Inhibition of osteoclast generation: A novel function of the bone morphogenetic protein 7/osteogenic protein 1

Mediators of Inflammation

Volumn 2012, Issue , 2012, Pages

  Maurer, Thomas ^a   Zimmermann, Gerald ^a   Maurer, Susanne ^a   Stegmaier, Sabine ^a   Wagner, Christof ^a   Hänsch, G Maria ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOGENIC PROTEIN 1; PROTEIN C FOS; TRANSCRIPTION FACTOR MAFB; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; NFATC1 PROTEIN, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CELL TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MACROPHAGE; MONOCYTE; NORMAL HUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIGENS, CD14; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 7; CELL DIFFERENTIATION; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-8; MONOCYTES; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS C-FOS; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84870231775     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2012/171209     Document Type: Article

References (44)

1. Al-Aql Z. S., Alagl A. S., Graves D. T., Gerstenfeld L. C., Einhorn T. A., Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. Journal of Dental Research 2008 87 2 107 118 2-s2.0-39149143035 10.1177/154405910808700215
2. Koide M., Kinugawa S., Takahashi N., Udagawa N., Osteoclastic bone resorption induced by innate immune responses. Periodontology 2000 2010 54 1 235 246 2-s2.0-77955737375 10.1111/j.1600-0757.2010.00355.x
3. Irfan U. M., Dawson D. V., Bissada N. F., Epidemiology of periodontal disease: a review and clinical perspectives. Journal of the International Academy of Periodontology 2001 3 1 14 21 2-s2.0-0035241498
4. Hunter D. J., Sambrook P. N., Bone loss: epidemiology of bone loss. Arthritis Research 2000 2 6 441 445 2-s2.0-0034469587 10.1186/ar125 (Pubitemid 32223785)
5. Henderson B., Nair S. P., Hard labour: bacterial infection of the skeleton. Trends in Microbiology 2003 11 12 570 577 2-s2.0-0344628647 10.1016/j.tim.2003.10.005 (Pubitemid 37500908)
6. Waldvogel F. A., Medoff G., Swartz M. N., Treatment of osteomyelitis. New England Journal of Medicine 1970 283 15 822 2-s2.0-0014937428
7. Wagner C., Obst U., Hänsch G. M., Implant-associated posttraumatic osteomyelitis: collateral damage by local host defense? International Journal of Artificial Organs 2005 28 11 1172 1180 2-s2.0-30644480847 (Pubitemid 43085410)
8. Jeffcoate W. J., Game F., Cavanagh P. R., The role of proinflammatory cytokines in the cause of neuropathic osteoarthropathy (acute Charcot foot) in diabetes. The Lancet 2005 366 9502 2058 2061 2-s2.0-28844483877 10.1016/S0140-6736(05)67029-8 (Pubitemid 41773381)
9. Gaida M. M., Mayer B., Stegmaier S., Schirmacher P., Wagner C., Hänsch G. M., Polymorphonuclear neutrophils in osteomyelitis: link to osteoclast generation and bone resorption. European Journal of Inflammation. In press
10. Kim Y., Sato K., Asagiri M., Morita I., Soma K., Takayanagi H., Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. Journal of Biological Chemistry 2005 280 38 32905 32913 2-s2.0-25444444351 10.1074/jbc.M505820200 (Pubitemid 41368340)
11. Yamashita T., Yao Z., Li F., Zhang Q., Badell I. R., Schwarz E. M., Takeshita S., Wagner E. F., Noda M., Matsuo K., Xing L., Boyce B. F., NF- κ B p50 and p52 regulate receptor activator of NF- κ B ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. Journal of Biological Chemistry 2007 282 25 18245 18253 2-s2.0-34547124586 10.1074/jbc.M610701200 (Pubitemid 47100255)
12. Matsuo K., Galson D. L., Zhao C., Peng L., Laplace C., Wang K. Z. Q., Bachler M. A., Amano H., Aburatani H., Ishikawa H., Wagner E. F., Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. Journal of Biological Chemistry 2004 279 25 26475 26480 2-s2.0-2942731511 10.1074/jbc.M313973200 (Pubitemid 38798801)
13. Takayanagi H., The role of NFAT in osteoclast formation. Annals of the New York Academy of Sciences 2007 1116 227 237 2-s2.0-37249090188 10.1196/annals.1402.071 (Pubitemid 350274348)
