Molecular biologic approach to the diagnosis of pancreatic carcinoma using specimens obtained by EUS-guided fine needle aspiration

Gastroenterology Research and Practice

Volumn , Issue , 2012, Pages

  Kato, Kiyohito ^a   Kamada, Hideki ^a   Fujimori, Takayuki ^a   Aritomo, Yuuichi ^a   Ono, Masahiro ^a   Masaki, Tsutomu ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CA 19-9 ANTIGEN; CALCIUM BINDING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MICRORNA; MUCIN 1; MUCIN 2; MUCIN 5AC; MUCIN 6; PROTEIN P53; PROTEIN S100P; SMAD4 PROTEIN; UNCLASSIFIED DRUG;

CANCER DIAGNOSIS; CYTOLOGY; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; ENDOSCOPIC ECHOGRAPHY; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MOLECULAR DIAGNOSIS; NEEDLE BIOPSY; ONCOGENE K RAS; PANCREAS CARCINOMA; POINT MUTATION; REVIEW; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 84870174884     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2012/243524     Document Type: Review

References (47)

1. Hosoda W., Takagi T., Mizuno N., Shimizu Y., Sano T., Yamao K., Yatabe Y., Diagnostic approach to pancreatic tumors with the specimens of endoscopic ultrasound-guided fine needle aspiration. Pathology International 2010 60 5 358 364 2-s2.0-77951921587 10.1111/j.1440-1827.2010.02527.x
2. Yamao K., Sawaki A., Mizuno N., Shimizu Y., Yatabe Y., Koshikawa T., Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB): past, present, and future. Journal of Gastroenterology 2005 40 11 1013 1023 2-s2.0-30344482593 10.1007/s00535-005-1717-6 (Pubitemid 43055284)
3. Yoshinaga S., Suzuki H., Oda I., Saito Y., Role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for diagnosis of solid pancreatic masses. Digestive Endoscopy 2011 23 1 29 33 2-s2.0-79955584947 10.1111/j.1443-1661.2011.01112.x
4. Almoguera C., Shibata D., Forrester K., Martin J., Arnheim N., Perucho M., Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988 53 4 549 554 2-s2.0-0024292722
5. Collins M. A., Bednar F., Zhang Y., Brisset J. C., Galbán S., Galbán C. J., Rakshit S., Flannagan K. S., Adsay N. V., Pasca Di Magliano M., Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. Journal of Clinical Investigation 2012 122 2 639 653 2-s2.0-84863012865 10.1172/JCI59227
6. Tada M., Komatsu Y., Kawabe T., Sasahira N., Isayama H., Toda N., Shiratori Y., Omata M., Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: clinical utility for diagnosis of pancreatic tumor. American Journal of Gastroenterology 2002 97 9 2263 2270 2-s2.0-0036735913 10.1016/S0002- 9270(02)04337-X
7. Takahashi K., Yamao K., Okubo K., Sawaki A., Mizuno N., Ashida R., Koshikawa T., Ueyama Y., Kasugai K., Hase S., Kakumu S., Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA. Gastrointestinal Endoscopy 2005 61 1 76 79 2-s2.0-19944431069 10.1016/S0016-5107(04)02224-2 (Pubitemid 40169815)
8. Maluf-Filho F., Kumar A., Gerhardt R., Kubrusly M., Sakai P., Hondo F., Matuguma S. E., Artifon E., Monteiro Da Cunha J. E., César Machado M. C., Ishioka S., Forero E., Kras mutation analysis of fine needle aspirate under EUS guidance facilitates risk stratification of patients with pancreatic mass. Journal of Clinical Gastroenterology 2007 41 10 906 910 2-s2.0-37349114101 10.1097/MCG.0b013e31805905e9 (Pubitemid 350307077)
9. Wang X., Gao J., Ren Y., Gu J., Du Y., Chen J., Jin Z., Zhan X., Li Z., Huang H., Lv S., Gong Y., Detection of KRAS gene mutations in endoscopic ultrasound-guided fine-needle aspiration biopsy for improving pancreatic cancer diagnosis. American Journal of Gastroenterology 2011 106 12 2104 2111 2-s2.0-82955187335 10.1038/ajg.2011.281
