메뉴 건너뛰기




Volumn 17, Issue 1, 2013, Pages 27-45

Hepatitis C Virus Viral Assays in the Direct-Acting Antiviral Era

Author keywords

Genotype; Hepatitis C virus; Interleukin 28B; Limit of detection; Lower limit of quantification; Polymerase chain reaction; Resistance associated variants; Target not detected

Indexed keywords

ANTIVIRUS AGENT; BOCEPREVIR; INTERLEUKIN 28B; PEGINTERFERON; RIBAVIRIN; VIRUS RNA;

EID: 84870040222     PISSN: 10893261     EISSN: 15578224     Source Type: Journal    
DOI: 10.1016/j.cld.2012.09.002     Document Type: Review
Times cited : (6)

References (46)
  • 1
    • 77950648470 scopus 로고    scopus 로고
    • An overview about hepatitis C: a devastating virus
    • Bostan N., Mahmood T. An overview about hepatitis C: a devastating virus. Crit Rev Microbiol 2010, 36:91-133.
    • (2010) Crit Rev Microbiol , vol.36 , pp. 91-133
    • Bostan, N.1    Mahmood, T.2
  • 2
    • 75149163334 scopus 로고    scopus 로고
    • Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression
    • Davis G.L., Alter M.J., El-Serag H., et al. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 2010, 138:513-521.
    • (2010) Gastroenterology , vol.138 , pp. 513-521
    • Davis, G.L.1    Alter, M.J.2    El-Serag, H.3
  • 3
    • 80051676360 scopus 로고    scopus 로고
    • Epidemiology and outcome of hepatitis C relapse in transplant recipients
    • Angelico M. Epidemiology and outcome of hepatitis C relapse in transplant recipients. Transplant Proc 2011, 43:2457-2458.
    • (2011) Transplant Proc , vol.43 , pp. 2457-2458
    • Angelico, M.1
  • 4
    • 79958776380 scopus 로고    scopus 로고
    • Immune-mediated complications of the graft in interferon-treated hepatitis C positive liver transplant recipients
    • Selzner N., Guindi M., Renner E.L., et al. Immune-mediated complications of the graft in interferon-treated hepatitis C positive liver transplant recipients. J Hepatol 2011, 55:207-217.
    • (2011) J Hepatol , vol.55 , pp. 207-217
    • Selzner, N.1    Guindi, M.2    Renner, E.L.3
  • 5
    • 68249154875 scopus 로고    scopus 로고
    • Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
    • McHutchison J.G., Lawitz E.J., Shiffman M.L., et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med 2009, 361:580-593.
    • (2009) N Engl J Med , vol.361 , pp. 580-593
    • McHutchison, J.G.1    Lawitz, E.J.2    Shiffman, M.L.3
  • 6
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • Poordad F., McCone J., Bacon B.R., et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011, 364:1195-1206.
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.R.3
  • 7
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson I.M., McHutchison J.G., Dusheiko G., et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011, 364:2405-2416.
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 8
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon B.R., Gordon S.C., Lawitz E., et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011, 364:1207-1217.
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 9
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • Zeuzem S., Andreone P., Pol S., et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011, 364:2417-2428.
    • (2011) N Engl J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 12
    • 84855246805 scopus 로고    scopus 로고
    • Future treatment of chronic hepatitis C with direct acting antivirals: is resistance important?
    • Halfon P., Sarrazin C. Future treatment of chronic hepatitis C with direct acting antivirals: is resistance important?. Liver Int 2012, 32(Suppl 1):79-87.
    • (2012) Liver Int , vol.32 , Issue.SUPPL 1 , pp. 79-87
    • Halfon, P.1    Sarrazin, C.2
  • 13
    • 84871154340 scopus 로고    scopus 로고
    • HCV RNA viral load assessments in the era of direct acting antivirals
    • In press.
    • Cobb B, Pockros PJ, Vilchez RA, et al. HCV RNA viral load assessments in the era of direct acting antivirals. Am J Gastroenterol, in press.
    • Am J Gastroenterol
    • Cobb, B.1    Pockros, P.J.2    Vilchez, R.A.3
  • 14
  • 15
    • 84870018201 scopus 로고    scopus 로고
