Effects of quercetin supplementation on markers of muscle damage and inflammation after eccentric exercise

International Journal of Sport Nutrition and Exercise Metabolism

Volumn 22, Issue 6, 2012, Pages 430-437

  O'Fallon, Kevin S ^a   Kaushik, Diksha ^b   Michniak Kohn, Bozena ^b   Dunne, C Patrick ^c   Zambraski, Edward J ^d   Clarkson, Priscilla M ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c Food Protection Innovative Packaging Team   (United States)

^d U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

DOMS; Flavonoid; Muscle soreness; Strength loss

Indexed keywords

C REACTIVE PROTEIN; CREATINE KINASE; INTERLEUKIN 6; PLACEBO; QUERCETIN; ANTIOXIDANT; BIOLOGICAL MARKER; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ARM SWELLING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG EFFECT; ECCENTRIC MUSCLE CONTRACTION; ENZYME ACTIVITY; EXERCISE; FEMALE; HUMAN; MALE; MUSCLE INJURY; MUSCLE STRENGTH; MYOSITIS; NUTRITION; PROTEIN BLOOD LEVEL; ADOLESCENT; ADVERSE EFFECTS; ARM; BLOOD; DOUBLE BLIND PROCEDURE; EDEMA; FAST FOOD; FOOD; MYALGIA; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; ARM; BIOMARKERS; DOUBLE-BLIND METHOD; EDEMA; FEMALE; FOODS, SPECIALIZED; HUMANS; MALE; MUSCLE STRENGTH; MYALGIA; MYOSITIS; QUERCETIN; RESISTANCE TRAINING; SNACKS; SPORTS NUTRITIONAL PHYSIOLOGICAL PHENOMENA; YOUNG ADULT;

EID: 84870047703     PISSN: 1526484X     EISSN: 15432742     Source Type: Journal    
DOI: 10.1123/ijsnem.22.6.430     Document Type: Article

References (27)