10. Bournet B., Souque A., Senesse P., Assenat E., Barthet M., Lesavre N., Aubert A., O'Toole D., Hammel P., Levy P., Ruszniewski P., Bouisson M., Escourrou J., Cordelier P., Buscail L., Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis. Endoscopy 2009 41 6 552 557 2-s2.0-77953026609
11. Reicher S., Boyar F. Z., Albitar M., Sulcova V., Agersborg S., Nga V., Zhou Y., Li G., Venegas R., French S. W., Chung D. S., Stabile B. E., Eysselein V. E., Anguiano A., Fluorescence in situ hybridization and K-ras analyses improve diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses. Pancreas 2011 40 7 1057 1062 2-s2.0-79959462309 10.1097/MPA.0b013e3182200201
12. Hollstein M., Sidransky D., Vogelstein B., Harris C. C., p53 mutations in human cancers. Science 1991 253 5015 49 53 2-s2.0-0025894713 (Pubitemid 21917115)
13. Barton C. M., Staddon S. L., Hughes C. M., Hall P. A., O'Sullivan C., Kloppel G., Theis B., Russell R. C. G., Neoptolemos J., Williamson R. C. N., Lane D. P., Lemoine N. R., Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. British Journal of Cancer 1991 64 6 1076 1082 2-s2.0-0026334753
14. Slebos R. J. C., Hoppin J. A., Tolbert P. E., Holly E. A., Brock J. W., Zhang R. H., Bracci P. M., Foley J., Stockton P., McGregor L. M., Flake G. P., Taylor J. A., K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study. Cancer Epidemiology Biomarkers and Prevention 2000 9 11 1223 1232 2-s2.0-0033729483
15. Redston M. S., Caldas C., Seymour A. B., Hruban R. H., da Costa L., Yeo C. J., Kern S. E., p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Research 1994 54 11 3025 3033 2-s2.0-0028308492 (Pubitemid 24187791)
16. Itoi T., Takei K., Sofuni A., Itokawa F., Tsuchiya T., Kurihara T., Nakamura K., Moriyasu F., Tsuchida A., Kasuya K., Immunohistochemical analysis of p53 and MIB-1 in tissue specimens obtained from endoscopic ultrasonography-guided fine needle aspiration biopsy for the diagnosis of solid pancreatic masses. Oncology Reports 2005 13 2 229 234 2-s2.0-16244401478
17. Jahng A. W., Reicher S., Chung D., Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy. World Journal of Gastrointestinal Endoscopy 2010 2 11 362 368 10.4253/wjge.v2.i11.362
18. Caldas C., Hahn S. A., da Costa L. T., Redston M. S., Schutte M., Seymour A. B., Weinstein C. L., Hruban R. H., Yeo C. J., Kern S. E., Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature Genetics 1994 8 1 27 32 2-s2.0-0027969985 (Pubitemid 24274057)
19. Bartsch D., Shevlin D. W., Tung W. S., Kisker O., Wells S. A. Jr., Goodfellow P. J., Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas. Genes Chromosomes and Cancer 1995 14 3 189 195 2-s2.0-0028809606 10.1002/gcc.2870140306
20. Salek C., Benesova L., Zavoral M., Nosek V., Kasperova L., Ryska M., Strnad R., Traboulsi E., Minarik M., Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. World Journal of Gastroenterology 2007 13 27 3714 3720 2-s2.0-34547638469 (Pubitemid 47202169)
21. Maitra A., Hruban R. H., Pancreatic cancer. Annual Review of Pathology 2008 3 157 188 2-s2.0-41749100127 10.1146/annurev.pathmechdis.3.121806.154305 (Pubitemid 351488279)
22. Ringel J., Löhr M., The MUC gene family: their role in diagnosis and early detection of pancreatic cancer. Molecular Cancer 2003 2, article 9 2-s2.0-0345733557 10.1186/1476-4598-2-9 (Pubitemid 38751488)
