Novel second generation analogs of eribulin. Part III: Blood-brain barrier permeability and in vivo activity in a brain tumor model

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1639-1643

  Narayan, Sridhar ^a   Carlson, Eric M ^a   Cheng, Hongsheng ^a   Condon, Krista ^a   Du, Hong ^a   Eckley, Sean ^a   Hu, Yongbo ^a   Jiang, Yimin ^a   Kumar, Vipul ^a   Lewis, Bryan M ^a   Saxton, Philip ^a   Schuck, Edgar ^a   Seletsky, Boris M ^a   Tendyke, Karen ^a   Zhang, Huiming ^a   Zheng, Wanjun ^a   Littlefield, Bruce A ^a,b   Towle, Murray J ^a   Yu, Melvin J ^a  

^a EISAI INC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antitumor agents; Blood brain barrier permeability; Glioblastoma; Microtubule; Multi drug resistance; Orthotopic brain tumor models; P Glycoprotein

Indexed keywords

ANTINEOPLASTIC AGENT; ERIBULIN; ERIBULIN DERIVATIVE; GLYCOPROTEIN P; HALAVEN; PACLITAXEL; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; GLIOBLASTOMA; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PHYSICAL CHEMISTRY; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FURANS; INHIBITORY CONCENTRATION 50; KETONES; MICE; MICE, INBRED BALB C;

MURINAE; MUS;

EID: 79952363770     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.096     Document Type: Article

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