14. Ikeda F., Nishimura R., Matsubara T., Hata K., Reddy S. V., Yoneda T., Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity. Journal of Immunology 2006 177 4 2384 2390 2-s2.0-33746882463 (Pubitemid 44200999)
15. Nishikawa K., Nakashima T., Hayashi M., Fukunaga T., Kato S., Kodama T., Takahashi S., Calame K., Takayanagi H., Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proceedings of the National Academy of Sciences of the United States of America 2010 107 7 3117 3122 2-s2.0-77649262903 10.1073/pnas.0912779107
16. Kelly L. M., Englmeier U., Lafon I., Sieweke M. H., Graf T., MafB is an inducer of monocytic differentiation. EMBO Journal 2000 19 9 1987 1997 2-s2.0-0034595223 (Pubitemid 30237574)
17. Kim K., Jung H. K., Lee J., Hye M. J., Kook H., Kyung K. K., Soo Y. L., Kim N., MafB negatively regulates RANKL-mediated osteoclast differentiation. Blood 2007 109 8 3253 3259 2-s2.0-34147132897 10.1182/blood-2006-09-048249 (Pubitemid 46572510)
18. Smink J. J., Bégay V., Schoenmaker T., Sterneck E., De Vries T. J., Leutz A., Transcription factor C/EBP β isoform ratio regulates osteoclastogenesis through MafB. EMBO Journal 2009 28 12 1769 1781 2-s2.0-67649562301 10.1038/emboj.2009.127
19. Shen B., Wei A., Whittaker S., Williams L. A., Tao H., Ma D. D. F., Diwan A. D., The role of BMP-7 in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in vitro. Journal of Cellular Biochemistry 2010 109 2 406 416 2-s2.0-74949118565 10.1002/jcb.22412
20. Wang E. A., Rosen V., D'Alessandro J. S., Bauduy M., Cordes P., Harada T., Israel D. I., Hewick R. M., Kerns K. M., LaPan P., Luxenberg D. P., McQuaid D., Moutsatsos I. K., Nove J., Wozney J. M., Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences of the United States of America 1990 87 6 2220 2224 2-s2.0-0025216220
21. Perron J. C., Dodd J., ActRIIA and BMPRII type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis. PLoS ONE 2009 4 12 2-s2.0-77949526904 10.1371/journal.pone.0008198 e8198
22. Macías-Silva M., Hoodless P. A., Tang S. J., Buchwald M., Wrana J. L., Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. Journal of Biological Chemistry 1998 273 40 25628 25636 2-s2.0-0032475884 10.1074/jbc.273.40.25628 (Pubitemid 28475783)
23. Greenwald J., Groppe J., Gray P., Wiater E., Kwiatkowski W., Vale W., Choe S., The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Molecular Cell 2003 11 3 605 617 2-s2.0-0037351880 10.1016/S1097-2765(03)00094-7 (Pubitemid 36385117)
24. Lavery K., Hawley S., Swain P., Rooney R., Falb D., Alaoui-Ismaili M. H., New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells. Bone 2009 45 1 27 41 2-s2.0-67349155526 10.1016/j.bone.2009.03.656
25. Shea C. M., Edgar C. M., Einhorn T. A., Gerstenfeld L. C., BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. Journal of Cellular Biochemistry 2003 90 6 1112 1127 2-s2.0-0344011669 10.1002/jcb.10734 (Pubitemid 37485049)
26. Geesink R. G. T., Hoefnagels N. H. M., Bulstra S. K., Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. Journal of Bone and Joint Surgery Series B 1999 81 4 710 718 2-s2.0-0032728667 10.1302/0301-620X.81B4.9311
27. Donati D., Bella C. D., Lucarelli E., Dozza B., Frisoni T., Aldini N. N., Giardino R., OP-1 application in bone allograft integration: preliminary results in sheep experimental surgery. Injury 2008 39 supplement 2 S65 S72 2-s2.0-51649108090 10.1016/S0020-1383(08)70017-2
28. Zimmermann G., Moghaddam A., Wagner C., Vock B., Wentzensen A., Clinical experience with bone morphogenetic protein 7 (BMP 7) in nonunions of long bones. Unfallchirurg 2006 109 7 528 537 2-s2.0-33746238188 10.1007/s00113-006-1078-5 (Pubitemid 44090434)
29. Garrison K. R., Shemilt I., Donell S., Ryder J. J., Mugford M., Harvey I., Song F., Alt V., Bone morphogenetic protein (BMP) for fracture healing in adults. Cochrane Database of Systematic Reviews 2010 6 CD006950 2-s2.0-77954963937
30. Den Boer F. C., Bramer J. A. M., Blokhuis T. J., Van Soest E. J., Jenner J. M. G. T., Patka P., Bakker F. C., Burger E. H., Haarman H. J. T. M., Effect of recombinant human osteogenic protein-1 on the healing of a freshly closed diaphyseal fracture. Bone 2002 31 1 158 164 2-s2.0-0036309478 10.1016/S8756-3282(02)00816-5 (Pubitemid 34754442)