23. Filipe M. I., Mucins and gastrointestinal malignancy. A new approach to the interpretation of biopsies. Acta Medica Portuguesa 1979 1 3 351 365 2-s2.0-0018669597 (Pubitemid 10238112)
24. Filipe M. I., Mucins in the human gastrointestinal epithelium: a review. Investigative and Cell Pathology 1979 2 3 195 216 2-s2.0-0018670460 (Pubitemid 10227906)
25. Giorgadze T. A., Peterman H., Baloch Z. W., Furth E. E., Pasha T., Shiina N., Zhang P. J., Gupta P. K., Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas: an immunohistochemical study with surgical pathology correlation. Cancer 2006 108 3 186 197 2-s2.0-33745210825 10.1002/cncr.21913
26. Wang Y., Gao J., Li Z., Jin Z., Gong Y., Man X., Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. International Journal of Cancer 2007 121 12 2716 2722 2-s2.0-36249004880 10.1002/ijc.22997 (Pubitemid 350136417)
27. Carrara S., Cangi M. G., Arcidiacono P. G., Perri F., Petrone M. C., Mezzi G., Boemo C., Talarico A., Cin E. D., Grassini G., Doglioni C., Testoni P. A., Mucin expression pattern in pancreatic diseases: findings from EUS-guided fine-needle aspiration biopsies. American Journal of Gastroenterology 2011 106 7 1359 1363 2-s2.0-79960072800 10.1038/ajg.2011.22
28. Dowen S. E., Crnogorac-Jurcevic T., Gangeswaran R., Hansen M., Eloranta J. J., Bhakta V., Brentnall T. A., Lüttges J., Klöppel G., Lemoine N. R., Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. American Journal of Pathology 2005 166 1 81 92 2-s2.0-19944385563 (Pubitemid 40051662)
29. Arumugam T., Logsdon C. D., S100P: a novel therapeutic target for cancer. Amino Acids 2011 41 4 893 899 2-s2.0-77952626963 10.1007/s00726-010-0496-4
30. Whiteman H. J., Weeks M. E., Dowen S. E., Barry S., Timms J. F., Lemoine N. R., Crnogorac-Jurcevic T., The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D. Cancer Research 2007 67 18 8633 8642 2-s2.0-34548795463 10.1158/0008-5472.CAN-07-0545 (Pubitemid 47437439)
31. Ohuchida K., Mizumoto K., Egami T., Yamaguchi H., Fujii K., Konomi H., Nagai E., Yamaguchi K., Tsuneyoshi M., Tanaka M., S100P is an early developmental marker of pancreatic carcinogenesis. Clinical Cancer Research 2006 12 18 5411 5416 2-s2.0-33749364644 10.1158/1078-0432.CCR-06-0298 (Pubitemid 44497255)
32. Arumugam T., Simeone D. M., van Golen K., Logsdon C. D., S100P promotes pancreatic cancer growth, survival, and invasion. Clinical Cancer Research 2005 11 15 5356 5364 2-s2.0-23044491967 10.1158/1078-0432.CCR-05-0092 (Pubitemid 41060808)
33. Crnogorac-Jurcevic T., Missiaglia E., Blaveri E., Gangeswaran R., Jones M., Terris B., Costello E., Neoptolemos J. P., Lemoine N. R., Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. Journal of Pathology 2003 201 1 63 74 2-s2.0-0141626696 10.1002/path.1418 (Pubitemid 37121204)
34. Kosarac O., Takei H., Zhai Q. J., Schwartz M. R., Mody D. R., S100P and XIAP expression in pancreatic ductal adenocarcinoma: potential novel biomarkers as a diagnostic adjunct to fine needle aspiration cytology. Acta Cytologica 2011 55 2 142 148 2-s2.0-79955663475 10.1159/000320913
35. Dim D. C., Jiang F., Qiu Q., Li T., Darwin P., Rodgers W. H., Peng H. Q., The usefulness of S100P, mesothelin,fascin, prostate stem cell antigen, and 14-3-3 sigma in diagnosing pancreatic adenocarcinoma in cytological specimens obtained by endoscopic ultrasound guided fine-needle aspiration. Diagnostic Cytopathology. In press 2-s2.0-79955152884 10.1002/dc.21684
