • 37
    • 27744515706 scopus 로고    scopus 로고
    • Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
    • Lundberg K, Nijenhuis S, Vossenaar ER, Palmblad K, van Venrooij WJ, Klareskog L, et al. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res Ther 2005;7:R458-67.
    • (2005) Arthritis Res Ther , vol.7
    • Lundberg, K.1    Nijenhuis, S.2    Vossenaar, E.R.3    Palmblad, K.4    Van Venrooij, W.J.5    Klareskog, L.6
  • 38
    • 67650065027 scopus 로고    scopus 로고
    • Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
    • Trouw LA, Haisma EM, Levarht EW, van der Woude D, Ioan-Facsinay A, Daha MR, et al. Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum 2009;60:1923-1931
    • (2009) Arthritis Rheum , vol.60 , pp. 1923-1931
    • Trouw, L.A.1    Haisma, E.M.2    Levarht, E.W.3    Van Der Woude, D.4    Ioan-Facsinay, A.5    Daha, M.R.6
  • 39
    • 0033118675 scopus 로고    scopus 로고
    • From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
    • Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451-461
    • (1999) Immunity , vol.10 , pp. 451-461
    • Korganow, A.S.1    Ji, H.2    Mangialaio, S.3    Duchatelle, V.4    Pelanda, R.5    Martin, T.6
  • 41
    • 60649104354 scopus 로고    scopus 로고
    • Collagen antibody-induced arthritis in mice Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies
    • Hutamekalin P, Saito T, Yamaki K, Mizutani N, Brand DD, Waritani T, et al. Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies. J Immunol Methods 2009;343:49-55.
    • (2009) J Immunol Methods , vol.343 , pp. 49-55
    • Hutamekalin, P.1    Saito, T.2    Yamaki, K.3    Mizutani, N.4    Brand, D.D.5    Waritani, T.6
  • 42
    • 0345827529 scopus 로고    scopus 로고
    • The synovium in rheumatoid arthritis: Evidence for (at least) two pathologies
    • Kirwan JR. The synovium in rheumatoid arthritis: evidence for (at least) two pathologies. Arthritis Rheum 2004;50:1-4.
    • (2004) Arthritis Rheum , vol.50 , pp. 1-4
    • Kirwan, J.R.1
  • 44
    • 3442875303 scopus 로고    scopus 로고
    • Pathogenesis of bone and cartilage destruction in rheumatoid arthritis
    • Goldring SR. Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology 2003;42 Suppl 2:ii11-6.
    • (2003) Rheumatology , vol.42 , Issue.SUPPL. 2
    • Goldring, S.R.1
  • 45
    • 33845482745 scopus 로고    scopus 로고
    • A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness
    • xi-xiii, 1-229
    • Chen YF, Jobanputra P, Barton P, Jowett S, Bryan S, Clark W, et al. A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness. Health Technol Assess 2006;10:iii-iv, xi-xiii, 1-229.
    • (2006) Health Technol Assess , vol.10
    • Chen, Y.F.1    Jobanputra, P.2    Barton, P.3    Jowett, S.4    Bryan, S.5    Clark, W.6
  • 46
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • Cohen SB, Emery P, Greenwald MW, Dougados M, Furie RA, Genovese MC, et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006;54:2793-2806
    • (2006) Arthritis Rheum , vol.54 , pp. 2793-2806
    • Cohen, S.B.1    Emery, P.2    Greenwald, M.W.3    Dougados, M.4    Furie, R.A.5    Genovese, M.C.6


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