Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7363-7366

  Yu, Melvin J ^a   Zheng, Wanjun ^a   Tendyke, Karen ^a  

^a EISAI INC   (United States)

Author keywords

Enumeration; Eribulin; Halaven; P glycoprotein

Indexed keywords

ERIBULIN; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; CELL GROWTH; COMPUTER MODEL; DRUG SENSITIVITY; DRUG STRUCTURE; GENETIC ALGORITHM; GROWTH INHIBITION; SURVIVAL;

ALGORITHMS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FURANS; HUMANS; KETONES; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870242794     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.077     Document Type: Article

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