A new route to Roflumilast via copper-catalyzed hydroxylation

Synthesis (Germany)

Volumn 44, Issue 23, 2012, Pages 3598-3602

  Ni, Feng ^a,b   Li, Jianqi ^a,b  

^a SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

^b Shanghai Engineering Research Center of Pharmaceutical Process   (China)

Author keywords

copper catalyzed; hydroxylation; PDE4 inhibitor; preparation; Roflumiast

Indexed keywords

BENZOIC ACID; COPPER CATALYZED; PDE4 INHIBITOR; PHOSPHODIESTERASES; PREPARATION; ROFLUMIAST; SYNTHETIC PROCEDURES;

AMIDES; CARBOXYLIC ACIDS; CATALYSIS; HYDROXYLATION;

COPPER;

3 (CYCLOPROPYLMETHOXY) 4 (DIFLUOROMETHOXY)BENZOIC ACID; 3 (CYCLOPROPYLMETHOXY) 4 HYDROXYBENZOIC ACID; 4 HYDROXY 3 IODOBENZOIC ACID; METHYL 3 (CYCLOPROPYLMETHOXY) 4 (DIFLUOROMETHOXY)BENZOIC ACID; METHYL 3 (CYCLOPROPYLMETHOXY) 4 HYDROXYBENZOIC ACID; METHYL 3 (CYCLOPROPYLMETHOXY) 4 IODOBENZOIC ACID; NYCOMED; ROFLUMILAST; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH RESOLUTION MELTING ANALYSIS; INFRARED SPECTROSCOPY; MELTING POINT; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME;

EID: 84870250198     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1317527     Document Type: Article

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