Model-based mapping of fat unsaturation and chain length by chemical shift imaging-phantom validation and in vivo feasibility

Magnetic Resonance in Medicine

Volumn 68, Issue 6, 2012, Pages 1815-1827

  Berglund, Johan ^a   Ahlström, Håkan ^a   Kullberg, Joel ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

chemical shift imaging; fat unsaturation; fatty acid composition; quantitative MRI; triglyceride mapping; water fat separation

Indexed keywords

CHAIN LENGTH; FATTY ACIDS; GAS CHROMATOGRAPHY; GAS OILS; LIQUID CHROMATOGRAPHY; MAGNETIC RESONANCE IMAGING; MAPPING; PHANTOMS;

CARBON-CHAIN LENGTH; CHEMICAL SHIFT IMAGING; FATTY ACID COMPOSITION; GAS-LIQUID CHROMATOGRAPHY; HIGH REPRODUCIBILITY; QUANTITATIVE DETERMINATIONS; QUANTITATIVE MRIS; SUBCUTANEOUS ADIPOSE TISSUES;

CHEMICAL SHIFT;

FATTY ACID; FATTY ACID CARBON CHAIN LENGTH; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; FATTY ACID DESATURATION; GAS LIQUID CHROMATOGRAPHY; IMAGE ANALYSIS; IMAGE QUALITY; IN VIVO STUDY; LIPID ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; VALIDATION PROCESS;

EID: 84870065463     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24196     Document Type: Article

References (48)