1. Abbey, E.L., & Rankin, J.W. (2011). Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation. International Journal of Sport Nutrition and Exercise Metabolism, 21(2), 91-96. PubMed
2. Bryer, S.C., & Goldfarb, A.H. (2006). Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. International Journal of Sport Nutrition and Exercise Metabolism, 16, 270-280. PubMed (Pubitemid 43953298)
3. Chun, O.K., Chung, S.J., & Song, W.O. (2007). Estimated dietary flavonoid intake and major food sources of U.S. adults. The Journal of Nutrition, 137(5), 1244-1252. PubMed
4. Clarkson, P.M. (1992). Exercise-induced muscle damage - Animal and human models. Medicine and Science in Sports and Exercise, 24(5), 510-511. PubMed
5. Clarkson, P.M., & Hubal, M.J. (2002). Exercise-induced muscle damage in humans. American Journal of Physical Medicine & Rehabilitation, 81(11, Suppl) S52-S69. PubMed doi:10.1097/00002060-200211001-00007
6. Connolly, D.A., McHugh, M.P., Padilla-Zakour, O.I., Carlson, L., & Sayers, S.P. (2006). Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. British Journal of Sports Medicine, 40(8), 679-683. PubMed doi:10.1136/bjsm.2005.025429
7. Day, A.J., Bao, Y., Morgan, M.R., & Williamson, G. (2000). Conjugation position of quercetin glucuronides and effect on biological activity. Free Radical Biology &Medicine, 29(12), 1234-1243. PubMed doi:10.1016/S0891-5849(00)00416-0
8. Goldfarb, A.H., Bloomer, R.J., & McKenzie, M.J. (2005). Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise. Medicine and Science in Sports and Exercise, 37(2), 234-239. PubMed doi:10.1249/01.MSS.0000152887.87785.BE
9. Goldfarb, A.H., Garten, R.S., Cho, C., Chee, P.D., & Chambers, L.A. (2011). Effects of a fruit/berry/vegetable supplement on muscle function and oxidative stress. Medicine and Science in Sports and Exercise, 43(3), 501-508. PubMed doi:10.1249/MSS.0b013e3181f1ef48
10. Hirose, L., Nosaka, K., Newton, M., Laveder, A., Kano, M., Peake, J., & Suzuki, K. (2004). Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exercise Immunology Review, 10, 75-90. PubMed
11. Hong, Y.J., & Mitchell, A.E. (2006). Identification of glutathione-related quercetin metabolites in humans. Chemical Research in Toxicology, 19(11), 1525-1532. PubMed doi:10.1021/tx0601758
12. Kaushik, D., O'Fallon, K., Clarkson, P.M., & Michniak-Kohn, B. (2010). Absorption of total quercetin following oral administration of three quercetin formulations in human subjects. American Association of Pharmaceutical Scientists, M1102.
13. Kroon, P.A., Clifford, M.N., Crozier, A., Day, A.J., Donovan, J.L., Manach, C., & Williamson, G. (2004). How should we assess the effects of exposure to dietary polyphenols in vitro? The American Journal of Clinical Nutrition, 80(1), 15-21. PubMed (Pubitemid 41115549)
14. Miles, M.P., Andring, J.M., Pearson, S.D., Gordon, L.K., Kasper, C., Depner, C.M., & Kidd, J.R. (2008). Diurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variables. Journal of Applied Physiology, 104(2), 451-458. PubMed doi:10.1152/japplphysiol.00572.2007
15. Miles, M.P., Pearson, S.D., Andring, J.M., Kidd, J.R., & Volpe, S.L. (2007). Effect of carbohydrate intake during recovery from eccentric exercise on interleukin-6 and muscle-damage markers. International Journal of Sport Nutrition and Exercise Metabolism, 17(6), 507-520. PubMed
16. Nieman, D.C., Henson, D.A., Davis, J.M., Murphy, A.E., Jenkins, D.P., Gross, S.J., & Mayer, E.P. (2007). Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. Journal of Applied Physiology, 103(5), 1728-1735. PubMed doi:10.1152/japplphysiol.00707. 2007
17. Nieman, D.C., Henson, D.A., Gross, S.J., Jenkins, D.P., Davis, J.M., Murphy, E.A., & Mayer, E.P. (2007). Quercetin reduces illness but not immune perturbations after intensive exercise. Medicine and Science in Sports and Exercise, 39(9), 1561-1569. PubMed doi:10.1249/mss.0b013e318076b566
18. Nieman, D.C., Henson, D.A., Maxwell, K.R., Williams, A.S., McAnulty, S.R., Jin, F., & Lines, T.C. (2009). Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. Medicine and Science in Sports and Exercise, 41(7), 1467-1475. PubMed doi:10.1249/MSS.0b013e318199491f
19. Nosaka, K., & Clarkson, P.M. (1996). Changes in indicators of inflammation after eccentric exercise of the elbow flexors. Medicine and Science in Sports and Exercise, 28(8), 953-961. PubMed (Pubitemid 26275084)
20. O'Leary, K.A., Day, A.J., Needs, P.W., Mellon, F.A., O'Brien, N.M., & Williamson, G. (2003). Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: The role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochemical Pharmacology, 65(3), 479-491. PubMed doi:10.1016/ S0006-2952(02)01510-1
21. Overman, A., Chuang, C.C., & McIntosh, M. (2011). Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media. International Journal of Obesity, 35(9), 1165-1172. PubMed doi:10.1038/ijo.2010.272
22. Paulsen, G., Benestad, H.B., Strom-Gundersen, I., Morkrid, L., Lappegard, K.T., & Raastad, T. (2005). Delayed leukocytosis and cytokine response to high-force eccentric exercise. Medicine and Science in Sports and Exercise, 37(11), 1877-1883. PubMed doi:10.1249/01.mss.0000177064.65927.98
23. Peake, J.M., Suzuki, K., & Coombes, J.S. (2007). The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise. The Journal of Nutritional Biochemistry, 18(6), 357-371. PubMed doi:10.1016/j.jnutbio.2006.10.005
24. Phillips, T., Childs, A.C., Dreon, D.M., Phinney, S., & Leeuwenburgh, C. (2003). A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Medicine and Science in Sports and Exercise, 35(12), 2032-2037. PubMed doi:10.1249/01.MSS.0000099112.32342.10
25. Smith, C., Kruger, M.J., Smith, R.M., & Myburgh, K.H. (2008). The inflammatory response to skeletal muscle injury: Illuminating complexities. Sports Medicine (Auckland, N.Z.), 38(11), 947-969. PubMed doi:10.2165/00007256- 200838110-00005
26. Tidball, J.G., & Villalta, S.A. (2010). Regulatory interactions between muscle and the immune system during muscle regeneration. The American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 298(5), R1173-R1187.
27. Trombold, J.R., Barnes, J.N., Critchley, L., & Coyle, E.F. (2010). Ellagitannin consumption improves strength recovery 2-3 d after eccentric exercise. Medicine and Science in Sports and Exercise, 42(3), 493-498. PubMed doi:10.1249/MSS.0b013e3181b64edd