36. Deng H., Shi J., Wilkerson M., Meschter S., Dupree W., Lin F., Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. American Journal of Clinical Pathology 2008 129 1 81 88 2-s2.0-38449086071 10.1309/5D76NDE81LE8G545 (Pubitemid 352038597)
37. Kato K., Gong J., Iwama H., Kitanaka A., Tani J., Miyoshi H., Nomura K., Mimura S., Kobayashi M., Aritomo Y., Kobara H., Mori H., Himoto T., Okano K., Suzuki Y., Murao K., Masaki T., The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo. Molecular Cancer Therapeutics 2012 11 3 549 560 2-s2.0-84859386824 10.1158/1535-7163.MCT-11-0594
38. Preis M., Gardner T. B., Gordon S. R., Pipas J. M., Mackenzie T. A., Klein E. E., Longnecker D. S., Gutmann E. J., Sempere L. F., Korc M., MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma. Clinical Cancer Research 2011 17 17 5812 5821 2-s2.0-82355164087 10.1158/1078-0432.CCR-11-0695
39. Jones S., Zhang X., Parsons D. W., Lin J. C. H., Leary R. J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., Hong S. M., Fu B., Lin M. T., Calhoun E. S., Kamiyama M., Walter K., Nikolskaya T., Nikolsky Y., Hartigan J., Smith D. R., Hidalgo M., Leach S. D., Klein A. P., Jaffee E. M., Goggins M., Maitra A., Iacobuzio-Donahue C., Eshleman J. R., Kern S. E., Hruban R. H., Karchin R., Papadopoulos N., Parmigiani G., Vogelstein B., Velculescu V. E., Kinzler K. W., Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008 321 5897 1801 1806 2-s2.0-52149123619 10.1126/science.1164368
40. Yamada M., Sekine S., Ogawa R., Taniguchi H., Kushima R., Tsuda H., Kanai Y., Frequent activating GNAS mutations in villous adenoma of the colorectum. Journal of Pathology 2012 228 1 113 118 2-s2.0-84864744918 10.1002/path.4012
41. Kanda M., Matthaei H., Wu J., Hong S. M., Yu J., Borges M., Hruban R. H., Maitra A., Kinzler K., Vogelstein B., Goggins M., Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology 2012 142 4 730.e9 733.e9 2-s2.0-84862777152 10.1053/j.gastro.2011.12.042
42. Schönleben F., Qiu W., Bruckman K. C., Ciau N. T., Li X., Lauerman M. H., Frucht H., Chabot J. A., Allendorf J. D., Remotti H. E., Su G. H., BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Letters 2007 249 2 242 248 2-s2.0-33947403142 10.1016/j.canlet.2006.09.007 (Pubitemid 46452934)
43. Henke A. C., Jensen C. S., Cohen M. B., Cytologic diagnosis of adenocarcinoma in biliary and pancreatic duct brushings. Advances in Anatomic Pathology 2002 9 5 301 308 2-s2.0-0036717832
44. David O., Green L., Reddy V., Kluskens L., Bitterman P., Attal H., Prinz R., Gattuso P., Pancreatic masses: a multi-institutional study of 364 fine-needle aspiration biopsies with histopathologic correlation. Diagnostic Cytopathology 1998 19 6 423 427 2-s2.0-0031790662 10.1002/(SICI)1097- 0339(199812)19:6423::AID-DC4>3.0.CO;2-N (Pubitemid 28536915)
45. Mori-Iwamoto S., Kuramitsu Y., Ryozawa S., Mikuria K., Fujimoto M., Maehara S. I., Maehara Y., Okita K., Nakamura K., Sakaida I., Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. International Journal of Oncology 2007 31 6 1345 1350 2-s2.0-38449118227
46. Itoi T., Sofuni A., Fukushima N., Itokawa F., Tsuchiya T., Kurihara T., Moriyasu F., Tsuchida A., Kasuya K., Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas. Journal of Gastroenterology 2007 42 5 389 394 2-s2.0-34447503264 10.1007/s00535-007-2017-0 (Pubitemid 47097256)
47. Ashida R., Nakata B., Shigekawa M., Mizuno N., Sawaki A., Hirakawa K., Arakawa T., Yamao K., Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancer. Journal of Experimental and Clinical Cancer Research 2009 28 1, article 83 2-s2.0-68149107766 10.1186/1756-9966-28-83