    • Recommendations for standardized nomenclature and definitions of viral response in trials of HCV investigational agents
    • Wedemeyer H., Jensen D.M., Godofsky E., et al. Recommendations for standardized nomenclature and definitions of viral response in trials of HCV investigational agents. Hepatology 2012, 10.1002/hep.25888.
    • (2012) Hepatology
    • Wedemeyer, H.1    Jensen, D.M.2    Godofsky, E.3
  • 16
    • 84859162561 scopus 로고    scopus 로고
    • Clinical relevance of detectable but not quantifiable hepatitis C virus RNA during boceprevir or telaprevir treatment
    • Harrington P.R., Zeng W., Naeger L.K. Clinical relevance of detectable but not quantifiable hepatitis C virus RNA during boceprevir or telaprevir treatment. Hepatology 2012, 55:1048-1057.
    • (2012) Hepatology , vol.55 , pp. 1048-1057
    • Harrington, P.R.1    Zeng, W.2    Naeger, L.K.3
  • 17
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial
    • Kwo P.Y., Lawitz E.J., McCone J., et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 2010, 376:705-716.
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3
  • 18
    • 79952172962 scopus 로고    scopus 로고
    • Overview of the PROVE studies evaluating the use of telaprevir in chronic hepatitis C genotype 1 patients
    • Burney T., Dusheiko G. Overview of the PROVE studies evaluating the use of telaprevir in chronic hepatitis C genotype 1 patients. Expert Rev Anti Infect Ther 2011, 9:151-160.
    • (2011) Expert Rev Anti Infect Ther , vol.9 , pp. 151-160
    • Burney, T.1    Dusheiko, G.2
  • 19
    • 34548481514 scopus 로고    scopus 로고
    • Prognostic significance of hepatitis C virus RNA detection by transcription-mediated amplification with negative polymerase chain reaction during therapy with peginterferon alpha and ribavirin
    • Kadam J.S., Gonzalez S.A., Ahmed F., et al. Prognostic significance of hepatitis C virus RNA detection by transcription-mediated amplification with negative polymerase chain reaction during therapy with peginterferon alpha and ribavirin. Dig Dis Sci 2007, 52:2525-2530.
    • (2007) Dig Dis Sci , vol.52 , pp. 2525-2530
    • Kadam, J.S.1    Gonzalez, S.A.2    Ahmed, F.3
  • 20
    • 56149095245 scopus 로고    scopus 로고
    • Interpretation of positive transcription-mediated amplification test results from polymerase chain reaction-negative samples obtained after treatment of chronic hepatitis C
    • Morishima C., Morgan T.R., Everhart J.E., et al. Interpretation of positive transcription-mediated amplification test results from polymerase chain reaction-negative samples obtained after treatment of chronic hepatitis C. Hepatology 2008, 48:1412-1419.
    • (2008) Hepatology , vol.48 , pp. 1412-1419
    • Morishima, C.1    Morgan, T.R.2    Everhart, J.E.3
  • 21
    • 84856756412 scopus 로고    scopus 로고
    • Clinical significance of discordant positive hepatitis C virus transcription-mediated amplification following end of treatment response
    • Thadani A., Harley J., Rubin J., et al. Clinical significance of discordant positive hepatitis C virus transcription-mediated amplification following end of treatment response. Dig Dis Sci 2012, 57:239-242.
    • (2012) Dig Dis Sci , vol.57 , pp. 239-242
    • Thadani, A.1    Harley, J.2    Rubin, J.3
  • 22
    • 84869996237 scopus 로고    scopus 로고
    • Abbott Real Time HCV PCR: PMA P100017 FDA summary of safety and effectiveness
    • Abbott Real Time HCV PCR: PMA P100017 FDA summary of safety and effectiveness. 2011.
    • (2011)
  • 25
    • 84871129050 scopus 로고    scopus 로고
    • New DAA FDA guidance
    • Available at: Accessed August
    • New DAA FDA guidance. Available at: Accessed August, 2012. http://www.natap.org/2012/HCV/041012_03.htm.
    • (2012)
  • 26
    • 84857634446 scopus 로고    scopus 로고
    • Resistance-associated variants in chronic hepatitis C patients treated with protease inhibitors
    • Gambarin-Gelwan M., Jacobson I.M. Resistance-associated variants in chronic hepatitis C patients treated with protease inhibitors. Curr Gastroenterol Rep 2012, 14:47-54.
    • (2012) Curr Gastroenterol Rep , vol.14 , pp. 47-54
