Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7555-7561

  Lee, Yun Suk ^a,b   Kim, Hee ^c   Kim, Young Ho ^c   Roh, Eun Joo ^a   Han, Hogyu ^b   Shin, Kye Jung ^d  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c Medifron DBT   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

Amyloid; Alzheimer's disease; NF B; RAGE antagonist

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; BENZONITRILE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; THIAZOLE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; DRUG SYNTHESIS; INFLAMMATION; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, IMMUNOLOGIC; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84870238175     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.022     Document Type: Article

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