31. Lakkakorpi P. T., Vaananen H. K., Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro. Journal of Bone and Mineral Research 1991 6 8 817 826 2-s2.0-0026042067
32. Asagiri M., Sato K., Usami T., Ochi S., Nishina H., Yoshida H., Morita I., Wagner E. F., Mak T. W., Serfling E., Takayanagi H., Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. Journal of Experimental Medicine 2005 202 9 1261 1269 2-s2.0-27744432009 10.1084/jem.20051150 (Pubitemid 41586956)
33. Hentunen T. A., Lakkakorpi P. T., Tuukkanen J., Lehenkari P. P., Sampath T. K., Väänänen H. K., Effects of recombinant human osteogenic protein-1 on the differentiation of osteoclast-like cells and bone resorption. Biochemical and Biophysical Research Communications 1995 209 2 433 443 2-s2.0-0028961052 10.1006/bbrc.1995.1521
34. Zheng Y., Wang L., Zhang X., Gu Z., Wu G., BMP2/7 heterodimer can modulate all cellular events of the in vitro RANKL-mediated osteoclastogenesis, respectively, in different dose patterns. Tissue Engineering Part A 2012 18 5-6 621 630 10.1089/ten.tea.2011.0366
35. Hsu H., Lacey D. L., Dunstan C. R., Solovyev I., Colombero A., Timms E., Tan H. L., Elliott G., Kelley M. J., Sarosi I., Wang L., Xia X. Z., Elliott R., Chiu L., Black T., Scully S., Capparelli C., Morony S., Shimamoto G., Bass M. B., Boyle W. J., Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proceedings of the National Academy of Sciences of the United States of America 1999 96 7 3540 3545 2-s2.0-13044316551 10.1073/pnas.96.7.3540 (Pubitemid 29168945)
36. Kong Y. Y., Yoshida H., Sarosi I., Tan H. L., Timms E., Capparelli C., Morony S., Oliveira-dos-Santos A. J., Van G., Itie A., Khoo W., Wakeham A., Dunstan C. R., Lacey D. L., Mak T. W., Boyle W. J., Penninger J. M., OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999 397 6717 315 323 2-s2.0-0033611467 10.1038/16852 (Pubitemid 29061638)
37. Evans K. E., Fox S. W., Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus. BMC Cell Biology 2007 8, article 4 2-s2.0-33846785197 10.1186/1471-2121-8-4 (Pubitemid 46210959)
38. Mohamed S. G. K., Sugiyama E., Shinoda K., Taki H., Hounoki H., Abdel-Aziz H. O., Maruyama M., Kobayashi M., Ogawa H., Miyahara T., Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. Bone 2007 41 4 592 602 2-s2.0-34548533322 10.1016/j.bone.2007.05.016 (Pubitemid 47385426)
39. Sieweke M. H., Tekotte H., Frampton J., Graf T., MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell 1996 85 1 49 60 2-s2.0-0029870839 10.1016/S0092-8674(00)81081-8 (Pubitemid 26116806)
40. Seta N., Okazaki Y., Kuwana M., Human circulating monocytes can express receptor activator of nuclear factor- κ B ligand and differentiate into functional osteoclasts without exogenous stimulation. Immunology and Cell Biology 2008 86 5 453 459 2-s2.0-46749126610 10.1038/icb.2008.4 (Pubitemid 351948219)
41. Chenu C., Pfeilschifter J., Mundy G. R., Roodman G. D., Transforming growth factor β inhibits formation of osteoclast-like cells in long-term human marrow cultures. Proceedings of the National Academy of Sciences of the United States of America 1988 85 15 5683 5687 2-s2.0-1542792344
42. Hughes D. E., Dai A., Tiffee J. C., Li H. H., Munoy G. R., Boyce B. F., Estrogen promotes apoptosis of murine osteoclasts mediated by TGF- β Nature Medicine 1996 2 10 1132 1136 2-s2.0-0029798819 10.1038/nm1096-1132 (Pubitemid 26338639)
43. Roux S., Lambert-Comeau P., Saint-Pierre C., Lépine M., Sawan B., Parent J. L., Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis. Biochemical and Biophysical Research Communications 2005 333 1 42 50 2-s2.0-20444458264 10.1016/j.bbrc.2005.05.092 (Pubitemid 40813444)
44. Zimmerman G., Henle P., Kusswetter M., Moghaddam A., Wentzensen A., Richter W., Weiss S., Shyamsundar S., TGF- β 1 as a marker of delayed fracture healing. Bone 2006 38 3 456 457 2-s2.0-32844470613 10.1016/j.bone.2005. 08.026 (Pubitemid 43255441)