Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase i inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7486-7489

  Chiba, Takashi ^a   Ohwada, Jun ^a   Sakamoto, Hiroshi ^a   Kobayashi, Takamitsu ^a   Fukami, Takaaki A ^a   Irie, MacHiko ^a   Miura, Takaaki ^a   Ohara, Kazuhiro ^a   Koyano, Hiroshi ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

7 Azaindole; Glyoxalase I (GLO1); N Hydroxypyridone; Structure based drug design (SBDD)

Indexed keywords

ENZYME INHIBITOR; GLUTATHIONE DERIVATIVE; GLYOXALASE; INDOLE DERIVATIVE; OXYGEN; PYRIDONE DERIVATIVE;

ARTICLE; CHEMICAL INTERACTION; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG DESIGN; ENZYME INHIBITION; EVALUATION; HIGH THROUGHPUT SCREENING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDOLES; LACTOYLGLUTATHIONE LYASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870237988     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.045     Document Type: Article

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