    • Gambarin-Gelwan, M.1    Jacobson, I.M.2
  • 27
    • 82755182674 scopus 로고    scopus 로고
    • Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
    • Susser S., Vermehren J., Forestier N., et al. Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir. J Clin Virol 2011, 52:321-327.
    • (2011) J Clin Virol , vol.52 , pp. 321-327
    • Susser, S.1    Vermehren, J.2    Forestier, N.3
  • 28
    • 84864354805 scopus 로고    scopus 로고
    • Refinement of stopping rules during treatment of hepatitis C genotype 1 infection with boceprevir and peginterferon/ribavirin
    • Jacobson I.M., Marcellin P., Zeuzem S., et al. Refinement of stopping rules during treatment of hepatitis C genotype 1 infection with boceprevir and peginterferon/ribavirin. Hepatology 2012, 56:567-575.
    • (2012) Hepatology , vol.56 , pp. 567-575
    • Jacobson, I.M.1    Marcellin, P.2    Zeuzem, S.3
  • 29
    • 84871132860 scopus 로고    scopus 로고
    • Understanding futility rules in telaprevir combination treatment
    • In press.
    • Adda N, Bartels DJ, Gritz L, et al. Understanding futility rules in telaprevir combination treatment. Clin Gastroenterol Hepatol, in press.
    • Clin Gastroenterol Hepatol
    • Adda, N.1    Bartels, D.J.2    Gritz, L.3
  • 30
    • 84870018199 scopus 로고    scopus 로고
    • Characterization of telaprevir treatment outcomes and resistance in patients with prior treatment failure: results from the realize trial
    • Meyer S.D., Dierynck I., Ghys A., et al. Characterization of telaprevir treatment outcomes and resistance in patients with prior treatment failure: results from the realize trial. Hepatology 2012, 10.1002/hep.25962.
    • (2012) Hepatology
    • Meyer, S.D.1    Dierynck, I.2    Ghys, A.3
  • 31
    • 84864051750 scopus 로고    scopus 로고
    • Modeling quasispecies and drug resistance in hepatitis C patients treated with a protease inhibitor
    • Rong L., Ribeiro R.M., Perelson A.S. Modeling quasispecies and drug resistance in hepatitis C patients treated with a protease inhibitor. Bull Math Biol 2012, 74:1789-1817.
    • (2012) Bull Math Biol , vol.74 , pp. 1789-1817
    • Rong, L.1    Ribeiro, R.M.2    Perelson, A.S.3
  • 32
    • 80051810561 scopus 로고    scopus 로고
    • Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication
    • Delang L., Vliegen I., Froeyen M., et al. Comparative study of the genetic barriers and pathways towards resistance of selective inhibitors of hepatitis C virus replication. Antimicrob Agents Chemother 2011, 55:4103-4113.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4103-4113
    • Delang, L.1    Vliegen, I.2    Froeyen, M.3
  • 33
    • 79953733509 scopus 로고    scopus 로고
    • Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191)
    • Imhof I., Simmonds P. Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191). Hepatology 2011, 53:1090-1099.
    • (2011) Hepatology , vol.53 , pp. 1090-1099
    • Imhof, I.1    Simmonds, P.2
  • 34
    • 84871108809 scopus 로고    scopus 로고
    • GenoSure. Available at:
    • GenoSure. Available at: http://www.monogrambio.com/.
  • 35
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D., Fellay J., Thompson A.J., et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009, 461:399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 36
    • 84860290308 scopus 로고    scopus 로고
    • Genetic factors and hepatitis C virus infection
    • Thompson A.J. Genetic factors and hepatitis C virus infection. Gastroenterology 2012, 142:1335-1339.
    • (2012) Gastroenterology , vol.142 , pp. 1335-1339
    • Thompson, A.J.1
  • 37
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas D.L., Thio C.L., Martin M.P., et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009, 461:798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3
  • 38
    • 84858706070 scopus 로고    scopus 로고
    • Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load
    • Neukam K., Camacho A., Caruz A., et al. Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load. J Hepatol 2012, 56:788-794.
    • (2012) J Hepatol , vol.56 , pp. 788-794
    • Neukam, K.1    Camacho, A.2    Caruz, A.3
