7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7518-7522

  Cheung, Adrian Wai Hing ^a   Banner, Bruce ^a   Bose, Jolly ^a   Kim, Kyungjin ^a   Li, Shiming ^a   Marcopulos, Nicholas ^a   Orzechowski, Lucja ^a   Sergi, Joseph A ^a   Thakkar, Kshitij C ^a   Wang, Bing Bing ^a   Yun, Weiya ^a   Zwingelstein, Catherine ^a   Berthel, Steven ^a   Olivier, Andrée R ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Pharmacokinetic; Phosphatase selectivity; Protein tyrosine phosphatase; PTP1B inhibitor

Indexed keywords

7 PHENYL PYRIDO[2,3 D]PYRIMIDINE 2,4 DIAMINE DERIVATIVE; DIAMINE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN;

ANIMALS; DIAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870240968     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.035     Document Type: Article

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