Addition of thiols to o-quinone methide: New 2-hydroxy-3- phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7)

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 48-53

  Sharma, Abhinay ^a   Santos, Isabela O ^b   Gaur, Pratibha ^a   Ferreira, Vitor F ^b   Garcia, Celia R S ^a   Da Rocha, David R ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

Antimalarial; Malaria; Naphthoquinone; Phenylsulfanylmethyl 1,4 naphthoquinone; Plasmodium falciparum

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 HYDROXY 3 [(2 TOLYLTHIO)METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [(3 TOLYLTHIO)METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [(4 TOLYLTHIO)METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [(NAPHTHALEN 2 YLTHIO)METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [(PHENYLTHIO)METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [(PROPYLTHIO)METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [[(4 CHLOROPHENYL)THIO]METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [[(4 FLUOROPHENYL)THIO]METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [[(4 HYDROXYPHENYL)THIO]METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [[(4 METHOXYPHENYL)THIO]METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [[(4 NITROPHENYL)THIO]METHYL]NAPHTHALENE 1,4 DIONE; 2 HYDROXY 3 [[[4 (METHYLTHIO)PHENYL]THIO]METHYL]NAPHTHALENE 1,4 DIONE; ANTIMALARIAL AGENT; DRUG; LAPACHOL; LAWSONE; QUINONE DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FLOW CYTOMETRY; HEMATOCRIT; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; KNOEVENAGEL CONDENSATION; MICROWAVE RADIATION; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; SERUM;

ANTIMALARIALS; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; INDOLEQUINONES; MALARIA, FALCIPARUM; MOLECULAR STRUCTURE; NAPHTHOQUINONES; PLASMODIUM FALCIPARUM; SULFHYDRYL COMPOUNDS;

EID: 84870184633     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.052     Document Type: Article

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