  • 39
    • 84864671668 scopus 로고    scopus 로고
    • Increased risk of severe hepatitis C virus recurrence after liver transplantation in patients with a T allele of IL28B rs12979860
    • Cisneros E., Banos I., Citores M.J., et al. Increased risk of severe hepatitis C virus recurrence after liver transplantation in patients with a T allele of IL28B rs12979860. Transplantation 2012, 94:275-280.
    • (2012) Transplantation , vol.94 , pp. 275-280
    • Cisneros, E.1    Banos, I.2    Citores, M.J.3
  • 40
    • 84864280702 scopus 로고    scopus 로고
    • The course of post-transplant hepatitis C infection: comparative impact of donor and recipient source of the favorable IL28B genotype and other variables
    • Duarte-Rojo A., Veldt B.J., Goldstein D.D., et al. The course of post-transplant hepatitis C infection: comparative impact of donor and recipient source of the favorable IL28B genotype and other variables. Transplantation 2012, 94:197-203.
    • (2012) Transplantation , vol.94 , pp. 197-203
    • Duarte-Rojo, A.1    Veldt, B.J.2    Goldstein, D.D.3
  • 41
    • 84858684409 scopus 로고    scopus 로고
    • Role of IL28B polymorphism in the development of hepatitis C virus-induced hepatocellular carcinoma, graft fibrosis, and post-transplant antiviral therapy
    • Eurich D., Boas-Knoop S., Bahra M., et al. Role of IL28B polymorphism in the development of hepatitis C virus-induced hepatocellular carcinoma, graft fibrosis, and post-transplant antiviral therapy. Transplantation 2012, 93:644-649.
    • (2012) Transplantation , vol.93 , pp. 644-649
    • Eurich, D.1    Boas-Knoop, S.2    Bahra, M.3
  • 42
    • 78049470128 scopus 로고    scopus 로고
    • Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C
    • Fukuhara T., Taketomi A., Motomura T., et al. Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C. Gastroenterology 2010, 139:1577-1585.
    • (2010) Gastroenterology , vol.139 , pp. 1577-1585
    • Fukuhara, T.1    Taketomi, A.2    Motomura, T.3
  • 43
    • 84865399454 scopus 로고    scopus 로고
    • IL28B SNP of donors and recipients can predict virological response to PEGIFN/RBV therapy in patients with recurrent hepatitis C after living donor liver transplantation
    • Kawaoka T., Takahashi S., Takaki S., et al. IL28B SNP of donors and recipients can predict virological response to PEGIFN/RBV therapy in patients with recurrent hepatitis C after living donor liver transplantation. J Gastroenterol Hepatol 2012, 27(9):1467-1472.
    • (2012) J Gastroenterol Hepatol , vol.27 , Issue.9 , pp. 1467-1472
    • Kawaoka, T.1    Takahashi, S.2    Takaki, S.3
  • 44
    • 79960452181 scopus 로고    scopus 로고
    • Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection
    • Lange C.M., Moradpour D., Doehring A., et al. Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection. J Hepatol 2011, 55:322-327.
    • (2011) J Hepatol , vol.55 , pp. 322-327
    • Lange, C.M.1    Moradpour, D.2    Doehring, A.3
  • 45
    • 79958792857 scopus 로고    scopus 로고
    • The impact of IL28B genetic variants on recurrent hepatitis C in liver transplantation: significant lessons from a dual graft case
    • Motomura T., Taketomi A., Fukuhara T., et al. The impact of IL28B genetic variants on recurrent hepatitis C in liver transplantation: significant lessons from a dual graft case. Am J Transplant 2011, 11:1325-1329.
    • (2011) Am J Transplant , vol.11 , pp. 1325-1329
    • Motomura, T.1    Taketomi, A.2    Fukuhara, T.3
  • 46
    • 79956284848 scopus 로고    scopus 로고
    • Realize trial final results: telaprevir-based regimen for genotype 1 hepatitis C virus infection in patients with prior null response, partial response or relapse to peginterferon/ribavirin
    • Ref type: abstract
    • Zeuzem S., Andreone P., Pol S., et al. Realize trial final results: telaprevir-based regimen for genotype 1 hepatitis C virus infection in patients with prior null response, partial response or relapse to peginterferon/ribavirin. J Hepatol 2011, 54:S3. Ref type: abstract.
    • (2011) J Hepatol , vol.54
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.