1. Ma J,. Dixon techniques for water and fat imaging. J Magn Reson Imaging 2008; 28: 543-558.
2. Buxton RB, Wismer GL, Brady TJ, Rosen BR,. Quantitative proton chemical-shift imaging. Magn Reson Med 1986; 3: 881-900.
3. Johnson LF, Shoolery JN,. Determination of unsaturation and average molecular weight of natural fats by nuclear magnetic resonance. Anal Chem 1962; 34: 1136-1139.
4. Field C, Angel A, Clandinin M,. Relationship of diet to the fatty acid composition of human adipose tissue structural and stored lipids. Am J Clin Nutr 1985; 42: 1206-1220.
5. van Staveren WA, Deurenberg P, Katan MB, Burema J, de Groot LC, Hoffmans MD,. Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. Am J Epidemiol 1986; 123: 455-463.
6. Risérus U, Willett WC, Hu FB,. Dietary fats and prevention of type 2 diabetes. Prog Lipid Res 2009; 48: 44-51.
7. Hu FB, Willett WC,. Optimal diets for prevention of coronary heart disease. JAMA 2002; 288: 2569-2578.
8. Yeung DKW, Griffith JF, Antonio GE, Lee FKH, Woo J, Leung PC,. Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging 2005; 22: 279-285.
9. Ren J, Dimitrov I, Sherry AD, Malloy CR,. Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. J Lipid Res 2008; 49: 2055-2062.
10. Strobel K, van den Hoff J, Pietzsch J,. Localized proton magnetic resonance spectroscopy of lipids in adipose tissue at high spatial resolution in mice in vivo. J Lipid Res 2008; 49: 473-480.
11. Lundbom J, Hakkarainen A, Fielding B, Söderlund S, Westerbacka J, Taskinen M-R, Lundbom N,. Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 Tesla: validation by gas chromatography. NMR Biomed 2010; 23: 466-472.
12. Lunati E, Farace P, Nicolato E, Righetti C, Marzola P, Sbarbati A, Osculati F,. Polyunsaturated fatty acids mapping by1H MR-chemical shift imaging. Magn Reson Med 2001; 46: 879-883.
13. Malcom G, Bhattacharyya A, Velez-Duran M, Guzman M, Oalmann M, Strong J,. Fatty acid composition of adipose tissue in humans: differences between subcutaneous sites. Am J Clin Nutr 1989; 50: 288-291.
14. Calder PC, Harvey DJ, Pond CM, Newsholme EA,. Site-specific differences in the fatty acid composition of human adipose tissue. Lipids 1992; 27: 716-720.
15. Hamilton G, Middleton MS, Yokoo T, Sirlin CB,. Regional Variability in Triglyceride Composition of Adipose Tissue Measured by 1H MRS. In: Proceedings of the 19th Annual Meeting of ISMRM, Montréal, Canada, 2011. p 3006.
16. Zancanaro C, Nano R, Marchioro C, Sbarbati A, Boicelli A, Osculati F,. Magnetic resonance spectroscopy investigations of brown adipose tissue and isolated brown adipocytes. J Lipid Res 1994; 35: 2191-2199.
17. Hamilton G, Smith DL, Bydder M, Nayak KS, Hu HH,. MR properties of brown and white adipose tissues. J Magn Reson Imaging 2011; 34: 468-473.
18. 1H-MRS Links Adipose Tissue Fat Composition to Liver Fat Content in Med with Metabolic Syndrome. In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden, 2010. p 4725.
19. Lundbom J, Hakkarainen A, Söderlund S, Westerbacka J, Lundbom N, Taskinen MR,. Visceral Fat Saturation is Positively Correlated with Liver Fat Content. In: Proceedings of the 19th Annual Meeting of ISMRM, Montréal, Canada, 2011. p 850.
20. Vlahov G,. Application of NMR to the study of olive oils. Prog Nucl Mag Res Spectrosc 1999; 35: 341-357.
21. Yu H, Shimakawa A, McKenzie CA, Brodsky E, Brittain JH, Reeder SB,. Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med 2008; 60: 1122-1134.
22. Hernando D, Kellman P, Haldar JP, Liang Z-P,. Robust water/fat separation in the presence of large field inhomogeneities using a graph cut algorithm. Magn Reson Med 2010; 63: 79-90.
23. Hamilton G, Yokoo T, Bydder M, Cruite I, Schroeder ME, Sirlin CB, Middleton MS,. In vivo characterization of the liver fat 1H MR spectrum. NMR Biomed 2011; 24: 784-790.
24. Liu C-Y, McKenzie CA, Yu H, Brittain JH, Reeder SB,. Fat quantification with IDEAL gradient echo imaging: correction of bias from T1 and noise. Magn Reson Med 2007; 58: 354-364.
25. Pineda AR, Reeder SB, Wen Z, Pelc NJ,. Cramér-Rao bounds for three-point decomposition of water and fat. Magn Reson Med 2005; 54: 625-635.
26. Hernando D, Haldar JP, Sutton BP, Ma J, Kellman P, Liang Z-P,. Joint estimation of water/fat images and field inhomogeneity map. Magn Reson Med 2008; 59: 571-580.
27. Berglund J, Kullberg J,. Three-dimensional water/fat separation and T 2 * estimation based on whole-image optimization-application in breathhold liver imaging at 1.5 T. Magn Reson Med. doi: 10.1002/mrm.23185.
28. Hindman JC,. Proton resonance shift of water in the gas and liquid states. J Chem Phys 1966; 44: 4582-4592.
29. Iggman D, Îrnlöv J, Vessby B, Cederholm T, Sjögren P, Risérus U,. Adipose tissue fatty acids and insulin sensitivity in elderly men. Diabetologia 2010; 53: 850-857.
30. Ackman RG, Sipos JC,. Application of specific response factors in the gas chromatographic analysis of methyl esters of fatty acids with flame ionization detectors. J Am Oil Chem Soc 1964; 41: 377-378.
31. Hudgins L, Hirsch J, Emken E,. Correlation of isomeric fatty acids in human adipose tissue with clinical risk factors for cardiovascular disease. Am J Clin Nutr 1991; 53: 474-482.
32. Peterson P, Brorson H, Månsson S,. Quantification of Fatty Acid Composition Using MR-Imaging and Spectroscopy at 3 T. In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden, 2010. p 2903.
33. Peterson P, Månsson S,. Simultaneous Quantification of Fat Fraction and Fatty Acid Composition Using MRI. In: Proceedings of the 19th Annual Meeting of ISMRM, Montréal, Canada, 2011. p 2712.
34. Bydder M, Girard O, Hamilton G,. Mapping the double bonds in triglycerides. Magn Reson Imaging 2011; 29: 1041-1046.
35. 1H-NMR spectroscopy. Eur J Lipid Sci Tech 2004; 106: 88-96.
36. Yeung DKW, Lam SL, Griffith JF, Chan ABW, Chen Z, Tsang PH, Leung PC,. Analysis of bone marrow fatty acid composition using high-resolution proton NMR spectroscopy. Chem Phys Lipids 2008; 151: 103-109.
37. Delikatny EJ, Chawla S, Leung D-J, Poptani H,. MR-visible lipids and the tumor microenvironment. NMR Biomed 2011; 24: 592-611.
38. 1H spectroscopy: validation in vivo. Am J Physiol Endocrinol Metab 1999; 276: E977-E989.
39. Angel A, Desai KS, Halperin ML,. Intracellular accumulation of free fatty acids in isolated white adipose cells. J Lipid Res 1971; 12: 104-111.
40. Chajès V, Lavillonnière F, Ferrari P, Jourdan M-L, Pinault M, Maillard V, Sébédio J-L, Bougnoux P,. Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of french patients. Cancer Epidemiol Biomarkers Prevent 2002; 11: 672-673.
41. Querleux B, Cornillon C, Jolivet O, Bittoun J,. Anatomy and physiology of subcutaneous adipose tissue by in vivo magnetic resonance imaging and spectroscopy: relationships with sex and presence of cellulite. Skin Res Technol 2002; 8: 118-124.
42. Brix G, Heiland S, Bellemann ME, Koch T, Lorenz WJ,. MR imaging of fat-containing tissues: Valuation of two quantitative imaging techniques in comparison with localized proton spectroscopy. Magn Reson Imaging 1993; 11: 977-991.
43. Yu H, Shimakawa A, Hines CDG, McKenzie CA, Hamilton G, Sirlin CB, Brittain JH, Reeder SB,. Combination of complex-based and magnitude-based multiecho water-fat separation for accurate quantification of fat-fraction. Magn Reson Med 2011; 66: 199-206.
44. Hernando D, Hines CD, Yu H, Reeder SB,. Addressing Phase Errors in Fat-Water Imaging Using a Mixed Magnitude/Complex Fitting Method. In: Proceedings of the 19th Annual Meeting of ISMRM, Montréal, Canada, 2011. p 753.
45. Sacchi R, Medina I, Aubourg SP, Addeo F, Paolillo L,. Proton nuclear magnetic resonance rapid and structure-specific determination of Iω-3 polyunsaturated fatty acids in fish lipids. J Am Oil Chem Soc 1993; 70: 225-228.
46. Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O,. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 1993; 29: 158-167.
47. Guillén MD, Ruiz A,. Edible oils: discrimination by 1H nuclear magnetic resonance. J Sci Food Agric 2003; 83: 338-346.
48. Bydder M, Yokoo T, Yu H, Carl M, Reeder SB, Sirlin CB,. Constraining the initial phase in water-fat separation. Magn Reson Imaging 2011; 29: 216-221.